|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Visualisation of bladder cancer using 11C-choline PET: first clinical experience显示文摘 | Jong I J Pruim J Elsinga P | 2002 | Eur J Nucl Med2002，29，10： | 1 |
| 3 | Kinetics of the reaction between monomethylolurea and methylenediurea显示文摘 | de Jong J I de Jonge J | 1953 | Recueil des Travaux Chimiques des Pays-Bas et de la Belgique1953，72，： | 1 |
| 4 | Prognostic role of indoleamine 2,3-dioxygenase in endometrial carcinoma显示文摘 | DE JONG R A KEMA I P BOERMA A | 2012 | Gynecolc Oncol2012，126，3： | 1 |
| 5 | The higher classification of butterflies (Lepidoptera): problems and prospects显示文摘 | Jong R D Vane-Wright R I | 1996 | Entomologica Scandinavica1996，27，： | 1 |
| 6 | Ultrasound stratification of the FDG-avid thyroid nodule显示文摘 | Beech P Lavender I Jong I | 2016 | Clin Radiol2016，71，2： | 1 |
| 7 | ESAT-6 from Mycobacterium tuberculosis dissociates from its putative chaperone CFP-10 under acidic conditions and exhibits membrane-lysing activity 显示文摘 | DE JONGE M I PEHAU A G FRETZ M M | 2007 | J Bacteriol2007，189，16： | 1 |
| 8 | Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain显示文摘 | Farkas E De Jong G I Apró E | 2001 | Neurobiol Aging2001，22，2： | 1 |
| 9 | Determination of gas-oil miscibility conditions by interfacial tension measurements 显示文摘 | Rao Dandina N Lee Jong I | 2003 | Journal of Colloid and Interface Science2003，262，2： | 1 |
| 10 | Relation between bioavailability and fuel oil hydrocarbon composition in contaminated soils显示文摘 | De Jonge H Freijer J I Verstarten J M | 1997 | Environmental Science&Technology1997，31，3： | 1 |
| 11 | 查看详情显示文摘 | Janssen A H Schmidt I Jacobsen C J H Koster A J de Jong K P | | 0，，： | 1 |
| 12 | Correlates of physical activity in 2-year-old toddlers:the generation R study显示文摘 | Wijtzes A I Kooijman M N Kiefte-de Jong J C de Vries S I Henrichs J Jansen W | 2013 | Journal of pediatrics2013，163，3： | 1 |
| 13 | Arm motor controlas predictor for hypertonia after stroke : a prospective cohortstudy 显示文摘 | de Jong LD Hoonhorst MH Stuive I | 2011 | Arch Phys Med Rehabil2011，92，9： | 1 |
| 14 | 显示文摘 | Eun Kyoo Song Jong Keun Sean Min Cheol Kim Young-Jun Seol Seung Hun Lee Radiologic Measurement of Tibial Tuberosi- ty-Trochlear Groove ('I~F-TG) Dislance by Lower Extremity Rotational Profile Computed Tomogc'aphy in Koreans Clin Orlhop Surg | 2016 | Mar2016，8，1： | 1 |
| 15 | Axle Load Distribution Characterization for Mechanistic Pavement Design显示文摘 | Jong R Kim Leslie Titus-Glover Michael I Darter | 2007 | Journal of the Transportation Research Board2007，1629，： | 1 |
| 16 | Hierarchical test sequencing for complex systems显示文摘 | Boumen R Ruan S Jong I | 2009 | IEEE Trans on Systems Man and Cybernetics2009，39，3： | 1 |
| 17 | Identification of S-Genotypes by PCR-RFLP in breeding lines of Brassica显示文摘 | Jong I P | 2001 | Molecules and Cells2001，12，2： | 1 |
| 18 | Preparation and characterization of chitosan-based nanocomposite films with antimicrobial activity 显示文摘 | JONG W R SEOK I H HWAN M P | 2006 | Journal of Agricultural and Food Chemistry2006，54，16： | 1 |
| 19 | Electrochemical principles for active control of liquids on submillimeter scales显示文摘 | Gallardo B S Gupta V K Eagerton F D Jong L I Craig V S Shah R R Abbott N L | 1999 | Science1999，283，： | 1 |
| 20 | Carbohydrates and the dehydration inactivation of Lactobacillus plantarum: the role of moisture distribution and water activity显示文摘 | Linder L J M de Jong G I W Meerdink G | 1997 | J Food Engineering1997，31，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员