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| 1 | Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells显示文摘AIM:To investigate the anti-inflammatory effects of cinnamon extract and elucidate its mechanisms for targeting the function of antigen presenting cells.METHODS:Cinnamon extract was used to treat murine macrophage cell line(Raw 264.7),mouse primary antigen-presenting cells(APCs,MHCII+) and CD11c+dendritic cells to analyze the effects of cinnamon extract on APC function.The mechanisms of action of cinnamon extract on APCs were investigated by analyzing cytokine production,and expression of MHC antigens and co-stimulatory molecules by quantitative real-time PCR and flow cytometry.In addition,the effect of cinnamon extract on antigen presentation capacity and APC-dependent T-cell differentiation were analyzed by [H3]-thymidine incorporation and cytokine analysis,respectively.To confirm the anti-inflammatory effects of cinnamon extract in vivo,cinnamon or PBS was orally administered to mice for 20 d followed by induction of experimental colitis with 2,4,6 trinitrobenzenesulfonic acid.The protective effects of cinnamon extract against experimental colitis were measured by checking clinical symptoms,histological analysis and cytokine expression prof iles in inflamed tissue.RESULTS:Treatment with cinnamon extract inhibited maturation of MHCII+ APCs or CD11c+ dendritic cells(DCs) by suppressing expression of co-stimulatory molecules(B7.1,B7.2,ICOS-L),MHCII and cyclooxygenase(COX)-2.Cinnamon extract induced regulatory DCs(rDCs) that produce low levels of pro-inflammatory cytokines [interleukin(IL)-1β,IL-6,IL-12,interferon(IFN)-γ and tumor necrosis factor(TNF)-α] while expressing high levels of immunoregulatory cytokines(IL-10 and transforming growth factor-β).In addition,rDCs generated by cinnamon extract inhibited APC-dependent T-cell proliferation,and converted CD4+ T cells into IL-10high CD4+ T cells.Furthermore,oral administration of cinnamon extract inhibited development and progression of intestinal colitis by inhibiting expression of COX-2 and pro-inflammatory cytokines(IL-1β,IFN-γ and TNF-α),while enhancing IL-10 levels.CONCLUSION:Our study suggests the potential of cinnamon extract as an anti-inflammatory agent by targeting the generation of regulatory APCs and IL-10+ regulatory T cells. | Ho-Keun Kwon Ji-Sun Hwang Choong-Gu Lee Jae-Seon So Anupama Sahoo Chang-Rok Im Won Kyung Jeon Byoung Seob Ko Sung Haeng Lee Zee Yong Park Sin-Hyeog Im | 2011 | World Journal of Gastroenterology2011，17，8： | 6 |
| 2 | Human mesenchymal stem cells derived from umbilical cord and bone marrow exert immunomodulatory effects in different mechanisms显示文摘BACKGROUND Mesenchymal stem cells(MSCs)are an attractive tool to treat graft-versus-host disease because of their unique immunoregulatory properties.Although human bone marrow-derived MSCs(BM-MSCs)were the most widely used MSCs in cell therapy until recently,MSCs derived from human umbilical cords(UC-MSCs)have gained popularity as cell therapy material for their ethical and noninvasive collection.AIM To investigate the difference in mechanisms of the immunosuppressive effects of UC-MSCs and BM-MSCs.METHODS To analyze soluble factors expressed by MSCs,such as indolamine 2,3-dioxygenase,cyclooxygenase-2,prostaglandin E2 and interleukin(IL)-6,inflammatory environments in vitro were reconstituted with combinations of interferon-gamma(IFN-γ),tumor necrosis factor alpha and IL-1βor with IFN-γalone.Activated T cells were cocultured with MSCs treated with indomethacin and/or anti-IL-10.To assess the ability of MSCs to inhibit T helper 17 cells and induce regulatory T cells,induced T helper 17 cells were cocultured with MSCs treated with indomethacin or anti-IL-10.Xenogeneic graft-versus-host disease was induced in NOG mice(NOD/Shi-scid/IL-2Rγnull)and UC-MSCs or BM-MSCs were treated as cell therapies.RESULTS Our data demonstrated that BM-MSCs and UC-MSCs shared similar phenotypic characteristics and immunomodulation abilities.BM-MSCs expressed more indolamine 2,3-dioxygenase after cytokine stimulation with different combinations of IFN-γ,tumor necrosis factor alpha-αand IL-1βor IFN-γalone.UC-MSCs expressed more prostaglandin E2,IL-6,programmed death-ligand 1 and 2 in the in vitro inflammatory environment.Cyclooxygenase-2 