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| 1 | 固定低剂量三联抗高血压药物与常规治疗对斯里兰卡轻度至中度高血压患者血压控制的疗效差异:一项随机临床试验显示文摘控制不良的高血压是全球领先的公共卫生问题,需要新的治疗策略。该研究评估低剂量三联抗高血压药物治疗是否能达到比常规治疗更好的血压控制。研究者纳入2016年2月至2017年5月在斯里兰卡11所城市医院诊所就诊的需要开始抗高血压治疗(未治疗的患者)或接受单药治疗的患者,进行低剂量三联降压与常规治疗比较的随机、开放性试验,随访至2017年10月。 | Web-ster R Salam A de Silva HA Selak V Stepien S Rajapakse S Amarasekara S Amarasena N Billot L de Silva AP Fernando M Guggilla R Jan S Jayawardena J Maulik PK Mendis S Munasinghe J Naik N Prabhakaran D Ranasinghe G Thom S Tisserra N Senaratne V Wijekoon S Wijeyasingam S Rodgers A Patel A 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 7 |
| 2 | Neonatal vitamin A injection promotes cattle muscle growth and increases oxidative muscle fibers显示文摘Background: Vitamin A and its metabolite,retinoic acid(RA),are important regulators of cell differentiation and organ morphogenesis.Its impact on beef cattle muscle growth remains undefined.Method: Angus steer calves were administrated with 0(control) or 150,000 IU vitamin A(retinyl palmitate in glycerol,i.m.) per calf at birth and 1 month of age.At 2 months of age,a biopsy of the Biceps femoris muscle was obtained to analyze the immediate effects of vitamin A injection on myogenic capacity of muscle cells.The resulting steers were harvested at 14 months of age.Results: Vitamin A administration increased cattle growth at 2 months.At 2 months of age,Vitamin A increased PAX7 positive satellite cells and the expression of myogenic marker genes including PAX7,MYF5,MYOD and MYOG.Muscle derived mononuclear cells were further isolated and induced myogenesis in vitro.More myotubes and a higher degree of myogenesis was observed in vitamin A groups.Consistently,vitamin A increased Latissimus dorsi(LD) muscle fiber size at harvest.In addition,vitamin A increased the ratio of oxidative type I and type IIA fibers and reduced the glycolic type IIX fibers.Furthermore,we found that RA,a key bioactive metabolite of vitamin A,activated PPARGC1 A promoter,which explains the upregulated expression of PPARGC1 A in skeletal muscle.Conclusion: Vitamin A administration to neonatal calves enhanced postnatal muscle growth by promoting myogenesis and increasing satellite cell density,accompanied with a shift to oxidative muscle fibers. | Bo Wang Wei Nie Xing Fu Jeanene M de Avila Yannan Ma Mei-Jun Zhu Martin Maquivar Steven M Parish Jan R Busboom Mark L Nelson Min Du | 2019 | Journal of Animal Science and Biotechnology2019，10，1： | 3 |
| 3 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 4 | Hepatitis B virus surface antigen can activate human monocyte-derived dendritic cells by nuclear factor kappa B and p38 mitogen-activated protein kinase medi- ated signaling显示文摘 | Jan R H Lin Y L Chen C J | 2012 | Microbiol Immunol2012，5610，： | 1 |
| 5 | Finding the most vital edge with respect to minimum spanning tree in weighted graphs显示文摘 | Hsu L H Jan R H Lee Y C | 1991 | Information Processing Letters1991，39，1： | 1 |
| 6 | The Tribological Performance of Uitra-hard Ceramic Composite Coating Obtained Through Micro arc Oxidation显示文摘 | KRISHNA L Rama SOMARAJU K R C SUNDARARA JAN G | 2003 | Surface and Coating Technology2003，，16： | 1 |
