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739篇 您的检索式：作者名="JONG L"

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	题名	作者	年代	出处	被引量
1	Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease显示文摘AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) models.METHODS: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of GW.RESULTS: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.	Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang Hae Rim Kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon Kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun	2015	World Journal of Gastroenterology2015，21，45：	9
2	Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘	M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D’Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia	2008	Ultraschall in Med2008，，01：	4
3	Leitlinien für den Gebrauch von Ultraschallkontrastmitteln - Januar 2004显示文摘	T Albrecht M Blomley L Bolondi M Claudon J.-M Correas D Cosgrove L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani L Solbiati L Thorelius F Tranquart H Weskott T Whittingham	2004	Ultraschall in Med2004，，04：	3
4	Guidelines and Good Clinical Practice Recommendations for Contrast Enhanced Ultrasound (CEUS) - Update 2008显示文摘	M Claudon D Cosgrove T Albrecht L Bolondi M Bosio F Calliada J.-M Correas K Darge C Dietrich M D'Onofrio D Evans C Filice L Greiner K J?ger N Jong E Leen R Lencioni D Lindsell A Martegani S Meairs C Nols?e F Piscaglia P Ricci G Seidel B Skjoldbye L Solbia	2008	Ultraschall in Med2008，，01：	3
5	Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care:a randomised controlled trial 显示文摘	De Jonge E Schultz M J Spanjaard L	2003	Lancet2003，362，9389：	1
6	Evaluation of SOFA-based modelsfor predicting mortality in the ICU:A systematic review 显示文摘	Minne L Abu-Hanna A de Jonge E	2008	Crit Care2008，12，6：	1
7	Receptor-ligand binding assays: technologies and applications 显示文摘	JONG L A UGES D R FRANKE J P BISCHOFFR	2005	JChromatogr: B2005，829，12：	1
8	The relation between Acid Volatile Sulfides (AVS) and metal accumulation in aquatic invertebrates : implications of feeding behavior and ecology 显示文摘	De Jonge M Blust R Bervoets L	2010	Environmental Pollution2010，158，5：	1
9	Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial显示文摘	de Jonge E D Schultz M J Spanjaard L	2003	Lancet2003，362，9389：	1
10	Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women显示文摘	Schuit SC de Jong FH Stolk L	2005	Eur J Endocrinol2005，153，2：	1
11	Increased physical activity blunts the positive fat balance which occurs during the shift to a high fat diet 显示文摘	SMITH S JONGE L DE ZACHWIEJA J	1998	Int J Cbesity1998，22，3：	1
12	Study on macrophage ac- tivation and structural characteristics of purified polysaccharide from the liquid culture broth of Cordyceps militaris显示文摘	JONG S L JEONG S K DONG P W	2010	Carbohydrate Pol- ymers2010，，82：	1
13	The osteogenic effect of electrosprayed nanoscale collagen/ calcium phosphate coatings on titanium显示文摘	de Jonge L T Leeuwenburgh S C G van den Beucken J J J P	2010	Bioma?terials2010，31，9：	1
14	Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care; a randomised controlled trial显示文摘	De Jonge E Schultz M J Spanjaard L	2003	Lancet2003，362，9389：	1
15	Synthesis of supported palladium catalysts显示文摘	Toebes M L van Dillen J A de Jong K P	2001	Journal of Molecular Catalysis A: Chemical2001，173，1：	1
16	Colloids and colloid-facilitated transport of contaminants in soils 显示文摘	De Jonge L W Kjaegaard C Moldrup P	2004	Vadose Zone Journal2004，3，2：	1
17	UV-Vis microspectroscopy: Probing the initial stages of supported metal oxide catalyst preparation显示文摘	VAN DE WATER L G A BERGWERFF J A NIJHUIS T A DE JONG K P WECKHUYSEN B M	2005	J Am Chem Soc2005，127，14：	1
18	Isolation system for vibration control of stay cables显示文摘	Inho H Jong S L Jr Spencer B F	2009	Journal of Engineering Mechanics2009，135，1：	1
19	Peptide transport by the multidrug resistance protein MRP1 显示文摘	de Jong M C Slootstra J W Scheffer G L	2001	Cancer Res2001，61，6：	1
20	Caspase-3 activity as a prognostic factor in colorectal carcinoma显示文摘	Jonges L E Nagelkerke J F Ensink N G	2001	Lab Invest2001，81，5：	1

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