|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development显示文摘Angiogenesis,最新形成的血容器从先存在发芽的一个过程,为脊椎动物开发和成年动态平衡是重要的。以前的研究证明了 neuronal 指导分子 netrin-1 参予脉管的系统的 angiogenesis 和形态发生。Netrin-1 在 angiogenesis 展出双活动:支持或禁止 angiogenesis。netrin-1 的 anti-angiogenic 活动被 UNC5B 受体调停。然而, netrin-1 怎么支持 angiogenesis,仍然保持不清楚。这里,我们报导那 CD146,免疫球蛋白总科的 endothelial transmembrane 蛋白质,是为 netrin-1 的受体。Netrin-1 与高亲密关系绑在 CD146,导致 endothelial 房间激活并且以一种 CD146 依赖的方式的下游的发信号。在由特定的 anti-CD146 抗体的 netrin-CD146 相互作用的鼠科的内皮细胞层或混乱的 cd146 基因的有条件的大美人堵住或减少 netrin-1-induced angiogenesis。在 zebrafish 胚胎, downregulating 任何一个 netrin-1a 或 CD146 与惹人注目的类似导致脉管的缺点。而且,将宫外的脉管的发芽由 netrin-1 overexpression 导致了的 CD146 块击倒。一起,我们的数据揭开 CD146 在 angiogenesis 为 CD146 作为为 netrin-1 并且也的以前未知的受体揭示功能的 ligand,表明在脊椎动物开发期间在 angiogenesis 发信号的 netrin-CD146 的参与。 | Tao Tu Chunxia Zhang Huiwen Yan Yongting Luo Ruirui Kong Pushuai Wen Zhongde Ye Jianan Chen Jing Feng Feng Liu Jane Y Wu Xiyun Yan | 2015 | Cell Research2015，25，3： | 23 |
| 2 | Conserving Agricultural Heritage Systems through Tourism: Exploration of Two Mountainous Communities in China显示文摘Community plays an important role in the preservation of agricultural heritage system(AHS).Recently, many AHS have been valorized as interesting resources for rural tourism. The expectations are that tourism development(TD) can be supportive for the conservation of AHS while creating benefits for local communities. In this study,two mountainous pilot villages(Longxian and Xiaohuang) in a global conservation project for traditional agricutural systems – Globally Important Agricultural Heritage Systems(GIAHS) were selected to identify the relationship between AHS conservation and TD. The study undertook in-depth interviews,and questionnaires of village residents and informal discussions with local villagers. A t-test and a linear regression model were implemented to explore the comparative dimensions of the two communities with different geographical location, economic situation,and stage of TD. The research found some similarities and differences in the two mountainous communities during AHS conservation and TD. Firstly, AHS are preservaed well in both villages unconsiously, while the residents in Xiaohuang value more highly the heritage elements than the respondents in Longxian,and the villagers in Xiaohuang are more worried about their heritage system; Secondly, both villages expect lots of benefits from TD and they clearly perceive more positive than negative impact from tourism and thus approve TD, while the hugedifferent perception on transportation and accessibility in the two villages reflects the bottleneck of TD in Xiaohuang village. At the same time, the respondents from Xiaohuang perceive more positive and fewer negative impact from tourism than the respondents from Longxian. Thirdly, the respondents in the two villages all show positive attitudes towards participation in tourism mostly motivated by the high income expectation. The main factors to determine the community perception in two villages were also analyzed based on the data process. A location-based conceputal framework of AHS conservation in partnership with TD at community scale is proposed at the end of the paper. The dynamics of tourism development, that could enhance a better understanding of the complex relationship between conservation objectives and tourism development are discussed. | SUN Ye-hong Mary Jane DELA CRUZ MIN Qing-wen LIU Mou-cheng ZHANG Ling-yun | 2013 | Journal of Mountain Science2013，10，6： | 11 |