| 7 | Analysis of an indus- trial component commonality problem 显示文摘 | Jans R Degraeve Z Schepens L | 2008 | European Journal of Operational Research2008，186，2： | 1 |
| 8 | Development of human protein reference database as an initial platform for approaching systems biology in humans 显示文摘 | PERI S NAVARRO J D AMANCHY R KRISTIANSEN T Z JONNALAGADDA C K SURENDRANATH V NIRAN JAN V MUTHUSAMY B GANDHI T K GRONBORG M IBARROLA N DESHPANDE N SHANKER K SHIVASHANKAR H N RASHMI B P RAMYA M A ZHAO Z CHANDRIKA K N PADMA N HARSHA H C YATISH A J KAVITHA M P MENEZES M CHOUDHURY D R SURESH S GHOSH N SARAVANA R CHANDRAN S KRISHNA S JoY M ANAND S K MADAVAN V JOSEPH A WONG G W SCHIEMANN W P CONSTANTINESCU S N HUANG L KHOSRAVI-FAR R STEEN H TEWARI M GHAFFARI S BLOBE G C DANG C V GARCIA J G PEVSNER J JENSEN O N ROEPSTORFF P DESHPANDE K S CHINNAIYAN A M HAMOSH A CHAKRAVARTI A PANDEY A | 2003 | Genome Research2003，13，10： | 1 |
| 9 | Analysis of an in- dustrial component commonality problem 显示文摘 | Jans R J Degraeve Z Schepens L | 2008 | European Journal of Operational Research2008，186，： | 1 |
| 10 | Chemistry and biology of hop flavonoids显示文摘 | Jan F Stevens Cristobal L Miranda Donald R Buhler | 1998 | J Am Soc Brew Chem1998，，56： | 1 |
| 11 | Optimal wind-thermal coordination dispatch in isolated power systems with large integration of wind capacity 显示文摘 | Chen C L Lee T Y Jan R M | 2006 | Energy Con- version and Management2006，47，6： | 1 |
| 12 | The role of testosterone therapy in postmenopausal women : position statement of the north american menopause society 显示文摘 | Jan L Susan R Dennerstein L | 2005 | Menopause2005，12，5： | 1 |
| 13 | Finding the most vital edge with respect to minimum spanning tree in weighted graphs显示文摘 | Jan R H Lee Y C | 1991 | Information Processing Letters1991，39，5： | 1 |
| 14 | Detection of gas in sandstone reservoirs using AVO analysis: A 3-D seismic case history using the Geostack technique 显示文摘 | Jan L F George C S Peter J V Peter J S Philip R L | 1994 | Geophysics1994，59，： | 1 |
| 15 | Correntropy-based spectral characterization of respiratory patterns in patients with chronic heart failure显示文摘 | Garde A Srnmo L JanéR | 2010 | IEEE Trans Biomed Eng2010，57，8： | 1 |
| 16 | Detection of gas in sandstone reservoirs using AVO analysis:A 3-D seismic case history using the Geostack technique显示文摘 | Jan L F George C S Peter J V Peter J S Philip R L | 1994 | Geophysics1994，59，： | 1 |
| 17 | Study of non-enzymic browning in a-amino acid and c-aminobutyric acid/sugar model systems显示文摘 | LIEVE L INE R JAN A D | 2008 | Food Chemistry2008，111，： | 1 |
| 18 | Bedside placement of small - bowel feeding tubes in the intensive care unit显示文摘 | Jan Powers Chance R Bortenschlager L | 2003 | Critical CareNurse2003，23，1： | 1 |
| 19 | Characterization of chars from pyrolysis of lignin显示文摘 | Ramesh K Sharma Jan B Wooten Vicki L Baliga Xuehao Lin W Geoffrey Chan Mohammad R Hajaligol | 2004 | Fuel2004，，11： | 1 |
| 20 | Identification and in vitro biological activites of hop proanthocyanidins: inhibition of Nnos activity and scavenging of reactive nitrogen species显示文摘 | Jan F Stevens Cristobal L Miranda Kirsten R Wolthers | 2002 | Agricultural and Food Chemistry2002，50，： | 1 |
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