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| 1 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 2 | Cross-cultural Pragmatic Failure显示文摘 | JENNY T | 1983 | Applied Linguistics41983，，2： | 1 |
| 3 | Caffeic acid and glycerol are constituents of the suberin layers in green cotton fibers显示文摘 | Schmutz A Jenny T Amrhein N | 1993 | Planta1993，189，3： | 1 |
| 4 | Pregnancy after endometrial ablation:English literature review and case report显示文摘 | Jenny SY Mrcog T Andrew P | 2006 | J Minimally Invasive Gynecol2006，13，2： | 1 |
| 5 | Diego interacts with Prickle and Stra-bismus/Van Gogh to localize planar cell polarity complexes显示文摘 | Das G Jenny A Klein T | 2004 | Deve-lopment2004，131，： | 1 |
| 6 | Comparative study of decomposition rates of organic matter in temperate and tropical regions显示文摘 | Jenny H Gesel S P Bingham F T | 1989 | Soil Sci1989，68，： | 1 |
| 7 | Determination of size and concentration of gold nanoparticles from UV-vis spectra显示文摘 | Wolfgang H Nguyen T K T Jenny A | 2007 | Analytical Chemistry2007，79，11： | 1 |
| 8 | Congenital coronary artery fistulas in children and adults:diagnosis,surgical tech-nique and results显示文摘 | Carrel T Tkebuchava T Jenni R | | 0，，： | 1 |
| 9 | Gradual soil water depletion results in reversible changes of gene expression,protein profiles,ecophysiology,and growth performance in Populus euphratica,a poplar growing in arid regions1显示文摘 | MARIE-BéATRICE B T MIKAEL B JENNY R | 2007 | Plant Physiology2007，143，： | 1 |
| 10 | Incidence, clinical aspects and therapy of late pericardial tamponade following heart surgery显示文摘 | Wilhelm M Carrel T Jenni R | 1996 | Swiss Surg1996，3，： | 1 |
| 11 | Thermal and flammability properties of polypropylene/carbon nanotube nanocomposites显示文摘 | Kashiwagi T Grulke Eric A Jenny Hilding | 2004 | Polymer2004，45，12： | 1 |
| 12 | Modifying In- terpretation in a Clinically Depressed Sample Using Cog- nitive Bias Modification-Errors': A Double Blind Random- ized Controlled Trial 显示文摘 | JENNY Y JONG S L SINEM T | 2014 | Cognitive Therapy and Re- search2014，38，2： | 1 |
| 13 | Calcium pyrophosphate dihydrate crystal deposition disease显示文摘 | Jenny T Bencardino Alvand | 2003 | Semin Musculoskelet Radiol2003，7，2： | 1 |
| 14 | Pregnancy after endometrial ablation:English literature riview and case report显示文摘 | Jenny SY Mrcong T Andrew P | 2006 | J Minimally Invasive Gynecol2006，13，2： | 1 |
| 15 | Incidence,clinical aspects and therapy of late pericardial tamponade following heart surgery显示文摘 | Carrel T Jenni R | 1996 | Swiss Surg1996，3，： | 1 |
| 16 | Wagner Successful extracorporeal life support using a new micro-diagonal pump in a child with acute laryngotra - cheobronchitis, lung failure, and untractable septic shock 显示文摘 | Carrel T Gygax E Jenni H | 2007 | Journal of Thoracic and Cardiovascular Surgery2007，133，3： | 1 |
| 17 | On--line learning control by association and reinforcement 显示文摘 | Jennie S Wang Y T | 2001 | IEEE Transactions on Neural Networks2001，12，2： | 1 |
| 18 | Localized expression of the seizure-related gene SEZ-6 in developing and adult forebrains显示文摘 | Mary HK Jenny MG Seong-Seng T | 2002 | Mech Dev2002，118，12： | 1 |
| 19 | Prediction of stiffness and damping coefficients for centrifugal compressor labyrinth seals 显示文摘 | WYSSMANN H PHAM T JENNY R | 1984 | ASME J of Engineering for Gas Turbines and Power1984，106，4： | 1 |
| 20 | Congenital coronary artery fistulas inchildren and adults:diagnosis,surgical technique and results显示文摘 | Carrel T Tkebuchava T Jenni R | 1996 | Cardiology1996，87，： | 1 |
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