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| 1 | Upper gastrointestinal sensory-motor dysfunction in diabetes mellitus显示文摘胃肠(官方补给) 感觉马达的畸形在有糖尿病的病人是普通的并且可以包含官方补给的道的任何部分。畸形经常是无临床症状的,并且幸好,严重、威胁生活的问题仅仅很少发生。在糖尿病的反常上面的官方补给的感觉马达的功能的致病不完全地被理解并且是最可能的起源多因素。糖尿病的自治神经病以及糖尿病的尖锐非最优的控制被显示了损害官方补给的马达和感觉功能。词法并且官方补给的墙的机械改变在糖尿病的持续时间期间开发的简历,并且可以贡献马达和感觉机能障碍。在感觉的这评论和活动性,在糖尿病的上面的官方补给的道的混乱被讨论;并且与感觉马达的机能障碍有关的机械改变也是的词法变化和简历探讨了。 | Jingbo Zhao Jens Brφndum Frφkjaer Asbjφrn Mohr Drewes Niels Ejskjaer | 2006 | World Journal of Gastroenterology2006，12，18： | 15 |
| 2 | Impaired contractility and remodeling of the upper gastrointestinal tract in diabetes mellitus type-1显示文摘AIM: To investigate that both the neuronal function of the contractile system and structural apparatus of the gastrointestinal tract are affected in patients with longstanding diabetes and auto mic neuropathy. METHODS: The evoked esophageal and duodenal contractile activity to standardized bag distension was assessed using a specialized ultrasound-based probe. Twelve type-1 diabetic patients with autonomic neuropathy and severe gastrointestinal symptoms and 12 healthy controls were studied. The geometry and biomechanical parameters (strain, tension/stress, and stiffness) were assessed. RESULTS: The diabetic patients had increased frequency of distension-induced contractions (6.0 ± 0.6 vs 3.3 ± 0.5, P < 0.001). This increased reactivity was correlated with the duration of the disease (P = 0.009). Impaired coordination of the contractile activity in diabetic patients was demonstrated as imbalance between the time required to evoke the first contraction at the distension site and proximal to it (1.5 ± 0.6 vs 0.5 ± 0.1, P = 0.03). The esophageal wall and especially the mucosa-submucosa layer had increased thickness in the patients (P < 0.001), and the longitudinal and radial compressive stretch was less in diabetics (P <0.001). The esophageal and duodenal wall stiffness and circumferential deformation induced by the distensions were not affected in the patients (all P > 0.14). CONCLUSION: The impaired contractile activity with an imbalance in the distension-induced contractions likely reflects neuronal abnormalities due to autonomic neuropathy. However, structural changes and remodeling of the gastrointestinal tract are also evident and may add to the neuronal changes. This may contribute to the pathophysiology of diabetic gut dysfunction and impact on future management of diabetic patients with gastrointestinal symptoms. | Jens BrΦndum FrΦkjΦr SΦren Due Andersen Niels EjskjΦr Peter Funch-Jensen AsbjΦrn Mohr Drewes Hans Gregersen | 2007 | World Journal of Gastroenterology2007，13，36： | 8 |
| 3 | 糖尿病性上消化道感觉和运动功能异常显示文摘糖尿病患者胃肠感觉运动功能异常非常常见,其可涉及胃肠道各个部位。糖尿病性胃肠异常经常是亚临床的,庆幸的是罕有严重和危及生命的问题发生。人们尚未完全了解糖尿病性上消化道感觉运动功能异常的发病机制,但是其机制似乎是多源性的。研究表明,糖尿病性自主神经病变和急性血糖异常可损伤感觉运动功能。糖尿病发展过程中胃肠道结构和生物力学特性的重构也可能与感觉运动功能异常有关。本综述只讨论糖尿病性上消化道感觉运动功能异常,同时结合讨论胃肠道结构和生物力学特性的重构在糖尿病性上消化道感觉运动功能异常发展中的作用。 | 赵静波 Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Niels Ejskjaer | 2008 | 医学综述2008，14，23： | 6 |
| 4 | Pain and chronic pancreatitis: A complex interplay of multiple mechanisms显示文摘Despite multiple theories on the pathogenesis of pain in chronic pancreatitis,no uniform and consistently successful treatment strategy exists and abdominal pain still remains the dominating symptom for most patients and a major challenge for clinicians.Traditional theories focussed on a mechanical cause of pain related to anatomical changes and evidence of increased ductal and interstitial pressures.These observations form the basis for surgical and endoscopic drainage procedures,but the outcome is variable and often unsatisfactory.This underscores the fact that other factors must contribute to pathogenesis of pain,and has shifted the focus towards a more complex neurobiological understanding of pain generation.Amongst other explanations for pain,experimental and human studies have provided evidence that pain perception at the peripheral level and central pain processing of the nociceptive information is altered in patients with chronic pancreatitis,and resembles that seen in neuropathic and chronic pain disorders.However,pain due to e.g.,complications to the