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| 1 | The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury显示文摘 | Tibor Kempf Matthias Eden Jens Strelau Marian Naguib Christian Willenbockel J?rn Tongers J?rg Heineke Daniel Kotlarz Jian Xu Jeffery D. Molkentin Hans W. Niessen Helmut Drexler Kai C. Wollert | 2006 | Circulation Research2006,,3: | 3 |
| 2 | Best supportive care (BSC) versus oxaliplatin, folinic acid and 5-fluorouracil (OFF) plus BSC in patients for second-line advanced pancreatic cancer: A phase III-study from the German CONKO-study group显示文摘 | Uwe Pelzer Ingo Schwaner Jens Stieler Mathias Adler J?rg Seraphin Bernd D?rken Hanno Riess Helmut Oettle | 2011 | European Journal of Cancer2011,,11: | 2 |
| 3 | Acute plasticity in the human somatosensory cortex following amputation 显示文摘 | Borsook d Beeerra L Fishman S Edwards A Jennings CL Stojanovic M Papinicolas L Ramachandran VS Gonzalez RG Breiter H | 1998 | Neuroreport1998,9,6: | 1 |
| 4 | Dynamic changes in O-GlcNAcylation regulate osteoclast differentiation and bone loss via nucleoporin 153显示文摘Bone mass is maintained by the balance between osteoclast-induced bone resorption and osteoblast-triggered bone formation.In inflammatory arthritis such as rheumatoid arthritis(RA),however,increased osteoclast differentiation and activity skew this balance resulting in progressive bone loss.O-GlcNAcylation is a posttranslational modification with attachment of a single O-linkedβ-D-N-acetylglucosamine(O-GlcNAc)residue to serine or threonine residues of target proteins.Although O-GlcNAcylation is one of the most common protein modifications,its role in bone homeostasis has not been systematically investigated.We demonstrate that dynamic changes in O-GlcNAcylation are required for osteoclastogenesis.Increased O-GlcNAcylation promotes osteoclast differentiation during the early stages,whereas its downregulation is required for osteoclast maturation.At the molecular level,O-GlcNAcylation affects several pathways including oxidative phosphorylation and cell-cell fusion.TNFαfosters the dynamic regulation of O-GlcNAcylation to promote osteoclastogenesis in inflammatory arthritis.Targeted pharmaceutical or genetic inhibition of O-GlcNAc transferase(OGT)or O-GlcNAcase(OGA)arrests osteoclast differentiation during early stages of differentiation and during later maturation,respectively,and ameliorates bone loss in experimental arthritis.Knockdown of NUP153,an O-GlcNAcylation target,has similar effects as OGT inhibition and inhibits osteoclastogenesis.These findings highlight an important role of O-GlcNAcylation in osteoclastogenesis and may offer the potential to therapeutically interfere with pathologic bone resorption. | Yi-Nan Li Chih-Wei Chen Thuong Trinh-Minh Honglin Zhu Alexandru-Emil Matei Andrea-Hermina Györfi Frederic Kuwert Philipp Hubel Xiao Ding Cuong Tran Manh Xiaohan Xu Christoph Liebel Vladyslav Fedorchenko Ruifang Liang Kaiyue Huang Jens Pfannstiel Min-Chuan Huang Neng-Yu Lin Andreas Ramming Georg Schett Jörg H.W.Distler | 2022 | Bone Research2022,10,4: | 1 |
| 5 | Diabetes and arterialextracellular matrix changes in a porcine model of atherosclerosis显示文摘 | McDonald TO Gerrity RG Jen C | 2007 | Histochem Cytochem2007,55,11: | 1 |
| 6 | Structural interpretation of mutations in phenylalanine hydroxylase protein aidsin identifying genotype-phenotype correlations in phenylketonuria 显示文摘 | Jennings IG Cotton RG Kobe B | 2000 | Eur J Hum Genet2000,8,9: | 1 |
| 7 | Mandibular third molar removal: Risk indicators for extended operation time, postoperative pain, and complications显示文摘 | Ingibj?rg S Benediktsdóttir Ann Wenzel Jens K Petersen Hanne Hintze | 2004 | Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology2004,,4: | 1 |