| 3 | New yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor for warm-white light-emitting diodes through single-emitting-center conversion显示文摘Phosphor-converted white light-emitting diodes for indoor illumination need to be warm-white(i.e.,correlated color temperature,4000 K)with good color rendition(i.e.,color rendering index.80).However,no single-phosphor,single-emitting-center-converted white light-emitting diodes can simultaneously satisfy the color temperature and rendition requirements due to the lack of sufficient red spectral component in the phosphors’emission spectrum.Here,we report a new yellow Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor that has a new orthorhombic lattice structure and exhibits a broad yellow photoluminescence band with sufficient red spectral component.Warm-white emissions with correlated color temperature,4000 K and color rendering index.80 were readily achieved when combining the Ba_(0.93)Eu_(0.07)Al_(2)O_(4) phosphor with a blue light-emitting diode(440–470 nm).This study demonstrates that warm-white light-emitting diodes with high color rendition(i.e.,color rendering index.80)can be achieved based on single-phosphor,single-emitting-center conversion. | Xufan Li John D Budai Feng Liu Jane Y Howe Jiahua Zhang Xiao-Jun Wang Zhanjun Gu Chengjun Sun Richard S Meltzer Zhengwei Pan | 2013 | Light(Science & Applications)2013，2，1： | 11 |
| 4 | Use of secondary preventive medications in patients with atherosclerotic disease in urban China: a cross-sectional study of 16 860 patients显示文摘 | LI Jing CHEN Yi-ping LI Xi Jane Armitage FENG Fang LIU Jia-min GAO Yan ZHANG Hai-bo ZHANG Dan HUNDEI Wuhan-bilige CHEN Zheng-ming CHEN Fang Jemma C Hopewell Elsa Valdes-Marquez Martin Landray JIANG Li-xin | 2012 | Chinese Medical Journal2012，，24： | 10 |
| 5 | Underuse of statins in patients with atherosclerotic ischemic stroke in China显示文摘 | LI Xi GAO Yan FENG Fang LIU Jia-min ZHANG Hai-bo ZHANG Dan HUNDEI Wu-han-bi-li-ge CHEN Fang CHEN Yi-ping CHEN Zheng-ming Martin Landray Jane Armitage JIANG Li-xin LI Li-ming | 2012 | Chinese Medical Journal2012，，10： | 9 |
| 6 | RNA-binding proteins in neurological diseases显示文摘Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and pathogenesis.RBPs are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of RNAs.Aberrant expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene function.RBPs have been associated with various diseases,including neurological diseases.Here,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases. | ZHOU HuaLin MANGELSDORF Marie LIU JiangHong ZHU Li WU Jane Y | 2014 | Science China(Life Sciences)2014，57，4： | 9 |
| 7 | Effect of oral epidermal growth factor on mucosal healing in rats with duodenal ulcer显示文摘AIM: To investigate the effect of epidermal growth factor (EGF) on mucosal healing in rats with duodenal ulcer.METHODS: Male Sprague-Dawley rats were randomly divided into sham operation without EGF, sham operation with EGF, duodenal ulcer without EGF, or duodenal ulcer with EGF groups. Additionally, normal rats without operation served as the control group. Duodenal ulcer was induced in rats by 300 mL/L acetic acid. Rats with EGF were orally administered at a dose of 60 μg/kg/day in drinking water on the next day of operation (day 1). Healing of duodenal ulcer was detected by haematoxylin and eosin staining. Cell growth of damaged mucosa was determined by the contents of nucleic acids and proteins. The level of EGF in duodenal mucosa was measured by ELISA.RESULTS: The pathological results showed that duodenal ulcer rats with EGF improved mucosal healing compared with those without EGF after day 5. Duodenal ulcer rats with EGF significantly increased duodenal DNA content compared with those without EGF on day 15 (6.44±0.54mg/g VS 1.45±0.52 mg/g mucosa, P<0.05). Duodenal RNA and protein contents did not differ between duodenal ulcer rats with and without EGF during the experimental period.Sham operation and duodenal ulcer rats with EGF significantly increased duodenal mucosal EGF content compared with those without EGF on day 5 (76.0±13.7 ng/g VS 35.7±12.9ng/g mucosa in sham operation rats, and 68.3±10.9 ng/gVS 28.3±9.2 ng/g mucosa in duodenal ulcer rats, P<0.05).CONCLUSION: Oral EGF can promote mucosal healing of the rats with duodenal ulcer by stimulating mucosal proliferation accompanied by an increase in mucosal EGF content. | Jane CJ Chao Kuo-Yu Liu Sheng-Hsuan Chen Chia-Lang Fang Chih-Wei Tsan | 2003 | World Journal of Gastroenterology2003，9，10： | 9 |
