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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Factors predicting adverse short-term outcomes in patients with acute cholangitis undergoing ERCP: A single center experience显示文摘AIM: To identify potential factors that can predict adverse short-term outcomes in patients with acute cholangitis undergoing endoscopic retrograde cholangiopancreatography(ERCP). METHODS: Retrospective analysis of consecutive patients admitted to our center for acute cholangitis and underwent ERCP from 2001 to 2012. Involvement of two or more organ systems was termed as organ failure(OF). Cardiovascular failure was defined based on a systolic blood pressure of < 90 mmHg despite fluid replacement and/or requiring vasopressor treatment; respiratory failure if the Pa02 /Fi02 ratio was < 300 mmHg and/or required mechanical ventilation; coagulopathy if the platelet count was < 80; and renal insufficiency if serum creatinine was > 1.9 mg/dL. Variables associated with short term adverse clinical outcomes defined as persistent OF and/or 30-d mortality was determined. RESULTS: A total of 172 patients(median age 62 years, 56.4% female) were included. The median door to ERCP time was 17 h. Bile duct stones were the most common etiology(n = 67, 39.2%). In multivariate analysis, factors that were independently associated with persistent OF and/or 30-d mortality included American Society of Anesthesiology(ASA) physical classification score > 3(OR = 7.70; 95%CI: 2.73-24.40), presence of systemic inflammatory response syndrome(OR = 3.67; 95%CI: 1.34-10.3) and door to ERCP time greater than 72 h(OR = 3.36; 95%CI: 1.12-10.20). Door to ERCP time greater than 72 h was also associated with 70% increase in the mean length of stay(P < 0.001). Every one point increase in the ASA physical classification and every 1 mg/dL increase in the preERCP bilirubin level was associated with a 34% and 2% increase in the mean length of hospital stay, respectively. Transfer status did not impact clinical outcomes. CONCLUSION: Higher ASA physical classification and delays in ERCP are associated with adverse clinical outcomes and prolonged length of hospital stay in patients with acute cholangitis undergoing ERCP. | Udayakumar Navaneethan Norma G Gutierrez Ramprasad Jegadeesan Preethi GK Venkatesh Madhusudhan R Sanaka John J Vargo Mansour A Parsi | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
| 3 | Arsenate remediation using nanosized modified zerovalent iron particles显示文摘 | Jegadeesan G Mondal K Lalvani S B | 2005 | Environ Prog2005，24，： | 1 |
| 4 | Influence of trace metal distribution on its leachability from coal fly ash显示文摘 | JEGADEESAN G AL-ABED S R PINTO P | 2008 | Fuel2008，87，1011： | 1 |
| 5 | Leaching behavior of mineral processing waste: comparison of batch and column investigations显示文摘 | ALABED S R JEGADEESAN G PURANDARE J | 2008 | Journal of Hazardous Materials2008，153，3： | 1 |
| 6 | Comparative evaluation of short-term leach tests for heavy metal release from mineral processing waste 显示文摘 | Al-Abed S R Hageman P L Jegadeesan G | 2006 | Science of the Total Environment2006，364，13： | 1 |
| 7 | Estimation of bioactive principle, wedelolactone in Wedelia chinensis(Osbeck)Merr显示文摘 | Kamalam M Jegadeesan M | 1999 | Indian Drugs1999，36，7： | 1 |
| 8 | Topolog selection and efficiency improvement of inductive power links显示文摘 | JEGADEESAN R GUO Yongxin | 2012 | IEEE Transactions on Antennas and Propagation2012，60，10： | 1 |
| 9 | Comparative evaluation of short-term leach tests for heavy metal release from mineral processing waste显示文摘 | Al-Abed S R Hageman P L Jegadeesan G | 2006 | Science of the Total Environment2006，364，13： | 1 |
| 10 | Arsenate remediation using nanosized modified zerovalent iron particles显示文摘 | JEGADEESAN G MONDAL K LALVANI S B | 2005 | Environmental Progress2005，24，3： | 1 |
| 11 | Anti-diabetic activity of alcoholic extract of Celosia argentea seeds in rats显示文摘 | Vetrichelvan T Jegadeesan M Devi B A U | 2002 | Biological and Pharmaceutical Bulletin2002，25，4： | 1 |
| 12 | Comparative evaluation of short-term leach tests for heavy metal release from mineral processing waste显示文摘 | A1-Abed S R Hageman P L Jegadeesan G | 2006 | Science of the Total Environment2006，364，： | 1 |
| 13 | Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis显示文摘 | Udayakumar Navaneethan Norma G. Gutierrez Ramprasad Jegadeesan Preethi G.K. Venkatesh Mujtaba Butt Madhusudhan R. Sanaka John J. Vargo Mansour A. Parsi | 2013 | Gastrointestinal Endoscopy2013，，1： | 1 |
| 14 | Selenate removal from sulfate containing aqueous solutions 显示文摘 | JEGADEESAN G MONDAL K LALVANI S B | 2005 | Environ Technol2005，26，： | 1 |
| 15 | Impact of Concurrent Non-IBD ImmunologicalDiseases on the Outcome of Primary SclerosingCholangitis显示文摘 | Jegadeesan R Navaneethan U Bharadwaj S | 2016 | Inflamm Bowel Dis2016，22，4： | 1 |
| 16 | Arsenic release from iron rich mineral processing waste:Influence of pH and redox potential 显示文摘 | Al-Abed S R Jegadeesan G Purandare J | 2007 | Chemosphere2007，66，4： | 1 |
| 17 | Molecular analysis of glyci- nin genes in soybean mutants for development of gene-specific markers 显示文摘 | Jegadeesan S Yu K Woodrow L | 2012 | Theoretical and Applied Genetics2012，124，： | 1 |
| 18 | Comparative evaluation of short-term leach tests for heavy metal release from mineral processing waste显示文摘 | Al-Abed S R Hageman P L Jegadeesan G | 2006 | Science of The Total Environment2006，364，13： | 1 |
| 19 | Delay in performing ERCP and adverse events increase the 30-day readmission risk in patients with acute cholangitis显示文摘 | Navaneethan U Gutierrez NG Jegadeesan R | 2013 | Gastrointest Endosc2013，78，： | 1 |
| 20 | Influence of trace metal distribution on its leachability from coal fly ash 显示文摘 | Jegadeesan G A1-Abed S R Pinto P | 2008 | Fuel2008，87，10： | 1 |
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