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| 1 | 抗生素相关性腹泻的治疗 微生态制剂可能有助于预防显示文摘腹泻是抗生素治疗过程中一种常见的不良作用。5%~30%的患者在抗生素治疗早期或治疗结束后2个月内会发生抗生素相关性腹泻。抗生素相关性腹泻的发生率取决于对腹泻的定义、所使用的抗生素种类和宿主的个体因素。 | FrédéricBarbut Jean Luc Meynard 范洪伟 | 2003 | 英国医学杂志中文版2003，6，1： | 15 |
| 2 | Usefulness of staging systems and prognostic scores for hepatocellular carcinoma treatments显示文摘Therapeutic management of hepatocellular carcinoma(HCC) is quite complex owing to the underlying cirrhosis and portal vein hypertension. Different scores or classification systems based on liver function and tumoral stages have been published in the recent years. If none of them is currently 'universally' recognized, the Barcelona Clinic Liver Cancer(BCLC) staging system has become the reference classification system in Western countries. Based on a robust treatment algorithm associated with stage stratification, it relies on a high level of evidence. However, BCLC stage B and C HCC include a broad spectrum of tumors but are only matched with a single therapeutic option. Some experts have thus suggested to extend the indications for surgery or for transarterial chemoembolization. In clinical practice, many patients are already treated beyond the scope of recommendations. Additional alternative prognostic scores that could be applied to any therapeutic modality have been recently proposed. They could represent complementary tools to the BCLC staging system and improve the stratification of HCC patients enrolled in clinical trials, as illustrated by the NIACE score. Prospective studies are needed to compare these scores and refine their role in the decision making process. | Xavier Adhoute Guillaume Penaranda Jean Luc Raoul Patrice Le Treut Emilie Bollon Jean Hardwigsen Paul Castellani Hervé Perrier Marc Bourlière | 2016 | World Journal of Hepatology2016，8，17： | 7 |
| 3 | Portopulmonary hypertension and hepatopulmonary syndrome显示文摘Portopulmonary hypertension(POPH) and hepatopulmonary syndrome(HPS) are two frequent complications of liver disease, with prevalence among liver transplant candidates of 6% and 10%, respectively. Both conditions result from a lack of hepatic clearance of vasoactive substances produced in the splanchnic territory. Subsequently, these substances cause mainly pulmonary vascular remodeling and some degree of vasoconstriction in POPH with resulting elevated pulmonary pressure and right ventricular dysfunction. In HPS the vasoactive mediators cause intrapulmonary shunts with hypoxemia. Medical treatment is disappointing overall. Whereas liver transplantation(LT) results in the disappearance of HPS within six to twelve months, its effect on POPH is highly unpredictable. Modern strategies in managing HPS and POPH rely on a thorough screening and grading of the disease's severity, in order to tailor the appropriate therapy and select only the patients who will benefit from LT. The anesthesiologist plays a central role in managing these high-risk patients. Indeed, the important hemodynamic and respiratory modifications of the perioperative period mustbe avoided through continuation of the preoperatively initiated drugs, appropriate intraoperative monitoring and proper hemodynamic and respiratory therapies. | Florence Aldenkortt Marc Aldenkortt Laurence Caviezel Jean Luc Waeber Anne Weber Eduardo Schiffer | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 4 | Liver transplantation for acute hepatic failure due to chemotherapy-induced HBV reactivation in lymphoma patients显示文摘Hepatitis B (HBV) reactivation induced by chemotherapy is problem encountered recently in the management of malignant diseases.Chemotherapy-induced HBV reactivation may ultimately lead to terminal acute liver failure.Liver transplantation (LT) currently remains the only definitive treatment option for such cases,but is generally denied to patients suffering from malignancy.Here,the authors describe 2 cases of cancer-free and HBV graft re-infection-free survival after LT performed for terminal liver failure arising from HBV reactivation induced by chemotherapy for advanced stage lymphoma.These 2 cases,and some other reports in the literature,may suggest that patients suffering from hematologic malignancies and terminal liver disease can be considered for LT if the prognosis of their hematologic malignancy is good. | Timothée Noterdaeme Luc Longrée Christian Bataille Arnaud Deroover Anne Lamproye Jean Delwaide Yves Beguin Pierre Honoré Olivier Detry | 2011 | World Journal of Gastroenterology2011，17，25： | 6 |
| 5 | 木材声学-超声波分等检测技术及工业应用显示文摘介绍了在应力波-超声波技术基础上发展起来的木材声学-超声波分等检测技术。通过测量超声波的传播速度以及一定时域内的传播能量,建立关系模型,对木材的抗弯弹性模量(MOE)和抗弯强度(bσ)进行评估。该技术可在木结构建筑设计、木结构建筑现场调查、森林质量控制和管理等领域广泛应用。 | SANDOZ Jean Luc 殷亚方 BENOIT Y 姜笑梅 | 2007 | 木材工业2007，21，6： | 3 |