| 8 | TDP-43 regulates cancer-associated microRNAs显示文摘 | Xiaowei Chen Zhen Fan Warren McGee Mengmeng Chen Ruirui Kong Pushuai Wen Tengfei Xiao Xiaomin Chen Jianghong Liu Li Zhu Runsheng Chen Jane Y. Wu | 2018 | Protein & Cell2018，9，10： | 4 |
| 9 | Objective assessment of bradykinesia in Parkinson’s disease using evolutionary algorithms:clinical validation显示文摘Background:There is an urgent need for developing objective,effective and convenient measurements to help clinicians accurately identify bradykinesia.The purpose of this study is to evaluate the accuracy of an objective approach assessing bradykinesia in finger tapping(FT)that uses evolutionary algorithms(EAs)and explore whether it can be used to identify early stage Parkinson’s disease(PD).Methods:One hundred and seven PD,41 essential tremor(ET)patients and 49 normal controls(NC)were recruited.Participants performed a standard FT task with two electromagnetic tracking sensors attached to the thumb and index finger.Readings from the sensors were transmitted to a tablet computer and subsequently analyzed by using EAs.The output from the device(referred to as'PD-Monitor')scaled from−1 to+1(where higher scores indicate greater severity of bradykinesia).Meanwhile,the bradykinesia was rated clinically using the Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale(MDS-UPDRS)FT item.Results:With an increasing MDS-UPDRS FT score,the PD-Monitor score from the same hand side increased correspondingly.PD-Monitor score correlated well with MDS-UPDRS FT score(right side:r=0.819,P=0.000;left side:r=0.783,P=0.000).Moreover,PD-Monitor scores in 97 PD patients with MDS-UPDRS FT bradykinesia and each PD subgroup(FT bradykinesia scored from 1 to 3)were all higher than that in NC.Receiver operating characteristic(ROC)curves revealed that PD-Monitor FT scores could detect different severity of bradykinesia with high accuracy(≥89.7%)in the right dominant hand.Furthermore,PD-Monitor scores could discriminate early stage PD from NC,with area under the ROC curve greater than or equal to 0.899.Additionally,ET without bradykinesia could be differentiated from PD by PD-Monitor scores.A positive correlation of PD-Monitor scores with modified Hoehn and Yahr stage was found in the left hand sides.Conclusions:Our study demonstrated that a simple to use device employing classifiers derived from EAs could not only be used to accurately measure different severity of bradykinesia in PD,but also had the potential to differentiate early stage PD from normality. | Chao Gao Stephen Smith Michael Lones Stuart Jamieson Jane Alty Jeremy Cosgrove Pingchen Zhang Jin Liu Yimeng Chen Juanjuan Du Shishuang Cui Haiyan Zhou Shengdi Chen | 2018 | Translational Neurodegeneration2018，7，1： | 3 |
| 10 | Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett’s esophagus显示文摘 | M. Kareem Shariff Elizabeth L. Bird-Lieberman Maria O'Donovan Zarah Abdullahi Xinxue Liu Jane Blazeby Rebecca Fitzgerald | 2012 | Gastrointestinal Endoscopy2012，，5： | 2 |
| 11 | USP33, a new player in lung cancer, mediates Slit-Robo signaling显示文摘Ubiquitin 特定的朊酶(USP33 ) 33 是调整多样的细胞的过程的多功能的蛋白质。在肺癌症的 USP33 的表示和角色仍然保持未经勘探。在这研究,我们证明 USP33 在肺癌症病人的多重队是下面调整的, USP33 的那低表情与差的预后被联系。USP33 调停 Slit-Robo 在肺癌症房间移植发信号。USP33 的 Downregulation 在肺癌症房间减少 Robo1 的蛋白质稳定性,提供为在调停的 USP33 功能的以前未知的机制在肺癌症房间的裂缝活动。一起拿, USP33 是在调整 Slit-Robo 发信号的肺癌症的一个新播放器。我们的数据建议 USP33 可以作为一个预示的标记是为有潜力的肺癌症的候选人肿瘤 suppressor。 | Pushuai Wen Ruirui Kong Jianghong Liu Li Zhu Xiaoping Chen Xiaofei Li Yongzhan Nie Kaichun WU Jane Y. Wu | 2014 | Protein & Cell2014，5，9： | 2 |
