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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Gastric Adenocarcinoma Arising from Fundic Gland Polyps in a Patient with Familial Adenomatous Polyposis Syndrome显示文摘 | Garrean Sean Hering Justin Saied Abdul Jani Jigna Espat N Joseph | 2008 | The American Surgeon2008，，1： | 2 |
| 3 | Corneal avascularity is due to soluble VEGF receptor-1显示文摘 | Ambati BK Nozaki M Singh N Takeda A Jani PD Suthar T | 2006 | Nature2006，443，7114： | 1 |
| 4 | Clinical usefulness and prognostic value of el- evated cardiac troponin I levels in acute pulmonary embolism 显示文摘 | Mehta N J Jani K Khan IA | 2003 | Am Heart J2003，145，5： | 1 |
| 5 | Three-dimensional structures of thermophilic beta-1,4-xylanases from Chaetomium thermophilum and Nonomuraea flexuosa comparison of twelve xylanases in relation to their thermal stability显示文摘 | Hakulinen N Turunen O Janis J | 2003 | Eur J Biochem2003，270，： | 1 |
| 6 | Hypertension : salt restriction, sodi- um homeostasis, and other ions显示文摘 | Gupta N Jani KK Gupta N | 2011 | Indian J Med Sei2011，65，3： | 1 |
| 7 | Effect of some natural pesticides on entomogenous muscardine fungi 显示文摘 | Vyas R V Jani J J Yadav D N | 1992 | Indian J Exp Biol1992，30，5： | 1 |
| 8 | Three-dimensional structures of thermophilic beta-1,4-xylanases from Chaetomium thermophilum and Nonomuraeaflexuosa显示文摘 | Hakulinen N Turunen O Janis J | 2003 | Eur J Bioehem2003，270，： | 1 |
| 9 | Endoscopic ultrasound- guided fine-needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas: a multicenter experience 显示文摘 | Jani N Dewitt J Eloubeidi M | 2008 | Endoscopy2008，40，： | 1 |
| 10 | Fexofenadine in who doses in chronic what urticaria显示文摘 | Godse KV Nadkarni N J Jani G | 2010 | Journal of ipl Dermatol Online J2010，43，8： | 1 |
| 11 | Endoscopic uhrasound-guided fine-needle aspiration for diagnosis of solid psendopapillary tumors of the pancreas: a muhicenter experience 显示文摘 | Jani N Dewitt J Eloubeidi M | 2008 | Endoscopy2008，40，3： | 1 |
| 12 | Transition of Adolescents With Inflammatory Bowel Disease From Pediatric to Adult Care: A Survey of Adult Gastroenterologists显示文摘 | Elizabeth J Hait Renée M Barendse Janis H Arnold Clarissa Valim Bruce E Sands Joshua R Korzenik Laurie N Fishman | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，1： | 1 |
| 13 | Parenteral opioids in emergencymedicine: a systematic review of efficacy and safety 显示文摘 | Leila N Jani U Katri H | 2011 | ScandJPain2011，2，4： | 1 |
| 14 | Nonlinear viscoplastic and nonlinear viscoelastic material model for paper fiber composites in compression 显示文摘 | Lars-Olof N Janis V | 2006 | Composite Part A2006，37，： | 1 |
| 15 | Nonlinear viscoelastic behavior of paper fiber composites 显示文摘 | Lars-Olof N Janis V | 2005 | Composites Science and Technology2005，65，： | 1 |
| 16 | Clinical utility and prognostic val- ue of cardiac tmponin I in acute pulmonary embolism显示文摘 | Mehta N J Jani K Khan I A | 2003 | Am Hear J2003，145，： | 1 |
| 17 | Clinical characteristics and survival of children with Langerhans cell hystiocytosis 显示文摘 | Krstovski N Jani c D Dokmhnovic L | 2008 | Srp Arh Celok Lek2008，136，910： | 1 |
| 18 | Gastric Adenocarcinoma Arising from Fundic Gland Polyps in a Patient with Familial Adenomatous Polyposis Syndrome显示文摘 | Garrean Sean Hering Justin Saied Abdul Jani Jigna Espat N Joseph | 2008 | The American Surgeon2008，，1： | 1 |
| 19 | Parenteral opioids in emergencymedicine: a systematic review of efficacy and safety 显示文摘 | Leila N Jani U Katri H | 2011 | ScandJPain2011，2，4： | 1 |
| 20 | Endoscopic ultrasoundguided fine needle aspiration for diagnosis of solid pseudopapillary tumors of the pancreas a muhicenter experience 显示文摘 | Jani N Dewitt J Eloubeidi M | 2008 | Endoscopy2008，40，3： | 1 |
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