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| 1 | 中国及其他分布区域野生虎的系统地理学和遗传起源研究进展显示文摘世界野生虎(Pantheratigris)传统上被划分为8个亚种,其中3个亚种已于20世纪灭绝,而剩余种群的生存仍然受到偷猎、栖息地丧失和片断化的威胁。作为唯一栖息着4个现存虎亚种的国家,中国在世界虎的保护事业中负有重要责任,然而其野生和圈养虎的分类地位却仍然不确定。最近一项研究(Luoetal,2004)从所有现存野生虎分布地区(包括中国)采集了134份“基准样品”(即原产野外或有确定地域起源的个体生物样品),对虎的系统地理学、种群结构以及遗传起源进行了全面分析。所用的分子标记包括四千碱基对的线粒体DNA、30个核基因组微卫星位点,以及MHC-DRB基因。研究结果表明,虽然虎的整体遗传多态性较低,但是种群分化程度很高,它们被划分为6个,而不是5个现存亚种(1)西伯利亚虎(P.t.altaica);(2)苏门答腊虎(P.t.sumatrae);(3)孟加拉虎(P.t.tigris);(4)华南虎(P.t.amoyensis);(5)印支虎(P.t.corbetti);(6)新定义的亚种马来虎,暂命名为P.t.Jacksoni。由于所研究样本量有限,目前暂定的华南虎亚种还需进一步确定。现有华南虎圈养种群包括遗传关系相距较远的两支一支与印支虎(P.t.corbetti)无异;而另一支则与其他种群均相距甚远,可能代表了真正的华南虎(P.t.amoyensis)。利用分子生物学方法对中国动物园中圈养虎的遗传起源调查亟待进行,以确认该圈养种群整体的遗传独特性或者非独特性。换言之,这将是确认华南虎是否仍然存在的关键。 | 罗述金 Jae-heup Kim Warren E.Johnson Dale G.Miquelle 黄世强 潘文石 James L.D.Smith Stephen J.O'Brien | 2006 | Zoological Research2006，27，4： | 10 |
| 2 | Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention显示文摘 | Ruchira Glaser Faith Selzer David P. Faxon Warren K. Laskey Howard A. Cohen James Slater Katherine M. Detre Robert L. Wilensky | 2005 | Circulation2005，，2： | 4 |
| 3 | Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA显示文摘 | Luigi Warren Philip D. Manos Tim Ahfeldt Yuin-Han Loh Hu Li Frank Lau Wataru Ebina Pankaj K. Mandal Zachary D. Smith Alexander Meissner George Q. Daley Andrew S. Brack James J. Collins Chad Cowan Thorsten M. Schlaeger Derrick J. Rossi | 2010 | Cell Stem Cell2010，，5： | 4 |
| 4 | New players in the regulation of ecdysone biosynthesis显示文摘Insect ecdysone steroid hormone regulates major developmental transitions, such as molting and metamorphosis. The production of ecdysone correlates well with the timing of these transitions. Finding out how the ecdysone biosynthesis is regulated is crucial to fully understand these sophisticated developmental switches. Here we summarized recent findings in the regulation of ecdysone biosynthesis from the aspects of cell signaling, key biosynthetic enzymes and substrate cholesterol trafficking. | Xun Huang James T. Warren Lawrence I. Gilbert | 2008 | Journal of Genetics and Genomics2008，35，1： | 3 |
| 5 | Towards a standard diet-induced and biopsy-confirmed mouse model of non-alcoholic steatohepatitis: Impact of dietary fat source显示文摘BACKGROUND The trans-fat containing AMLN(amylin liver non-alcoholic steatohepatitis,NASH)diet has been extensively validated in C57BL/6J mice with or without the Lep^ob/Lep^ob(ob/ob)mutation in the leptin gene for reliably inducing metabolic and liver histopathological changes recapitulating hallmarks of NASH.Due to a recent ban on trans-fats as food additive,there is a marked need for developing a new diet capable of promoting a compatible level of disease in ob/ob and C57BL/6J mice.AIM To develop a biopsy-confirmed mouse model of NASH based on an obesogenic diet with trans-fat substituted by saturated fat.METHODS Male ob/ob mice were fed AMLN diet or a modified AMLN diet with trans-fat(Primex shortening)substituted by equivalent amounts of palm oil[Gubra amylin NASH,(GAN)diet]for 8,12 and 16 wk.C57BL/6J mice were fed the same diets for 28 wk.AMLN and GAN diets had similar caloric content(40%fat kcal),fructose(22%)and cholesterol(2%)level.RESULTS The GAN diet was more obesogenic compared to the AMLN diet and impaired glucose tolerance.Biopsy-confirmed steatosis,lobular inflammation,hepatocyte ballooning,fibrotic liver lesions and hepatic transcriptome changes were similar in ob/ob mice fed the GAN or AMLN diet.C57BL/6J mice developed a mild to moderate fibrotic NASH phenotype when fed the same diets.CONCLUSION Substitution of Primex with palm oil promotes a similar phenotype of biopsyconfirmed NASH in ob/ob and C57BL/6J mice,making GAN diet-induced obese mouse models suitable for characterizing novel NASH treatments. | Michelle L Boland Denise Oro Kirstine S T■lb■l Sebastian T Thrane Jens Christian Nielsen Taylor S Cohen David E Tabor Fiona Fernandes Andrey Tovchigrechko Sanne S Veidal Paul Warrener Bret R Sellman Jacob Jelsing Michael Feigh Niels Vrang James L Trevaskis Henrik H Hansen | 2019 | World Journal of Gastroenterology2019，25，33： | 3 |