disease and adverse effects to treatment must not be overlooked as an additional source of pain.This review outlines the current theories on pain generation in chronic pancreatitis which is crucial in order to understand the complexity and limitations of current therapeutic approaches.Furthermore,it may also serve as an inspiration for further research and development of methods that can evaluate the relative contribution and interplay of different pain mechanisms in the individual patients,before they are subjected to more or less empirical treatment. | Jakob Lykke Poulsen Sφren Schou Olesen Lasse Paludan Malver Jens Brφndum Frφkjr Asbjφrn Mohr Drewes | 2013 | World Journal of Gastroenterology2013，19，42： | 5 |
| 5 | Brain changes in diabetes mellitus patients withgastrointestinal symptoms显示文摘Diabetes mellitus is a common disease and its prevalence is increasing worldwide. In various studies up to 30%-70% of patients present dysfunction and complications related to the gut. To date several clinical studies have demonstrated that autonomic nervous system neuropathy and generalized neuropathy of the central nervous system(CNS) may play a major role. This systematic review provides an overview of the neurodegenerative changes that occur as a consequence of diabetes with a focus on the CNS changes and gastrointestinal(GI) dysfunction. Animal models where diabetes was induced experimentally support that the disease induces changes in CNS. Recent investigations with electroencephalography and functional brain imaging in patients with diabetes confirm these structural and functional brain changes. Encephalographic studies demonstrated that altered insular processing of sensory stimuli seems to be a key player in symptom generation. In fact one study indicated that the more GI symptoms the patients experienced, the deeper the insular electrical source was located. The electroencephalography was often used in combination with quantitative sensory testingmainly showing hyposensitivity to stimulation of GI organs. Imaging studies on patients with diabetes and GI symptoms mainly showed microstructural changes,especially in brain areas involved in visceral sensory processing. As the electrophysiological and imaging changes were associated with GI and autonomic symptoms they may represent a future therapeutic target for treating diabetics either pharmacologically or with neuromodulation. | Anne M Drewes Eirik Søfteland Georg Dimcevski Adam D Farmer Christina Brock Jens B Frøkjær Klaus Krogh Asbjørn M Drewes | 2016 | World Journal of Diabetes2016，7，2： | 4 |
| 6 | The Transforming Growth Factor-β Superfamily Member Growth-Differentiation Factor-15 Protects the Heart From Ischemia/Reperfusion Injury显示文摘 | Tibor Kempf Matthias Eden Jens Strelau Marian Naguib Christian Willenbockel J?rn Tongers J?rg Heineke Daniel Kotlarz Jian Xu Jeffery D. Molkentin Hans W. Niessen Helmut Drexler Kai C. Wollert | 2006 | Circulation Research2006，，3： | 3 |
| 7 | Adding pegylated interferon to a current nucleos(t)ide therapy leads to HBsAg seroconversion in a subgroup of patients with chronic hepatitis B显示文摘 | Jens M. Kittner Martin F. Sprinzl Annette Grambihler Arndt Weinmann J?rn M. Schattenberg Peter R. Galle Marcus Schuchmann | 2012 | Journal of Clinical Virology2012，，1： | 2 |
| 8 | Postoperative Neurocognitive Dysfunction in Elderly Patients after Xenon versus Propofol Anesthesia for Major Noncardiac Surgery: A Double-blinded Randomized Controlled Pilot Study显示文摘 | Jan H?cker Claudia Stapelfeldt J?rn Leiendecker Patrick Meybohm Robert Hanss Jens Scholz Berthold Bein | 2009 | Anesthesiology2009，，5： | 2 |
