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| 1 | High level of preoperative carbohydrate antigen 19-9 is a poor survival predictor in gastric cancer显示文摘AIM:To assess the clinical significance and the prognostic value of preoperative serum carbohydrate antigen 19-9(CA 19-9)level in gastric cancer.METHODS:Between January 2005 and December2006,1960 patients underwent surgery for histologically confirmed gastric cancer.Of these,163 patients had elevated serum levels of CA 19-9 preoperatively,and1628 patients had normal serum levels of CA 19-9 preoperatively.For this study,325 patients were selected from the group of 1628 patients by age,sex,and cancer stage to serve as controls.Statistically significant differences in survival rates were calculated using the log-rank test.A P value less than 0.05 was considered statistically significant and was determined using SAS software.RESULTS:The baseline characteristics showed some differences between the two groups with regard to histology.Overall survival(OS)in the elevated and nonelevated group was 37.90 and 68.67 mo,respectively(P<0.001).N stage(P=0.001)was a significant predictor of disease-free survival by multivariate analysis.Also,N stage(P<0.001),and the presence of peritoneal metastasis(P<0.001)remained independent factors in predicting OS by multivariate analysis.Additionally,preoperative serum CA 19-9 levels were significantly associated with OS in univariate(P=0.009)and multivariate(P=0.021)analyses.CONCLUSION:Serum CA 19-9 can be considered an independent prognostic factor in predicting OS in patients anticipating surgery for gastric cancer. | A Ra Choi Jun Chul Park Jie-Hyun Kim Sung Kwan Shin Sang Kil Lee Yong Chan Lee Jae Bock Chung | 2013 | World Journal of Gastroenterology2013，19，32： | 8 |
| 2 | Long-term outcomes of autoimmune pancreatitis: a multicentre, international analysis显示文摘 | Phil A Hart Terumi Kamisawa William R Brugge Jae Bock Chung Emma L Culver László Czakó Luca Frulloni Vay Liang W Go Thomas M Gress Myung-Hwan Kim Shigeyuki Kawa Kyu Taek Lee Markus M Lerch Wei-Chih Liao Matthias L?hr Kazuichi Okazaki Ji Kon Ryu Nicolas Sc | 2013 | Gut2013，，12： | 2 |
| 3 | Simulation model for electron irradiated IGZO thin film transistors显示文摘An efficient drain current simulation model for the electron irradiation effect on the electrical parameters of amorphous In–Ga–Zn–O(IGZO) thin-film transistors is developed. The model is developed based on the specifications such as gate capacitance, channel length, channel width, flat band voltage etc. Electrical parameters of un-irradiated IGZO samples were simulated and compared with the experimental parameters and 1 kGy electron irradiated parameters. The effect of electron irradiation on the IGZO sample was analysed by developing a mathematical model. | G K Dayananda C Shantharama Rai A Jayarama Hyun Jae Kim | 2018 | Journal of Semiconductors2018，39，2： | 2 |
| 4 | Cancer-associated fibroblast-derived secreted phosphoprotein 1 contributes to resistance of hepatocellular carcinoma to sorafenib and lenvatinib显示文摘Background:Cancer-associated fibroblasts(CAFs)play an important role in the induction of chemo-resistance.This study aimed to clarify the mechanism underlying CAF-mediated resistance to two tyrosine kinase inhibitors(TKIs),sorafenib and lenvatinib,and to identify a novel therapeutic target for overcoming TKI resistance in hepatocellular carcinoma(HCC).Methods:We performed a systematic integrative analysis of publicly available gene expression datasets and whole-transcriptome sequencing data from 9 pairs of CAFs and para-cancer fibroblasts isolated from human HCC and para-tumor tissues,respectively,to identify key molecules that might induce resistance to TKIs.We then performed in vitro and in vivo experiments to validate selected targets and related mechanisms.The associations of plasma secreted phosphoprotein 1(SPP1)expression levels before sorafenib/lenvatinib treatment with progression-free survival(PFS)and overall survival(OS)of 54 patients with advanced HCC were evaluated using Kaplan-Meier