| 6 | 法国野猪中Rickettsia raoultii的流行(英文)显示文摘目的调查和鉴定法国野猪身上Rickettsia raoultii的流行情况以及野猪作为贮存宿主所起的作用。方法收集法国2007年9月到11月的野猪身上的边缘革蜱163只。应用柠檬酸合成酶基因和外膜蛋白基因进行实时定量PCR、普通PCR技术及序列分析方法检测立克次体。结果 113只(69.3%)边缘革蜱立克次检测阳性。进一步鉴定为斑点热的两类病原,其中R.raoultii占57.5%(存在于65只蜱中)和R.slovaca占42.5%(存在于48只蜱中)。结论证明R.raoultii是野猪身上边缘革蜱的主要病原,边缘革蜱中感染率较高。应警惕野猪对立克次体的传播作用。 | 曲芬 Jean Luc Llabers Oleg Mediannikov Jean-Marc Rolain | 2010 | 传染病信息2010，23，1： | 3 |
| 7 | Epidemiology of inflammatory bowel diseases: New insights from a French population-based registry (EPIMAD)显示文摘 | Corinne Gower-Rousseau Francis Vasseur Mathurin Fumery Guillaume Savoye Julia Salleron Luc Dauchet Dominique Turck Antoine Cortot Laurent Peyrin-Biroulet Jean Frédéric Colombel | 2012 | Digestive and Liver Disease2012，，： | 3 |
| 8 | 平整度和表面控制在钢材精加工领域的发展显示文摘叙述了KvaernerMetals在过去、现在以及不久的将来对优质冷轧板带加工领域的发展所作的贡献,讨论了冷轧机的设计,镀锡板张力矫直的进展,平整。 | Legoupil Jean Luc | 1999 | 钢铁1999，34，6： | 2 |
| 9 | Insulin-mimetic compound hexaquis(benzylammonium) decavanadate is antilipolytic in human fat cells显示文摘AIM To assess in rodent and human adipocytes the antilipolytic capacity of hexaquis(benzylammonium) decavanadate(B6V10), previously shown to exert antidiabetic effects in rodent models, such as lowering free fatty acids(FFA) and glucose circulating levels.METHODS Adipose tissue(AT) samples were obtained after informed consent from overweight women undergoing plastic surgery. Comparison of the effects of B6V10 and reference antilipolytic agents(insulin,benzylamine,vanadate) on the lipolytic activity was performed on adipocytes freshly isolated from rat, mouse and human AT. Glycerol release was measured using colorimetric assay as an index of lipolytic activity. The influence of B6V10 and reference agents on glucose transport into human fat cells was determined using the radiolabelled 2-deoxyglucose uptake assay.RESULTS In all the species studied, B6V10 exhibited a dosedependent inhibition of adipocyte lipolysis when triglyceride breakdown was moderately enhanced by β-adrenergic receptor stimulation. B6V10 exerted on human adipocyte a maximal lipolysis inhibition of glycerol release that was stronger than that elicited by insulin. However, B6V10 did not inhibit basal and maximally stimulated lipolysis. When incubated at dose ≥ 10 μmol/L, B6V10 stimulated by twofold the glucose uptake in human fat cells, but-similarly to benzylamine-without reaching the maximal effect of insulin, while it reproduced one-half of the insulin-stimulation of lipogenesis in mouse fat cells. CONCLUSION B6V10 exerts insulin-like actions in adipocytes, including lipolysis inhibition and glucose transport activation. B6V10 may be useful in limiting lipotoxicity related to obesity and insulin resistance. | Christian Carpéné Silvia Garcia-Vicente Marta Serrano Luc Marti ChloéBelles Miriam Royo Jean Galitzky Antonio Zorzano Xavier Testar | 2017 | World Journal of Diabetes2017，8，4： | 2 |
| 10 | Radioembolisation and portal vein embolization before resection of large hepatocellular carcinoma显示文摘Resectability of hepatocellular carcinoma in patients with chronic liver disease is dramatically limited by the need to preserve sufficient remnant liver in order to avoid postoperative liver insufficiency. Preoperative treatments aimed at downsizing the tumor and promoting hypertrophy of the future remnant liver may improve resectability and reduce operative morbidity. Here we report the case of a patient with a large hepatocellular carcinoma arising from chronic liver disease. Preoperative treatment, including tumor downsizing with transarterial radioembolization and induction of future remnant liver hypertrophy with right portal vein embolization, resulted in a 53% reduction in tumor volume and compensatory hypertrophy in the contralateral liver. The patient subsequently underwent extended right hepatectomy with no postoperativesigns of liver decompensation. Pathological examination demonstrated a margin-free resection and major tumor response. This new therapeutic sequence, combining efficient tumor targeting and subsequent portal vein embolization, could improve the feasibility and safety of major liver resection for hepatocellular carcinoma in patients with liver injury. | Fikri Bouazza Arthur Poncelet Camilo Alejandro Garcia Philippe Delatte Jean Luc Engelhom Maria Gomez Galdon Amélie Deleporte Alain Hendlisz Bruno Vanderlinden Patrick Flamen Vincent Donckier | 2015 | World Journal of Gastroenterology2015，21，32： | 2 |
