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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 1: Definitions and diagnosis显示文摘 | Axel Dignass Rami Eliakim Fernando Magro Christian Maaser Yehuda Chowers Karel Geboes Gerassimos Mantzaris Walter Reinisch Jean-Frederic Colombel Severine Vermeire Simon Travis James O. Lindsay Gert Van Assche | 2012 | Journal of Crohn’s and Colitis2012，，10： | 12 |
| 3 | Laparoscopic Colectomy for Cancer Is Not Inferior to Open Surgery Based on 5-Year Data From the COST Study Group Trial显示文摘 | James Fleshman Daniel J. Sargent Erin Green Mehran Anvari Steven J. Stryker Robert W. Beart Michael Hellinger Richard Flanagan Walter Peters Heidi Nelson | 2007 | Annals of Surgery2007，，4： | 7 |
| 4 | The effect of surface roughness on claw and adhesive hair performance in the dock beetle Gastrophysa viridula显示文摘自然粘合剂系统被改编属于不平的表面,而是内在的机制充分没被澄清。为甲壳虫 Gastrophysa viridula 的附件力量用一台离心机设备与不同粗糙在表面的环氧基树脂演员组上被记录。复制品用擦亮纸标准化,粗糙尺寸从 0.05 ~ 30 m 并且船坞叶子(Rumex obtusifolius )做的。甲壳虫在光滑的底层上或在他们的主人植物的叶子的演员组上与多达 36 次身体重量的一个安全因素粘住。在不平的底层上,力量在小规模粗糙是更低的大部分和最小(0.05 m 粗糙尺寸,与 5 的一个吝啬的安全因素) 被观察。爪的移动与粗糙尺寸为不平的底层在力量导致了重要减小 12 m。毛乎乎的粘合剂系统本身的附件力量(没有爪) 稍微增加了从对大规模表面粗糙小规模,但是在在光滑的底层上看见的水平下面留下了。这被 setal 尖端的无能解释做完整的接触到表面。 | James M. R. Bullock Walter Federle | 2011 | Insect Science2011，18，3： | 6 |
| 5 | Second European evidence-based consensus on the diagnosis and management of ulcerative colitis Part 2: Current management显示文摘 | Axel Dignass James O. Lindsay Andreas Sturm Alastair Windsor Jean-Frederic Colombel Mathieu Allez Gert D’Haens André D’Hoore Gerassimos Mantzaris Gottfried Novacek Tom ?resland Walter Reinisch Miquel Sans Eduard Stange Severine Vermeire Simon Travis Gert | 2012 | Journal of Crohn’s and Colitis2012，，10： | 4 |
| 6 | A Prospective Study of Long-term Intake of Dietary Fiber and Risk of Crohn’s Disease and Ulcerative Colitis显示文摘 | Ashwin N. Ananthakrishnan Hamed Khalili Gauree G. Konijeti Leslie M. Higuchi Punyanganie de Silva Joshua R. Korzenik Charles S. Fuchs Walter C. Willett James M. Richter Andrew T. Chan | 2013 | Gastroenterology2013，，： | 3 |
| 7 | Secular Trends in Incidence of Atrial Fibrillation in Olmsted County, Minnesota, 1980 to 2000, and Implications on the Projections for Future Prevalence显示文摘 | Yoko Miyasaka Marion E. Barnes Bernard J. Gersh Stephen S. Cha Kent R. Bailey Walter P. Abhayaratna James B. Seward Teresa S.M. Tsang | 2006 | Circulation2006，，2： | 2 |
| 8 | Management and Outcome of Permanent Pacemaker and Implantable Cardioverter-Defibrillator Infections显示文摘 | Muhammad R. Sohail Daniel Z. Uslan Akbar H. Khan Paul A. Friedman David L. Hayes Walter R. Wilson James M. Steckelberg Sarah Stoner Larry M. Baddour | 2007 | Journal of the American College of Cardiology2007，，18： | 2 |
| 9 | Effect of Graphene Nanoribbons (TexasPEG) on locomotor function recovery in a rat model of lumbar spinal cord transection显示文摘A sharply transected spinal cord has been shown to be fused under the accelerating influence of membrane fusogens such as polyethylene glycol(PEG)(GEMINI protocol). Previous work provided evidence that this is in fact possible. Other fusogens might improve current results. In this study, we aimed to assess the effects of PEGylated graphene nanoribons(PEG-GNR, and called 'Texas PEG' when prepared as 1 wt% dispersion in PEG600) versus placebo(saline) on locomotor function recovery and cellular level in a rat model of spinal cord transection at lumbar segment 1(L_1) level. In vivo and in vitro experiments(n = 10 per experiment) were designed. In the in vivo experiment, all rats were submitted to full spinal cord transection at L_1 level. Five weeks later, behavioral assessment was performed using the Basso Beattie Bresnahan(BBB) locomotor rating scale. Immunohistochemical staining with neuron marker neurofilament 200(NF200) antibody and astrocytic scar marker glial fibrillary acidic protein(GFAP) was also performed in the injured spinal cord. In the in vitro experiment, the effects of Texas PEG application for 72 hours on the neurite outgrowth of SH-SY5 Y cells were observed under the inverted microscope. Results of both in vivo and in vitro experiments suggest that Texas PEG reduces the formation of glial scars, promotes the regeneration of neurites, and thereby contributes to the recovery of locomotor function of a rat model of spinal cord transfection. | C-Yoon Kim William K. A. Sikkema Jin Kim Jeong Ah Kim James Walter Raymond Dieter Hyung-Min Chung Andrea Mana James M. Tour Sergio Canavero | 2018 | Neural Regeneration Research2018，13，8： | 2 |
