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| 1 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 2 | Adjuvant dendritic cell-based tumour vaccination for children with malignant brain tumours显示文摘 | Ardon H De Vleeschouwer S Van Calenbergh F Claes L Kramm CM Rutkowski S Wolff JE Van Gool SW. | 2010 | 中国神经肿瘤杂志2010，8，1： | 3 |
| 3 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Adaptive randomized study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxaeitabine and idarubicin in untreated patient 50 years or older with adverse karyotype acute myeloid leukemia 显示文摘 | Giles F J Kantar JHM Cortes JE | 2003 | J Clin Oncol2003，21，9： | 1 |
| 6 | One-year follow-up of epithelial corneal cell sheet allografts mounted on platelet poor plasma in rabbits 显示文摘 | Luengo Gimeno F Lavigne V Gatto S Croxatto JO Correa L Gallo JE | 2009 | Mol Vis2009，15，： | 1 |
| 7 | Losartan titration versus diuretic combination in type 2 diabetics patients 显示文摘 | de Pablos-Velasco PL Pazos Toral F Esmatjes JE etal | 2002 | J Hypertens2002，20，4： | 1 |
| 8 | Reactive oxygen species mediate endothelial dependent relaxations in tetrahydrobiopterin-deficient mice 显示文摘 | Cosentino F Barker JE Brand MP | 2001 | Arterioscler Thromb VASc Biol2001，21，4： | 1 |
| 9 | Physiological and pathologi- cal regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors显示文摘 | Dumont JE Lamy F Roger P | 1992 | Physiol Rev1992，72，3： | 1 |
| 10 | Acquisition of fear extinction requiresactivation of NR2B-containlng NMDA receptors in the lateralamygdala 显示文摘 | Sotres-Bayon F Bush DE LeDoux JE | 2007 | Neurepsychopharmacology2007，32，9： | 1 |
| 11 | Isometric exercise increases strength and does not produce sustained creatinine phosphokinase increases in a patient with polymyositis显示文摘 | Hicks JE Miller F Plotz P | | 0，，08： | 1 |
| 12 | The Bcl-2 family reunion显示文摘 | Chipuk JE Moldoveanu T Llambi F | 2010 | Mol Cell2010，37，3： | 1 |
| 13 | Comparison of coronary-artery bypass surgery and stenting for the treatment ofmultivessel disease显示文摘 | Serruys PW Unger F Sousa JE | 2001 | N Engl J Med2001，344，： | 1 |
| 14 | Postpartum major depression at six weeks in primary health care: prevalence and associated factors 显示文摘 | Nakku JE Nakasi G Mirembe F | 2006 | Afr Health Sci2006，6，4： | 1 |
| 15 | Phase II trial of weekly vinorelbine and trastuzumab as first-line therapy in patients with HER-2 ( + ) metastatic breast cancer 显示文摘 | Jahanzeb M Mortimer JE Yunus F | 2002 | Oncologist2002，7，5： | 1 |
| 16 | Doubled haploid lines of Brassica carinata with modified erucic acid content through mutagenesis by EMS treatment of isolated micrespores显示文摘 | Barro F Fernandez JE Dela MV | 2001 | Plant Breeding2001，120，： | 1 |
| 17 | FastMR arthrography using VIBE sequences to evaluate the rotator cuff显示文摘 | Vandevenne JE Vanhoenacker F Mahachie John JM | 2009 | Skeletal Radiol2009，38，7： | 1 |
| 18 | Linkage between cellular communications,energy utilization,and proliferation in metastatic neuroendocrine cancers显示文摘 | Ippolito JE Merritt ME Backhed F | 2006 | Proc Natl Acad Sci U S A2006，103，12： | 1 |
| 19 | The role of parathyroid hor- mone-related protein in the regulation of osteoclastogenesis by ce- mentoblasts显示文摘 | Boabaid F Berry JE Koh AJ | 2004 | J Periodontol2004，75，9： | 1 |
| 20 | Evolution and prognosis of necrotic primary teeth after pulpectomy显示文摘 | Mendoza AM Reina JE Garcia - Godoy F | 2010 | Am J Dent2010，23，5： | 1 |
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