| 11 | Methylome and transcriptome data integration reveals potential roles of DNA methylation and candidate biomarkers of cow Streptococcus uberis subclinical mastitis显示文摘Background:Mastitis caused by different pathogens including Streptococcus uberis(S.uberis)is responsible for huge economic losses to the dairy industry.In order to investigate the potential genetic and epigenetic regulatory mecha‑nisms of subclinical mastitis due to S.uberis,the DNA methylome(whole genome DNA methylation sequencing)and transcriptome(RNA sequencing)of milk somatic cells from cows with naturally occurring S.uberis subclinical mastitis and healthy control cows(n=3/group)were studied.Results:Globally,the DNA methylation levels of CpG sites were low in the promoters and first exons but high in inner exons and introns.The DNA methylation levels at the promoter,first exon and first intron regions were nega‑tively correlated with the expression level of genes at a whole‑genome‑wide scale.In general,DNA methylation level was lower in S.uberis‑positive group(SUG)than in the control group(CTG).A total of 174,342 differentially methylated cytosines(DMCs)(FDR<0.05)were identified between SUG and CTG,including 132,237,7412 and 34,693 DMCs in the context of CpG,CHG and CHH(H=A or T or C),respectively.Besides,101,612 methylation haplotype blocks(MHBs)were identified,including 451 MHBs that were significantly different(dMHB)between the two groups.A total of 2130 differentially expressed(DE)genes(1378 with up‑regulated and 752 with down‑regulated expression)were found in SUG.Integration of methylome and transcriptome data with MethGET program revealed 1623 genes with signifi‑cant changes in their methylation levels and/or gene expression changes(MetGDE genes,MethGET P‑value<0.001).Functional enrichment of genes harboring≥15 DMCs,DE genes and MetGDE genes suggest significant involvement of DNA methylation changes in the regulation of the host immune response to S.uberis infection,especially cytokine activities.Furthermore,discriminant correlation analysis with DIABLO method identified 26 candidate biomarkers,including 6 DE genes,15 CpG‑DMCs and 5 dMHBs that discriminated between SUG and CTG.Conclusion:The integration of methylome and transcriptome of milk somatic cells suggests the possible involve‑ment of DNA methylation changes in the regulation of the host immune response to subclinical mastitis due to S.uberis.The presented genetic and epigenetic biomarkers could contribute to the design of management strategies of subclinical mastitis and breeding for mastitis resistance. | Mengqi Wang Nathalie Bissonnette Mario Laterriere Pier‑Luc Dudemaine David Gagne Jean‑Philippe Roy Xin Zhao Marc‑Andre Sirard Eveline M.Ibeagha‑Awemu | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 2 |
| 12 | Motility of the Roux-en-Y hepaticojejunostomy in asymptomatic patients显示文摘 | Isabelle Le Blanc-Louvry Philippe Ducrotté Jean Luc Manouvrier Christophe Peillon Jacques Testart Philippe Denis | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 13 | WAHLENBERGIOSIDE, A PHENYLPROPANOID GLUCOSIDE FROM WAHLENBERGIA MARGINATA 显示文摘 | WEI GUANG MA REN XIANG TAN NICOLA FUZZATI JEAN -LUC WOLFENDER | 1997 | Phytochemistry1997，45，2： | 1 |
| 14 | Early and late outcome after elective cardiac surgery in patients with cirrhosis显示文摘 | Philippe Bizouarn Antoine Ausseur Pascal Desseigne Yann Le Teurnier Bertrand Nougarede Michel Train Jean Luc Michaud | 1999 | The Annals of Thoracic Surgery1999，，5： | 1 |
| 15 | Expedited blood pressure control with initial angiotensin II antagonist/diuretic therapy compared with stepped-care therapy in patients with ambulatory systolic hypertension显示文摘 | Yves Lacourcière Luc Poirier Jean Lefebvre | 2007 | Canadian Journal of Cardiology2007，，5： | 1 |
| 16 | Systemic Infection Related to Endocarditis on Pacemaker Leads: Clinical Presentation and Management显示文摘 | Didier Klug Dominique Lacroix Christine Savoye Luc Goullard Daniel Grandmougin Jean Luc Hennequin Salem Kacet Jean Lekieffre | 1997 | Circulation1997，，8： | 1 |
| 17 | Finite Element Simulation of Spring Back in Sheet Metal Forming显示文摘 | Luc P Jean P P | 2002 | Journal of Materials Processing Technology2002，，： | 1 |
| 18 | Evidence for global ranoff increase related to climate warming显示文摘 | David Labat Yves Goddéris Jean Luc Probst | 2004 | Advances in Water Resources2004，27，： | 1 |
| 19 | A Double-blind Comparison of 0.125% Ropivacaine with Sufentanil and 0.125% Bupivacaine with Sufentanil for Epidural Labor Analgesia显示文摘 | Philippe Gautier Marc De Kock Albert Van Steenberge Dominique Miclot Luc Fanard Jean Luc Hody | 1999 | Anesthesiology1999，，3： | 1 |
| 20 | Yttrium and rare earth elements in fluids from various deep - sea hydrothermal systems显示文摘 | Eric Douvilie Philippe Bienvenu Jean Luc Charlou | 1999 | Geochimica et Cosmochimica Acta1999，63，5： | 1 |
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