| 8 | Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function显示文摘 | Dickson PW Jennings IG Cotton RG | | 0,,32: | 1 |
| 9 | Transapical minimally invasive aortic valve implantation; the initial 50 patients显示文摘 | Thomas Walther Volkmar Falk J?rg Kempfert Michael A. Borger Jens Fassl Michael W.A. Chu Gerhard Schuler Friedrich W. Mohr | 2008 | European Journal of Cardio-Thoracic Surgery2008,,6: | 1 |
| 10 | New Design for QCM Sensors in Liquids显示文摘 | J? rg Auge Peter Hauptmann Jens Hartmann | 1995 | Sensors and Actuators B1995,2425,: | 1 |
| 11 | Diabetes and arterial extracellular matrix changes in a porcine model of atherosclerosis显示文摘 | McDonald TO Gerrity RG Jen C | | 0,,: | 1 |
| 12 | Subsynchronous resonanceof a power station with two identical generating units 显示文摘 | Jennings G D Harley RG Levy DC | 1986 | IEEProceedings of Generation Transmission and Distribution1986,133,1: | 1 |
| 13 | The all-diode-pumped laser system POLARIS——an experimentalist's tool generating ultra-high contrast pulses with high energy显示文摘The development,the underlying technology and the current status of the fully diode-pumped solid-state laser system POLARIS is reviewed.Currently,the POLARIS system delivers 4 J energy,144 fs long laser pulses with an ultra-high temporal contrast of 5 × 1012 for the ASE,which is achieved using a so-called double chirped-pulse amplification scheme and cross-polarized wave generation pulse cleaning.By tightly focusing,the peak intensity exceeds 3.5 × 1020 W cm-2.These parameters predestine POLARIS as a scientific tool well suited for sophisticated experiments,as exemplified by presenting measurements of accelerated proton energies.Recently,an additional amplifier has been added to the laser chain.In the ramp-up phase,pulses from this amplifier are not yet compressed and have not yet reached the anticipated energy.Nevertheless,an output energy of 16.6 J has been achieved so far. | Marco Hornung Hartmut Liebetrau Andreas Seidel Sebastian Keppler Alexander Kessler Jrg Krner Marco Hellwing Frank Schorcht Diethard Klpfel Ajay K.Arunachalam Georg A.Becker Alexander Svert Jens Polz Joachim Hein Malte C.Kaluza | 2014 | High Power Laser Science and Engineering2014,2,3: | 1 |
| 14 | Resection of the intrapancreatic bile duct preserving the pancreas显示文摘 | Armin Kolb J?rg Kleeff Boris Frohlich Jens Werner Helmut Friess Markus W. Büchler | 2009 | Journal of Hepato-Biliary-Pancreatic Surgery2009,,1: | 1 |
| 15 | Cannabinoids Acting on CB1 Receptors Decrease Contractile Performance in Human Atrial Muscle显示文摘 | Andreas Bonz Martin Laser Sina Küllmer Silke Kniesch J?rg Babin-Ebell Verena Popp Georg Ertl Jens Andreas Wagner | 2003 | Journal of Cardiovascular Pharmacology2003,,4: | 1 |
| 16 | Laparoscopic repair of perforated gastroduodenal ulcer by running suture显示文摘 | J?rg K?ninger Peter B?ttinger Jens Redecke Michael Butters | 2004 | Langenbeck’s Archives of Surgery2004,,1: | 1 |
| 17 | Natural DNA variation at candidate loci is associated with potato chip color, tuber starch content, yield and starch yield显示文摘 | Li Li Maria-Jo?o Paulo Josef Strahwald Jens Lübeck Hans-Reinhard Hofferbert Eckhart Tacke Holger Junghans J?rg Wunder Astrid Draffehn Fred Eeuwijk Christiane Gebhardt | | 0,,: | 1 |
| 18 | Management of bowel obstruetionin patients with abdominal cancer 显示文摘 | Woolfson RG Jennings K Whalen GF | 1997 | ArchSurg1997,132,: | 1 |
| 19 | The Temperature Response of CO2 Production from Bulk Soils and Soil Fractions is Related to Soil Organic Matter Quality显示文摘 | Jens Leifeld Jürg Fuhrer | 2005 | Biogeochemistry2005,,3: | 1 |
| 20 | Analytical and simulative performance evaluation of cluster-based multihop ad hoc networks显示文摘 | J?rg Habetha Jens Wiegert | 2003 | Journal of Parallel and Distributed Computing2003,,2: | 1 |