| 9 | Imaging of the gastrointestinal tract-novel technologies显示文摘Imaging of the gastrointestinal tract is very useful for research and clinical studies of patients with symptoms arising from the gastrointestinal tract and in visualising anatomy and pathology. Traditional radiological techniques played a leading role in such studies for a long time. However, advances in non-invasive modalities including ultrasound (US), computed tomography (CT), positron emission tomography (PET), magnetic resonance imaging (MRI), etc, have in the last decades revolutionised the way in which the gastrointestinal tract is studied. The resolution of imaging data is constantly being improved and 3D acquisition, tools for fi ltering, enhancement, segmentation and tissue classif ication are continually being developed. Additional co-registration techniques allow multimodal data acquisition with improved classif ication of tissue pathology. Furthermore, new functional imaging techniques have become available. Altogether, the future of gastrointestinal imaging looks very promising which will be of great benef it in clinical and research studies of gastrointestinal diseases. The purpose of this review is to highlight the capabilities of the newest techniques to explore the detailed morphology, biomechanical properties, function and pathology of the gastrointestinal tract. | Jens Brφndum Frφkjr Asbjφrn Mohr Drewes Hans Gregersen | 2009 | World Journal of Gastroenterology2009，15，2： | 2 |
| 10 | Resveratrol in metabolic health: an overview of the current evidence and perspectives显示文摘 | Morten M?ller Poulsen Jens Otto Lunde J?rgensen Niels Jessen Bj?rn Richelsen Steen B?nl?kke Pedersen | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 11 | Translational aspects of rectal evoked potentials: a comparative study in rats and humans显示文摘 | Thomas Dahl Nissen Christina Brock Carina Graversen Steven J. Coen Leif Hultin Qasim Aziz Jens Lykkesfeldt Asbj?rn Mohr Drewes | 2013 | AJP: Gastrointestinal and Liver Physiology2013，，2： | 1 |
| 12 | Elucidation of the origin of multiple conformations of the human α3-chain type VI collagen C-terminal Kunitz domain: The reorientation of the Trp21 ring显示文摘 | Morten Dahl S?rensen S?ren M. Kristensen S?ren Bj?rn Kjeld Norris Ole Olsen Jens J. Led | 1996 | Journal of Biomolecular NMR1996，，4： | 1 |
| 13 | Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes显示文摘 | Monique Gannagé Dorothee Dormann Randy Albrecht J?rn Dengjel Tania Torossi Patrick C. R?mer Monica Lee Till Strowig Frida Arrey Gina Conenello Marc Pypaert Jens Andersen Adolfo García-Sastre Christian Münz | 2009 | Cell Host & Microbe2009，，4： | 1 |
| 14 | Matrix Protein 2 of Influenza A Virus Blocks Autophagosome Fusion with Lysosomes显示文摘 | Monique Gannagé Dorothee Dormann Randy Albrecht J?rn Dengjel Tania Torossi Patrick C. R?mer Monica Lee Till Strowig Frida Arrey Gina Conenello Marc Pypaert Jens Andersen Adolfo García-Sastre Christian Münz | 2009 | Cell Host & Microbe2009，，4： | 1 |
| 15 | Indications for and Outcomes After Combined Lung and Liver Transplantation: A Single-Center Experience on 13 Consecutive Cases显示文摘 | Gerrit Grannas Michael Neipp Marius M. Hoeper Jens Gottlieb Rainer Lück Thomas Becker Andre Simon Christian P. Strassburg Michael P. Manns Tobias Welte Axel Haverich Jürgen Klempnauer Bj?rn Nashan Martin Strueber | 2008 | Transplantation2008，，4： | 1 |
| 16 | Opioid-Induced Bowel Dysfunction显示文摘 | Christina Brock S?ren Schou Olesen Anne Estrup Olesen Jens Br?ndum Fr?kjaer Trine Andresen Asbj?rn Mohr Drewes | 2012 | Drugs2012，，14： | 1 |
| 17 | Climate change impacts on groundwater and dependent ecosystems显示文摘 | Bj?rn Kl?ve Pertti Ala-Aho Guillaume Bertrand Jason J. Gurdak Hans Kupfersberger Jens Kv?rner Timo Muotka Heikki Mykr? Elena Preda Pekka Rossi Cintia Bertacchi Uvo Elzie Velasco Manuel Pulido-Velázquez | 2013 | Journal of Hydrology2013，，： | 1 |
| 18 | Resveratrol has inhibitory effects on the hypoxia-induced inflammation and angiogenesis in human adipose tissue in vitro显示文摘 | Karina B. Cullberg Jens Olholm S?ren K. Paulsen Casper B. Foldager Martin Lind Bj?rn Richelsen Steen B. Pedersen | 2013 | European Journal of Pharmaceutical Sciences2013，，2： | 1 |
| 19 | Gastrointestinal sensitivity and gastroesophageal reflux disease显示文摘 | Annamaria Altomare Michele Pier Luca Guarino (Sara Emerenziani) Michele Cicala Asbj?rn Mohr Drewes Anne Lund Krarup Christina Brock Christian Lottrup Jens Br?ndum Fr?kj?r Rhonda F. Souza Gerardo Nardone Debora Compare | 2013 | Ann NY Acad Sci2013，，1： | 1 |
| 20 | Update of exocrine functional diagnostics in chronic pancreatitis显示文摘 | Camilla N?jgaard S?ren Schou Olesen Jens Br?ndum Fr?kj?r Asbj?rn Mohr Drewes | 2013 | Clin Physiol Funct Imaging2013，，3： | 1 |
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