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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | Exploring in vitro roles of siRNA in cardiovascular disease显示文摘RNA 干扰( RNAi )是通过 搁浅whichdouble 的 RNA 沉默的适应防卫机制在顺序特定的 manner.It 的血缘的基因被采用了在功能的 genomics 的一个强大的工具学习的 widelyas ,目标确认并且治疗学 productdevelopment.Similarly ,到涉及心血管的疾病的 引起thedisease 基因的 silencing 的小介入的 RNA ( siRNA )的申请使大 progress.In 成为了 thisoverview 。 | Yu TANG Yu-zhi GE James Q YIN | 2007 | Acta Pharmacologica Sinica2007，28，1： | 3 |
| 3 | Laparoscopic resection of gastrointestinal stromal tumors:Does laparoscopic surgery provide an adequate oncologic resection?显示文摘Gastrointestinal stromal tumors (GISTs) are rare tumors of the GI tract.Surgical resection remains the mainstay of non-metastatic disease.However,the ability to provide an adequate oncologic resection using laparoscopic surgery is still an area of debate.This is a thorough review of the current literature,looking particularly at the use of laparoscopic surgery for larger GISTs and the long-term oncologic outcomes compared to the results of open surgery.Laparoscopic resections provide an adequate oncologic result for GISTs of all sizes,including those greater than 5 cm in size. | Joseph J Kim James Y Lim Scott Q Nguyen | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，9： | 3 |
| 4 | ON FORMATION OF TIDAL FRONTS IN COASTAL SEAS显示文摘An energy equation which includes the effects of potential energy,turbu-lent dissipation,heat flux and density flux due to fresh water discharge from estuaries isderived to evaluate the formation of frontal structures in coastal seas.Two different formsof tidal mixing criteria emerge which are the h/u^3 of Simoson and Hunter(1974)for openshallow water and the h/u of Nunes et al(1989)for estuaries.The theory is capable of predictiong tidal fronts in areas where both surface and lateral input of buoyancy are signifi-cant.The theory is applied to a tidal estuary and the locations of haline fronts which resultfrom the influence of the fresh water discharge are predicted.The effect of surface heatingon the formation and location of the frontal system is also discussed for the estuary. | Wang Xiao-huaDepartment of Geography and Oceanography, University College, Australian Defence ForceAcademy, Canberra ACT 2600, Australia, Email :h-wang @ adfa.oz. auM. L. HeronPhysics Department, James Cook University Townsville, Q 4811, AustraliaChen WeiThe Second Institute of Oceanography, State Oceanic Administration, Hangzhou 310012,P. R. China | 1998 | Journal of Hydrodynamics1998，10，3： | 2 |
| 5 | Thermal blooming of repetitively pulsed laser beams显示文摘 | JAMES W JULIUS Q L | 1974 | Journal of the Optical Society of America1974，64，： | 1 |
| 6 | Cardi- ovascular effects of strenuous exercise in adult recreational hockey: the hockey heart study显示文摘 | MELISSA S F LAURIE Q JAMES H RIMMER | 2002 | CMAJ2002，166，3： | 1 |
| 7 | Silencing of hdm2 oncogene by siRNA inhibits p53-dependent human breast cancer显示文摘 | Tie-gang Liu James Q Yin Bo-yang Shang | 2005 | Cancer Gene Therapy November2005，11，11： | 1 |
| 8 | On positive realness of descriptor system显示文摘 | James Lam Xu S Y | 2000 | IEEE Trans on Circuits and Systems-I: Fundamental Theory and Applications2000，49，3： | 1 |
| 9 | Contact Behavior of Spherical Elastic Particles: a Computational Study of Particle Adhesion and Deformations 显示文摘 | James Q F | 2000 | Colloid and Surfaces(A)2000，172，3： | 1 |
| 10 | Cutting Tempera- tures in Hard Turning Chromium Hardfacings with PCBN Tooling显示文摘 | REN X J YANG Q X JAMES R D | 2004 | Journal of Materials Processing Technology2004，147，11： | 1 |
| 11 | Optimal model reduction of discrete-time descriptor systems显示文摘 | James L Zhang Q L | 2001 | Int Journal of System Sci2001，32，5： | 1 |
| 12 | Models for water and power scheduling for the California state water project显示文摘 | Hossein M S James Q C | 1986 | Water Resources Bulletin1986，22，4： | 1 |
| 13 | Uteroplacental insufficiency affects epigenetie determinants of chrematin structure in brains of neonatal and juvenile IUGR rats显示文摘 | Ke X Lei Q James SJ | 2006 | Physiol Genomics2006，25，1： | 1 |
| 14 | Robust D-stability analysis for uncertain discrete singular systems with state delay显示文摘 | XU S Y JAMES LAM ZHANG L Q | 2002 | IEEE Trans on Circuits and Systems-Ⅰ:Fundamental Theory and Applications2002，49，4： | 1 |
| 15 | Wind load on cylinder with spanwise protrusion 显示文摘 | James D F Truong Q S | 1972 | Journal of the Engineering Mechanics Division ASCE1972，98，： | 1 |
| 16 | Purification and immunecharacterization of human brain glutamine synthetase and its detection in cerebrospinal fluid and scram by a sandwich enzyme immunoassay 显示文摘 | HAYRETHN T GUO Q JAMES B | 1995 | Journal of Immunological Methods1995，188，1： | 1 |
| 17 | Effect of applied hydro- static stress on the hydrationof portland cement and c3s显示文摘 | Zhou Q Beaudoin James J | 2003 | Advances in Cment Research2003，15，1： | 1 |
| 18 | On Positive Realness of Descriptor System 显示文摘 | Zhang L Q James Lam and Xu S Y | 2000 | IEEE Transaction on circuits and systems - Ⅰ: Fundamental Theory and applications2000，49，3： | 1 |
| 19 | Accuracy of drug infusion pump under computer control显示文摘 | STEPHEN B C TIMOTHY J Q JAMES R J | 1992 | IEEE Transactions on Biomedical Engineering1992，39，9： | 1 |
| 20 | Odd - skipped related is required for development of the metanephric kindney and regulates formation and differentiation of kidney precursor cells 显示文摘 | James RG Kamei CN Wang Q | 2006 | Development2006，133，15： | 1 |
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