and IL-10 were key factors in the immunomodulatory mechanisms of both MSCs.In addition,UC-MSCs inhibited more T helper 17 cells and induced more regulatory T cells than BM-MSCs.UC-MSCs and BM-MSCs exhibited similar effects on attenuating graft-versus-host disease.CONCLUSION UC-MSCs and BM-MSCs exert similar immunosuppressive effects with different mechanisms involved.These findings suggest that UC-MSCs have distinct immunoregulatory functions and may substitute BM-MBSCs in the field of cell therapy. | Yunejin Song Jung-Yeon Lim Taekyu Lim Keon-Il Im Nayoun Kim Young-Sun Nam Young-Woo Jeon Jong Chul Shin Hyun Sun Ko In Yang Park Seok-Goo Cho | 2020 | World Journal of Stem Cells2020，12，9： | 4 |
| 3 | Novel molecular drug carrier:Encapsulation of oxaliplatin in cucurbit uril and its effects on stability and reactivity of the drug显示文摘 | JEON Y J KIM S Y KO Y H | 2005 | Org Biomol Chem2005，3，11： | 1 |
| 4 | Assessment of global left ventricular function with dual-source computed tomography in patients with valvular heart disease显示文摘 | Bak SH Ko SM Jeon HJ | 2012 | Acta Radiol2012，53，3： | 1 |
| 5 | Digital image stabilizing algorithms based on bit-plane matching 显示文摘 | KO S J LEE S H JEON S W | 1998 | IEEE Transactions on Consumer Electronics1998，44，3： | 1 |
| 6 | Preparation and application of an oil soluble Co-Mo bimetallic catalyst for the hydrocrac- king of oil sands bitumen显示文摘 | Jeon S G Na J G Ko C H | 2011 | Energy & Fuels2011，25，10： | 1 |
| 7 | A new approach for prepara- tion of oil-soluble bimetallic dispersed catalyst from layered ammonium nickel molybdate显示文摘 | Jeon S G Na J G Ko C H et ai | 2011 | Materials Science and Engi neering: B2011，176，7： | 1 |
| 8 | Fast Digital Image Stabi- lizer Based on Gray-coded Bit-plane Matching 显示文摘 | Ko S Lee S Jeon S | 1999 | IEEE Transaction on Consumer Electronics1999，45，3： | 1 |
| 9 | Balanced Topologyto Cancel Tx Leakage in CW Radar显示文摘 | KIM J G KO S JEON S | 2004 | IEEE Micro-wave and Wireless Components Letters2004，14，9： | 1 |
| 10 | Protective effect of curcumin in rat liver injury induced by carbon tetrachloride显示文摘 | Park EJ Jeon CH Ko G | 2000 | J Pharm Pharmacol2000，52，4： | 1 |
| 11 | Characterization of Bi-TiO2 nanometer sized particle synthesized by solvothermal method and CH3CHO decomposition in a plasma-photocatalytic system显示文摘 | Misook Kang Yu-Ri Ko Min-Kyu Jeon | 2005 | IEEE2005，2，： | 1 |
| 12 | Fast digital image stabilizer based on gray-coded bit-plane matching显示文摘 | Ko S Lee S Jeon S | 1999 | IEEE Transactions on Consumer Electronics1999，45，： | 1 |
| 13 | Effects of the composition of sputtering target on the stability of InGaZnO thin film transistor显示文摘 | Jun-Young Huh Jae-Hong Jeon Hee-Hwan Choe Kang-Woong Lee Jong-Huyn Seo Min-Ki Ryu Sang-Hee Ko Park Chi-Sun Hwang Woo-Seok Cheong | 2011 | Thin Solid Films2011，，20： | 1 |
| 14 | AZO/Au/AZO multilayer as atransparent conductive electrode 显示文摘 | LEE S BANG S PARK J PARK S KO Y JEON H | 2012 | Physica Status Solidi A-Applications and Materials Science2012，209，： | 1 |
| 15 | Prevalence of diabetes and prediabe- tes according to fasting plasma glucose and HbAlc 显示文摘 | Jeon JY Ko SH Kwon HS | 2013 | Diabetes Metab J2013，37，37： | 1 |
| 16 | Fast digital image stabilizer based on gray-coded bit-plane matching 显示文摘 | Ko S Lee S Jeon S Kang E | 1999 | IEEE Transactions on Consumer Electronics1999，45，3： | 1 |
| 17 | Morbidity and mortality after non‐curative gastrectomy for gastric cancer in elderly patients显示文摘 | Jung Ho Shim Kyung Jai Ko Han Mo Yoo Seong Il Oh Dong Jin Jeon Hae Myung Jeon Cho Hyun Park Kyo Young Song | 2012 | J Surg Oncol2012，，6： | 1 |
| 18 | The genome-wide expres- sion profile of scrophularia ningpoensis treated thapsigar- gin-stimulated U-87 MG cells 显示文摘 | Sohn SH Ko EJ Jeon SB | 2009 | Neuro Toxicol2009，30，3： | 1 |
| 19 | Effect of polymer cement modifiers on mechanical and physical properties of polymer-modifiedmortar using recycled artificial marble waste fine aggregate显示文摘 | Hwang E H Ko Y S Jeon J K | 2008 | Journal of Industrial and Engineering Chemistry2008，14，2： | 1 |
| 20 | Fast digital image stabilizer base on gray - coded bit - plane matching 显示文摘 | Sung - Jea Ko Sung - Hee Lee and Seung - Won Jeon | 1999 | IEEE Transactions on Consumer Electronics1999，，： | 1 |
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