| 6 | A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope显示文摘 | Eric H. Choi Klaus Mergener Carol Semrad Laurel Fisher David R. Cave Milan Dodig Carol Burke Jonathan A. Leighton David Kastenberg Peter Simpson James Sul Kanishka Bhattacharya Roger Charles Lauren Gerson Luke Weber Glenn Eisen Warren Reidel John J. Vargo | 2013 | Gastrointestinal Endoscopy2013，，2： | 2 |
| 7 | Integrated testing of the NOXSO process: Simultaneous removed of SO2 and NOx from flue gas 显示文摘 | Yeh James T Ma Warren T Pennline Henry W | 1992 | Chem Eng Comm1992，14，： | 2 |
| 8 | Occurrence and Frequency of Arrhythmias in Hypertrophic Cardiomyopathy in Relation to Delayed Enhancement on Cardiovascular Magnetic Resonance显示文摘 | A. Selcuk Adabag Barry J. Maron Evan Appelbaum Caitlin J. Harrigan Jacqueline L. Buros C. Michael Gibson John R. Lesser Constance A. Hanna James E. Udelson Warren J. Manning Martin S. Maron | 2008 | Journal of the American College of Cardiology2008，，14： | 2 |
| 9 | Formation and Function of Acute Stroke–Ready Hospitals Within a Stroke System of Care Recommendations From the Brain Attack Coalition显示文摘 | Mark J. Alberts Lawrence R. Wechsler Mary E. Lee Jensen Richard E. Latchaw Todd J. Crocco Mary G. George James Baranski Robert R. Bass Robert L. Ruff Judy Huang Barbara Mancini Tammy Gregory Daryl Gress Marian Emr Margo Warren Michael D. Walker | 2013 | Stroke2013，，12： | 2 |
| 10 | A con- tinuum model of grain boundaries显示文摘 | Ryo Kobayashi James A Warren Craig Carter W | 2000 | Physica D2000，140，： | 1 |
| 11 | Hyperfibrinogenemia and Functional Outcome From Acute Ischemic Stroke显示文摘 | Gregory J. del Zoppo David E. Levy Warren W. Wasiewski Arthur M. Pancioli Andrew M. Demchuk James Trammel Bart M. Demaerschalk Markku Kaste Gregory W. Albers Eric B. Ringelstein | 2009 | Stroke2009，，5： | 1 |
| 12 | Discrete Time Modeling of Mean-Reverting Stochastic Processes for Real Option Val- uation显示文摘 | WARREN J H JAMES S D | 2008 | European journal of operational research2008，184，2： | 1 |
| 13 | Prevalence, Clinical Significance, and Natural History of Left Ventricular Apical Aneurysms in Hypertrophic Cardiomyopathy显示文摘 | Martin S. Maron John J. Finley J Martijn Bos Thomas H. Hauser Warren J. Manning Tammy S. Haas John R. Lesser James E. Udelson Michael J. Ackerman Barry J. Maron | 2008 | Circulation2008，，15： | 1 |
| 14 | Treatment of Focal Articular Cartilage Defects in the Knee显示文摘 | Robert A. Magnussen Warren R. Dunn James L. Carey Kurt P. Spindler | 2008 | Clinical Orthopaedics and Related Research2008，，： | 1 |
| 15 | Integrated testing of the NOXSO process: simultaneous removal of SO2 and NOx from flue gas 显示文摘 | James T Yeh Warren T Ma Henry W Pennline | 1992 | Chemical and Engineering Commication1992，14，： | 1 |
| 16 | Emergency Laparoscopycuurent best practice显示文摘 | James Kinross | 2006 | World Journal of Emergency Surgery2006，1，： | 1 |
| 17 | Antibiotic Use and the Risk of Flare of Inflammatory Bowel Disease显示文摘 | Faten N. Aberra Colleen M. Brensinger Warren B. Bilker Gary R. Lichtenstein James D. Lewis | 2005 | Clinical Gastroenterology and Hepatology2005，，5： | 1 |
| 18 | A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Stem Cells (Prochymal) After Acute Myocardial Infarction显示文摘 | Joshua M. Hare Jay H. Traverse Timothy D. Henry Nabil Dib Robert K. Strumpf Steven P. Schulman Gary Gerstenblith Anthony N. DeMaria Ali E. Denktas Roger S. Gammon James B. Hermiller Mark A. Reisman Gary L. Schaer Warren Sherman | 2009 | Journal of the American College of Cardiology2009，，24： | 1 |
| 19 | An efficient algorithm for solving the phase field crystal model显示文摘 | Mowei Cheng James A. Warren | 2008 | Journal of Computational Physics2008，，： | 1 |
| 20 | Assessment and Management of Acute Coronary Syndromes (ACS): A Canadian Perspective on Current Guideline-Recommended Treatment – Part 2: ST-Segment Elevation Myocardial Infarction显示文摘 | David H. Fitchett Pierre Theroux James M. Brophy Warren J. Cantor Jafna L. Cox Milan Gupta Heather Kertland Shamir R. Mehta Robert C. Welsh Shaun G. Goodman | 2011 | Canadian Journal of Cardiology2011，，6： | 1 |
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