| 10 | The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships显示文摘 | Walter W. Powell Kenneth W. Koput James I. Bowie Laurel Smith-Doerr | 2002 | Regional Studies2002，，3： | 2 |
| 11 | Factors that influence induction of gastroesophageal reflux in normal human subjects显示文摘 | John Dent MD Wylie J. Dodds MD Walter J. Hogan MD James Toouli MD | 1988 | Digestive Diseases and Sciences1988，，3： | 2 |
| 12 | Relationships of leaf dark respiration to leaf nitrogen, specific leaf area and leaf life-span: a test across biomes and functional groups显示文摘 | Peter B. Reich Michael B. Walters David S. Ellsworth James M. Vose John C. Volin Charles Gresham William D. Bowman | 1998 | Oecologia1998，，4： | 2 |
| 13 | Naming and outline of Dothideomycetes-2014 including proposals for the protection or suppression of generic names显示文摘Article 59.1,of the International Code of Nomenclature for Algae,Fungi,and Plants(ICN;Melbourne Code),which addresses the nomenclature of pleomorphic fungi,became effective from 30 July 2011.Since that date,each fungal species can have one nomenclaturally correct name in a particular classification.All other previously used names for this species will be considered as synonyms.The older generic epithet takes priority over the younger name.Any widely used younger names proposed for use,must comply with Art.57.2 and their usage should be approved by the Nomenclature Committee for Fungi(NCF).In this paper,we list all genera currently accepted by us in Dothideomycetes(belonging to 23 orders and 110 families),including pleomorphic and nonpleomorphic genera.In the case of pleomorphic genera,we follow the rulings of the current ICN and propose single generic names for future usage.The taxonomic placements of 1261 genera are listed as an outline.Protected names and suppressed names for 34 pleomorphic genera are listed separately.Notes and justifications are provided for possible proposed names after the list of genera.Notes are also provided on recent advances in our understanding of asexual and sexual morph linkages in Dothideomycetes.A phylogenetic tree based on four gene analyses supported 23 orders and 75 families,while 35 families still lack molecular data. | Nalin N.Wijayawardene Pedro W.Crous Paul M.Kirk David L.Hawksworth Saranyaphat Boonmee Uwe Braun Dong-Qin Dai Melvina J.D’souza Paul Diederich Asha Dissanayake Mingkhuan Doilom Singang Hongsanan E.B.Gareth Jones Johannes Z.Groenewald Ruvishika Jayawardena James D.Lawrey Jian-Kui Liu Robert Lücking Hugo Madrid Dimuthu S.Manamgoda Lucia Muggia Matthew P.Nelsen Rungtiwa Phookamsak Satinee Suetrong Kazuaki Tanaka Kasun M.Thambugala Dhanushka N.Wanasinghe Saowanee Wikee Ying Zhang Andre Aptroot H.A.Ariyawansa Ali H.Bahkali D.Jayarama Bhat Cécile Gueidan Putarak Chomnunti G.Sybren De Hoog Kerry Knudsen Wen-Jing Li Eric H.C.McKenzie Andrew N.Miller Alan J.L.Phillips Marcin Piatek Huzefa A.Raja Roger S.Shivas Bernad Slippers Joanne E.Taylor Qing Tian Yong Wang Joyce H.C.Woudenberg Lei Cai Walter M.Jaklitsch Kevin D.Hyde | 2014 | Fungal Diversity2014，，6： | 2 |
| 14 | Comparative genomics of major histocompatibility complexes显示文摘 | James Kelley Lutz Walter John Trowsdale | 2005 | Immunogenetics2005，，10： | 1 |
| 15 | Estimation of net physical transport and hydraulic residence times for a coastal plain estuary using box models显示文摘 | James D. Hagy Walter R. Boynton Lawrence P. Sanford | 2000 | Estuaries2000，，3： | 1 |
| 16 | How do radiographic techniques affect image quality and patient doses in CT?显示文摘 | Walter Huda James G Ravenel Ernest M Scalzetti | 2002 | Seminars in Ultrasound CT and MRI2002，，5： | 1 |
| 17 | Arsenic: Extension of its endocrine disruption potential to interference with estrogen receptor-mediated signa- ling 显示文摘 | Walter HW James DY | 2007 | Toxicological Sciences2007，98，1： | 1 |
| 18 | The phenylala- nine ammonia lyase (PAL) gene family shows a gymno- sperm - specific lineage 显示文摘 | Ujwal R B James H L W Walter L | 2012 | BMC Genomics2012，13，3： | 1 |
| 19 | MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy显示文摘 | Christine U. Lee James F. Glockner Kevin J. Glaser Meng Yin Jun Chen Akira Kawashima Bohyun Kim Walter K. Kremers Richard L. Ehman James M. Gloor | 2012 | Academic Radiology2012，，7： | 1 |
| 20 | Additive Models for Multitrait-Muhimethod Data With a Multiplicative Trait-Meth- od Relationship: A Simulation Study显示文摘 | ZHANG L D JIN R WALTER L L JAMES A | 2014 | Structural Equation Model- ing: A Muhidisciplinary Journal2014，，21： | 1 |
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