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	题名	作者	年代	出处	被引量
1	Risk Factors for Hepatocellular Carcinoma in Patients With Alcoholic or Viral C Cirrhosis显示文摘	Gisèle N’Kontchou Jacques Paries Myint Tin Tin Htar Nathalie Ganne–Carrie Lydie Costentin Véronique Grando–Lemaire Jean–Claude Trinchet Michel Beaugrand	2006	Clinical Gastroenterology and Hepatology2006，，8：	2
2	Natural History of Pediatric Crohn’s Disease: A Population-Based Cohort Study显示文摘	Gwenola Vernier–Massouille Mamadou Balde Julia Salleron Dominique Turck Jean Louis Dupas Olivier Mouterde Véronique Merle Jean Louis Salomez Julien Branche Raymond Marti éric Lerebours Antoine Cortot Corinne Gower–Rousseau Jean Frédéric Colombel	2008	Gastroenterology2008，，4：	2
3	Liver myofibroblasts activate protein C and respond to activated protein C显示文摘AIM:To study the protein C activation system in human liver myofibroblasts,and the effects of activated protein C(APC)on these cells.METHODS:Human liver myofibroblasts were obtained by outgrowth.Expression of protease activated receptor 1(PAR-1),endothelial protein C receptor(EPCR) and thrombomodulin(TM)was analyzed by flow cytometry.Extracellular signal-regulated kinase(ERK)1/2 activation was assessed by Western blotting using anti-phospho-ERK antibodies.Collagen synthesis was studied with real-time reverse transcription-polymerase chain reaction(RT-PCR).Activation of protein C was studied by incubating liver myofibroblasts with zymogen protein C in the presence of thrombin and detecting the generation of APC with a colorimetric assay using a peptide substrate. RESULTS:Primary cultures of human liver myofibroblasts expressed EPCR on their surface,together with PAR-1 and TM.This receptor system was functional since exposure of myofibroblasts to APC inducedERK1/2 phosphorylation in a dose-and time-dependent manner.Furthermore,APC significantly upregulated the expression of collagen mRNA,as shown by real-time RT-PCR.Collagen upregulation was controlled through the ERK pathway as it was inhibited when using the mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor PD98059.Finally,using a cell-based colorimetric assay,we showed that intact myofibroblasts converted protein C into APC in the presence of thrombin.CONCLUSION:These data suggest that APC is a new modulator of liver myofibroblast activity and contributes to the pathophysiology of chronic liver diseases.	Jennifer Gillibert-Duplantier Anne Rullier Véronique Neaud Walter Kisiel Jean Rosenbaum	2010	World Journal of Gastroenterology2010，16，2：	2
4	Microleakage of class V composite restorations following Er:YAG and Nd:YAP laser irradiation compared to acid-etch: an in vitro study显示文摘	Armengol V Jean A Enkel B	2002	Lasers Med Sci2002，17，2：	1
5	Level of farm sector productivity : an international com- parison显示文摘	V Eldon Ball Jean - Christophe Bureau Jean - Pierre Butault	2001	General2001，，8：	1
6	Analog sensor design proposal for laser Doppler velocimetry 显示文摘	Alain L D Guy P Jean C V	2004	IEEE Sensors Journal2004，4，2：	1
7	Microbial hydrolysis of methyl aromatic esters by Burkholderia cepacia iso- lated from soil显示文摘	Geraldine P Danielle V Jean B	2001	FEMS Microbiology Ecology2001，37，：	1
8	Association between insulin-like growth factor-1 and bone mineral density in older women and men:the Framingham heart study显示文摘	Jean AL Clifford JR Marjolein V	1998	J Clin Endocrinol Metab1998，83，12：	1
9	Analog sensor design proposal for laser doppler velocimetry显示文摘	ALAIN L D GUY P JEAN C V	2004	IEEE Sensors Journal2004，4，2：	1
10	In vitro models to study wound healing fibroblasts显示文摘	Moulin V Castilloux G Jean A	1996	Burns1996，22，5：	1
11	Photocatalytic Degradation of Dyes in Water:Case Study of Indigo and of Indigo Ocarmine显示文摘	Manon V Guillard C Jean M H	2001	J Catal2001，201，1：	1
12	Long-term (up to 18 years ) effects on GH/IGF-1 hylpersecretion and tumor size of primary somatostatin analogue (SSTa) therapy in patients with GH-secreting pituitary adenoma responsive to SSTa 显示文摘	Jean CM Delphine V Maria M	2007	Clinic Endnerinology2007，67，5：	1
13	A multicenter,double-blind safety study of QR-333for the treatment of symptomatic diabetic peripheral neuropathy,apreliminary report显示文摘	Paul V Claude LD Jean LR	2005	Diabetes Complication2005，19，5：	1
14	Adeno-associated virus (AAV) vectors achieve prolonged transgene expression in mouse myocardium and arteries in vivo: a comparative study with adenovirus vectors显示文摘	GIUSEPPE V HANSRUEDI B JEAN D	2003	Int J Cardiol2003，90，223：	1
15	Root type: A generic model to depict and analyze the root system architecture显示文摘	Pages L Gilles V Jean L D	2004	Plant and Soil2004，258，1：	1
16	A fully automatable enzymatic method for DNA extraction from plant tissues显示文摘	JEAN F M OLGA S LORENE A ALEXANDER V M ARKADY S	2005	BMC Plant Biology2005，23，：	1
17	Scanning electron microscopic analysis of diseased and healthy dental hard tissue after Er:YAG laser irradiation:in vitro study显示文摘	Armengol V Jean A Rohanizadeh R	1999	J Endod1999，25，8：	1
18	Role of alpha/beta interferons in the attenuation and immunogenicity of recombi nant bovine respiratory syncytial viruses lacking NS proteins显示文摘	Jean F V Julie F Sara W	2003	Virolology2003，77，15：	1
19	Constraints on the acquisition of remanent magnetization in fine-grained sediments imposed by redeposition experiments显示文摘	BRIAN C S JEAN P V MAXIME L G	2006	Earth and Planetary Science Letters2006，245，：	1
20	NOD2/CARD15 gene polymorphisms in Crohn’s disease: a genotype–phenotype analysis显示文摘	Denis Heresbach Véronique Gicquel-Douabin Brigitte Birebent Pierre-Nicolas D’halluin Nathalie Heresbach-Le Berre Stéphane Dreano Laurent Siproudhis Alain Dabadie Michel Gosselin Jean Mosser Gilbert Semana Jean-Fran?ois Bretagne Jacqueline Yaouanq	2004	European Journal of Gastroenterology & Hepatology2004，，1：	1

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