and Cox regression analysis.Results:Bioinformatic analysis identified CAF-derived SPP1 as a candidate molecule driving TKI resistance.SPP1 inhibitors reversed CAF-induced TKI resistance in vitro and in vivo.CAF-derived SPP1 activated rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase(MAPK)and phosphatidylinositol 3-kinase(PI3K)/protein kinase B(AKT)/mammalian target of rapamycin(mTOR)through the integrin-protein kinase C-alpha(PKCα)signaling pathway and promoted epithelial-to-mesenchymal transition(EMT).A high plasma SPP1 level before TKI treatment was identified as an independent predictor of poor PFS(P=0.026)and OS(P=0.047)in patients with advanced HCC after TKI treatment.Conclusions:CAF-derived SPP1 enhances TKI resistance in HCC via bypass activation of oncogenic signals and EMT promotion.Its inhibition represents a promising therapeutic strategy against TKI resistance inHCC.Moreover,plasma SPP1 level before TKI treatment represents a potential biomarker for treatment response prediction. | JungWoo Eun Jung Hwan Yoon Hye Ri Ahn Seokhwi Kim Young Bae Kim Su Bin Lim Won Park TaeWook Kang Geum Ok Baek Moon Gyeong Yoon Ju A Son Ji HyangWeon Soon Sun Kim Hyo Jung Cho Jae Youn Cheong | 2023 | Cancer Communications2023，43，4： | 2 |
| 5 | Optimizing the aromatic yield and distribution from catalytic fast pyrolysis of biomass over ZSM-5显示文摘 | Foster A J Jae J Cheng Y T Huber G W Lobo R F | | 0，，： | 1 |
| 6 | Effect of seepage force on tunnel face stability显示文摘 | Nam S W Jae H A | 2003 | Canadian Geotechnical Journal2003，40，： | 1 |
| 7 | Evaluation of ordering stragies for constraint satisfaction reactive scheduling显示文摘 | Suh M S Lee A Lee Yung Jae | 1998 | Decision Support Systems1998，22，： | 1 |
| 8 | Optimizing the aromatic yield and distribution from catalytic fast pyrolysis of biomass over ZSM-5显示文摘 | FOSTER A J JAE J CHENG Y T HUBER G W LOBO R F | 2012 | Appl Catal A: Gen2012，，0： | 1 |
| 9 | Effect of liquidity on firms' R&D spending显示文摘 | Hao K Y Jae A B | 1993 | Economics of Innovation and New Technology1993，2，4： | 1 |
| 10 | miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression显示文摘 | Sang Yun Kim A Young Kim Hyun Woo Lee You Hwa Son Gha Young Lee Joo-Won Lee Yun Sok Lee Jae Bum Kim | 2010 | Biochemical and Biophysical Research Communications2010，，： | 1 |
| 11 | Transcatheter arterial em-bolization of nonvariceal upper gastrointestinal bleeding with n-butyl cyanoacrylate显示文摘 | Jae H J Chung J W Jung A Y | 2007 | Korean J Radiol2007，8，1： | 1 |
| 12 | The use of laparoscopic subtotal holecystectomy for complicated cholelithiasis 显示文摘 | Philips JAE Lawes DA Cook A J | 2008 | Surg Endosc2008，22，： | 1 |
| 13 | PPARγ signaling and metabolism: the good, the bad and the future 显示文摘 | Maryam A Jae MS Nasun H | 2013 | Nat Med2013，19，5： | 1 |
| 14 | A hybrid genetic algorithm and bacterial foraging approach for global optimization显示文摘 | Dong H K Ajith A Jae H C | 2007 | Information Sciences2007，177，2： | 1 |
| 15 | Depolymerization of lignoeelluloses biomass to fuel precursors: maximizing carbon efficiency by combining hydrolysis with pyrolysis显示文摘 | Jae J Tompsett G A Lin Y C | 2010 | Energy Environ Sci2010，3，3： | 1 |
| 16 | Impact of mixed convection on ceiling radiant cooling panel capacity显示文摘 | Jae Jeong W Mumma S A | 2003 | HVACScR Research2003，9，3： | 1 |
| 17 | A hybrid genetic aIgorithm and bacterial foraging approach for global optimization显示文摘 | Dong H K Ajith A Jae H C | 2007 | Information Sciences2007，，177： | 1 |
| 18 | Forecasting international tourist flows to Australia: a comparison between the direct and indirect methods显示文摘 | Jae H Kima tmad A Moosab | 2005 | Tourism Management2005，，5： | 1 |
| 19 | Asthma, chronic obstructive pulmonary disease, and type 2 diabetes in the Women's Health Study 显示文摘 | Song Y Klevak A Manson JAE | 2010 | Diabetes research and clinical practice2010，90，3： | 1 |
| 20 | A PPAR',/- FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis 显示文摘 | JOHAN W J JAE M S ANNETTE R A | 2012 | Nature2012，485，7398： | 1 |
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