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| 1 | The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury显示文摘 | Tibor Kempf Matthias Eden Jens Strelau Marian Naguib Christian Willenbockel J?rn Tongers J?rg Heineke Daniel Kotlarz Jian Xu Jeffery D. Molkentin Hans W. Niessen Helmut Drexler Kai C. Wollert | 2006 | Circulation Research2006，，3： | 3 |
| 2 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 3 | Portal vein thrombosis after splenectomy显示文摘 | Emily R Winslow L.Michael Brunt Jeffery A Drebin Nathaniel J Soper Mary E Klingensmith | 2002 | The American Journal of Surgery2002，，6： | 3 |
| 4 | Pulmonary vascular remodeling: a target for therapeutic intervention in pulmonary hypertension显示文摘 | Wanstall J C | 2001 | Pharmacol Thera Peutics2001，92，： | 1 |
| 5 | Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection显示文摘 | Grimm PC Nickerson P Jeffery J | 2001 | N Engl J Med2001，345，2： | 1 |
| 6 | Elucidating the spread of the emerging canid nematode Angiostrongylus vasorum between Palaearctic and Nearctic ecozones显示文摘 | Jefferies R Shaw SE Willesen J et 01 | 2010 | Infect Genet Evol2010，10，4： | 1 |
| 7 | Plant pathogens and integrated defence responses to infection显示文摘 | JEFFERY L D JONATHAN D G J | 2001 | Nature2001，411，： | 1 |
| 8 | Dyeing paper with a new class of cationic colorants显示文摘 | Crounse P Jefferies P J Moore E K | 1975 | Tappi 11975，，： | 1 |
| 9 | Pulmonary vascular remodehng: a target for therapeutic intervention in pulmonary hypertension 显示文摘 | Jeffery T K Wanstall J C | 2001 | Pharmacol Ther2001，92，1： | 1 |
| 10 | Managemnent strategy impacts on ammonia volatilization from swine manure 显示文摘 | Daine M P Wendy J P Jeffery C L | 2005 | J Environ Qual2005，34，： | 1 |
| 11 | Early versus late enteral nu- tritional support in adults with burn injury显示文摘 | Wasiak J Cleland H Jeffery R | 2007 | J Hum Nutr Diet2007，20，2： | 1 |
| 12 | Oat germiuation characteristics differ among genotypes,seed sizes and osmotic potentials显示文摘 | CHRISTIAN J W JEFFERY C W ARON K M | 2005 | Crop Science2005，45，： | 1 |
| 13 | Evaluation of C-reactive protein, an inflammatory marker and infection serology as risk factors for coronary disease and myocardial infarction 显示文摘 | Jeffery L Anderson MD Face J F | 1998 | JAm Coll Cardiol1998，31，1： | 1 |
| 14 | Pulmonary vascular remodeling:a target for therapeutic intervention in pulmonary hypertension显示文摘 | JEFFERY T K WANSTALL J C | 2001 | Pharmacol Ther2001，92，： | 1 |
| 15 | A new method for the nonlinear transformation of means and covariances in filters and estimators显示文摘 | Simon J Jeffery U Hugh D | 2000 | IEEE Trans on Automatic Control2000，45，3： | 1 |
| 16 | Antioxidant capacity of different broccoli (brassica oleracea) genotypes using the oxygen radical absorbance capacity (ORAC) assay 显示文摘 | Kurilich A C Jeffery E H Juvik J A | 2002 | J Agric Food Chem2002，50，： | 1 |
| 17 | Perindopril, an angiotensin converting enzyme inhibitor, in pulmonary hypertensive rats: comparative effects on pulmonary vascular structure and function显示文摘 | Wanstall J C | 1999 | Br J Pharmacol1999，128，： | 1 |
| 18 | 查看详情显示文摘 | Chiefari J Chong Y.K Ercole F Krstina J. Jeffery J. Le T.P.T. Mayadunne R.T.A. Meijs G.F. Moad C.L. Moad G | | 0，，： | 1 |
| 19 | Pulmonary vascular remodeling in hypoxic rats: effects of amlodipine, alone and with perindopril显示文摘 | Wanstall J C | 2001 | Eur J Pharmacol2001，416，： | 1 |
| 20 | Corrosion protecting using-polyaniline coating formulations显示文摘 | Silvermau D C Jefferys C R | 1997 | Synthetic Metal1997，85，2： | 1 |
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