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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Printed circuit board technology inspired stretchable circuits 显示文摘 | JAN V MARIO G FREDERICK B etal | 2012 | MRS Bulletin2012，37，3： | 1 |
| 3 | PRISMA-DB A parallel main memory relational DBMS 显示文摘 | PETER M G A CAREL A V D B JAN F | 1992 | IEEE Transactions on Knowledge and Data Engineering1992，4，6： | 1 |
| 4 | Effect of particle size of chemical mechanical polishing slurries for enhanced polishing with minimal defects显示文摘 | Basim G B A dler J J M aha Jan U | 2000 | Elecrochem Soc2000，147，35： | 1 |
| 5 | Application of ionic liquids in analytical chemistry 显示文摘 | LIU J F JAN A J JIANG G B | 2005 | Trends Anal Chem2005，24，1： | 1 |
| 6 | Carbon Trading: Accounting and Reporting Is- sues 显示文摘 | JAN B CARLOS L G | 2008 | European Accounting Review2008，17，4： | 1 |
| 7 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 8 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 9 | Serial blood lactate levels can predict the development of multiple organ failure following septic shock显示文摘 | Jan B Philippe G Michel C | 1996 | Am J Surg1996，171，2： | 1 |
| 10 | Effect of sorption kinetics on nickel toxicity in methanogenic granular sludge 显示文摘 | JAN B FERNANDO G F Alba B C | 2010 | Journal of Hazardous Materials2010，180，： | 1 |
| 11 | Yeast as an Unicellular Model System in Ecotoxicology and Xenobiochemistry显示文摘 | JAN A MARTIN B ANDREAS G | 1988 | Chemosphere1988，17，8： | 1 |
| 12 | Momentmethod analysis of side-wall inclined Slots in Rectangular Waveguide显示文摘 | Jan C G Hsu P Wu R B | | 0，，： | 1 |
| 13 | Variational Analysis of Inclined Slots in the Narrow Wall of a Rectangular Waveguide显示文摘 | Jan C G Wu R B Hsu P | | 0，，： | 1 |
| 14 | Pedormanee evaluation of local colour invariants显示文摘 | GERTJAN J B JAN M G | 2009 | Computer Vision and Image Understanding2009，113，1： | 1 |
| 15 | Maximum exposure levels for xylene, formaldehyde and acetaldehyde in cars 显示文摘 | Thomas S Hermann M B Jan G H | 2005 | Toxicology2005，206，3： | 1 |
| 16 | Effect of particle size、 chemical mechanical poishing slurries for enhanced polishing with minmial defects显示文摘 | Basmi G B Adler J J Maha jan U | | 0，，09： | 1 |
| 17 | The effect of oils on PAH,PCDD,PCDF and PCB emissions from a spark ignition enginefueled with leaded gasoline显示文摘 | JAN B ROM AN G STELLAN M | 2000 | Chemosphere2000，41，12： | 1 |
| 18 | Bactericidal activity of LFchimera is stronger and less sensitive to ionic strength than its constituent lactoferricin and lactoferrampin peptides显示文摘 | Jan G M B Regina A Kamran N | 2009 | Biochimie2009，91，： | 1 |
| 19 | A direct PCR detection method for clostridium tyrobutyricum spores in up to 100 Milliliters of raw milk显示文摘 | LIEVE M F H JAN H G E De B GUIDO M A V J W | 1995 | Appl Environ Microbiol1995，12，61： | 1 |
| 20 | Serial blood lactate levels Can predict the development of multiple organ failure following septic shock显示文摘 | Jan B Philippe G Michel C | 1996 | Am J Surg1996，171，2： | 1 |
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