| 12 | Validation and Implementation of Targeted Capture and Sequencing for the Detection of Actionable Mutation, Copy Number Variation, and Gene Rearrangement in Clinical Cancer Specimens显示文摘 | Colin C. Pritchard Stephen J. Salipante Karen Koehler Christina Smith Sheena Scroggins Brent Wood David Wu Ming K. Lee Suzanne Dintzis Andrew Adey Yajuan Liu Keith D. Eaton Renato Martins Kari Stricker Kim A. Margolin Noah Hoffman Jane E. Churpek Jonathan | 2014 | The Journal of Molecular Diagnostics2014，，1： | 1 |
| 13 | AMPK interacts with DSCAM and plays an important role in Netrin-1 induced neurite outgrowth显示文摘Down syndrome cell adhesion molecule(DSCAM)acts as a netrin-1 receptor and mediates attractive response of axons to netrin-1 in neural development.However,the signaling mechanisms of netrin-DSCAM remain unclear.Here we report that AMP-activated protein kinase(AMPK)interacts with DSCAM through itsγsubunit,but does not interact with DCC(deleted in co-lorectal cancer),another major receptor for netrin-1.Netrin-treatment of cultured cortical neurons leads to increased phosphorylation of AMPK.Both AMPK mu-tant with dominant-negative effect and AMPK inhibitor can significantly suppress netrin-1 induced neurite outgrowth.Together,these findings demonstrate that AMPK interacts with DSCAM and plays an important role in netrin-1 induced neurite outgrowth.Our study uncovers a previously unknown component,AMPK,in netrin-DSCAM signaling pathway. | Kun Zhu Xiaoping Chen Jianghong Liu Haihong Ye Li Zhu Jane Y.Wu | 2013 | Protein & Cell2013，4，2： | 1 |
| 14 | Treatment of semi-conductor wastewater by dissolved air flotation显示文摘 | Chuang T C Huang C Jane Liu J C | 2002 | Journalof Environmental Engineeering2002，128，10： | 1 |
| 15 | Chloroplast genome aberration in micropropagation derived albino Bambusa edulis mutants,abl and ab2 显示文摘 | Liu Nien-Tsu Jane Wann-Neng Tsay Hsin-Sheng | 2007 | Plant Cell Tissue and Organ Culture2007，88，： | 1 |
| 16 | Randomized crossover study comparing efficacy of transnasal endoscopy with that of standard endoscopy to detect Barrett’s esophagus显示文摘 | M. Kareem Shariff Elizabeth L. Bird-Lieberman Maria O’Donovan Zarah Abdullahi Xinxue Liu Jane Blazeby Rebecca Fitzgerald | 2012 | Gastrointestinal Endoscopy2012，，： | 1 |
| 17 | Effects of foliage clumping on the estimation of global terrestrial gross primary productivity显示文摘 | Chen Jing M. Mo Gang Pisek Jan Liu Jane Deng Feng Ishizawa Misa Chan Douglas | 2012 | EN2012，，1： | 1 |
| 18 | Chloroplast genome aberration in micropropagation derived albino Bambusa edulis mutants,ab1 and ab2 显示文摘 | Liu N T Jane W N Tsay H S Wu H Chang W C Lin C C | 2007 | Plant Cell Tissue and Organ Culture2007，88，2： | 1 |
| 19 | Differential protein expression of two photosystem II subunits,PsbO and PsbP,in an albino mutant of Bambusa edulis with chloroplast DNA aberration显示文摘 | Lin C S Liu N T Liao D C Yu J S Tsao H Lin C H Sun C W Jane W N Tsay H S Chen J J W Lai E M Lin N S Chang W C Lin C C | 2008 | AMER SOC Horticulture Science2008，133，2： | 1 |
| 20 | Dscam mutation leads to hydrocephalus and decreased motor function显示文摘The nervous system is one of the most complicated organ systems in invertebrates and vertebrates.Down syndrome cell adhesion molecule(DSCAM)of the immunoglobulin(Ig)superfamily is expressed widely in the nervous system during embryonic development.Previous studies in Drosophila suggest that Dscam plays important roles in neural development including axon branching,dendritic tiling and cell spacing.However,the function of the mammalian DSCAM gene in the formation of the nervous system remains unclear.Here,we show that Dscam^(del17) mutant mice exhibit severe hydrocephalus,decreased motor function and impaired motor learning ability.Our data indicate that the mammalian DSCAM gene is critical for the formation of the central nervous system. | Yiliang Xu Haihong Ye Yan Shen Qi Xu Li Zhu Jianghong Liu Jane Y.Wu | 2011 | Protein & Cell2011，2，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员