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| 1 | Bone morphogenetic protein-2 gene controls tooth root development in coordination with formation of the periodontium显示文摘Formation of the periodontium begins following onset of tooth-root formation in a coordinated manner after birth. Dental follicle progenitor cells are thought to form the cementum, alveolar bone and Sharpey's fibers of the periodontal ligament (PDL). However, little is known about the regulatory morphogens that control differentiation and function of these progenitor cells, as well as the progenitor cells involved in crown and root formation. We investigated the role of bone morphogenetic protein-2 (Bmp2) in these processes by the conditional removal of the Bmp2 gene using the Sp7-Cre-EGFP mouse model. Sp7-Cre-EGFP first becomes active at E18 in the first molar, with robust Cre activity at postnatal day 0 (P0), followed by Cre activity in the second molar, which occurs after P0. There is robust Cre activity in the periodontium and third molars by 2 weeks of age. When the Bmp2 gene is removed from Sp7+ (Osterix+) cells, major defects are noted in root, cellular cementum and periodontium formation. First, there are major cell autonomous defects in root-odontoblast terminal differentiation. Second, there are major alterations in formation of the PDLs and cellular cementum, correlated with decreased nuclear factor IC (Nfic), periostin and α-SMA+ cells. Third, there is a failure to produce vascular endothelial growth factor A (VEGF-A) in the periodontium and the pulp leading to decreased formation of the microvascular and associated candidate stem cells in the Bmp2-cKOSp7-Cre-EGFP . Fourth, ameloblast function and enamel formation are indirectly altered in the Bmp2-cKOSp7-Cre-EGFP . These data demonstrate that the Bmp2 gene has complex roles in postnatal tooth development and periodontium formation. | Audrey Rakian Wu-Chen Yang Jelica Gluhak-Heinrich Yong Cui Marie A Harris Demitri Villarreal Jerry Q Feng Mary MacDougall Stephen E Harris | 2013 | International Journal of Oral Science2013，5，2： | 14 |
| 2 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 3 | Less common etiologies of exocrine pancreatic insufficiency显示文摘Exocrine pancreatic insufficiency(EPI), an important cause of maldigestion and malabsorption, results from primary pancreatic diseases or secondarily impaired exocrine pancreatic function. Besides cystic fibrosis and chronic pancreatitis, the most common etiologies of EPI, other causes of EPI include unresectable pancreatic cancer, metabolic diseases(diabetes); impaired hormonal stimulation of exocrine pancreatic secretion by cholecystokinin(CCK); celiac or inflammatory bowel disease(IBD) due to loss of intestinal brush border proteins; and gastrointestinal surgery(asynchrony between motor and secretory functions, impaired enteropancreatic feedback, and inadequate mixing of pancreatic secretions with food). This paper reviews such conditions that have less straightforward associations with EPI and examines the role of pancreatic enzyme replacement therapy(PERT). Relevant literature was identified by database searches. Most patients with inoperable pancreatic cancer develop EPI(66%-92%). EPI occurs in patients with type 1(26%-57%) or type 2 diabetes(20%-36%) and is typically mild to moderate; by definition, all patients with type 3 c(pancreatogenic) diabetes have EPI. EPI occurs in untreated celiac disease(4%-80%), but typically resolves on a gluten-free diet. EPI manifests in patients with IBD(14%-74%) and up to 100% of gastrointestinal surgery patients(47%-100%; dependent on surgical site). With the paucity of published studies on PERT use for these conditions, recommendations for or against PERT use remain ambiguous. The authors conclude that there is an urgent need to conduct robust clinical studies to understand the validity and nature of associations between EPI and medical conditions beyond those with proven mechanisms, and examine the potential role for PERT. | Vikesh K Singh Mark E Haupt David E Geller Jerry A Hall Pedro M Quintana Diez | 2017 | World Journal of Gastroenterology2017，23，39： | 5 |
| 4 | Association of types of diabetes and insulin dependency on birth outcomes显示文摘BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy outcomes.AIM To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes status.METHODS Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant mortality.Confounders included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm birth.Bivariate and multivariate logistic regression assessed differences in outcomes by diabetes status.RESULTS Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic women.Women with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic women.CONCLUSION Diabetes is associated with the poor birth outcomes.Clinical management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes. | Pamela K Xaverius Steven W Howard Deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere | 2022 | World Journal of Clinical Cases2022，10，7： | 2 |
| 5 | Fractal Analysis for Morphological Description of Corn Roots under Nitrogen Stress显示文摘 | Bahman E John R S Jerry W M | 1993 | Agronomy Journal1993，85，： | 1 |
| 6 | Cloning and functional expression of a cDNA encoding geranylgeranyl diphosphate synthase from Taxus canadensis and assessment of the role of this prenyhransferase in cells induced for taxol production 显示文摘 | Jerry Hefner Raymond E B Ketchum Rodney Croteau | 1998 | Arch Biochem Biophys1998，360，： | 1 |
| 7 | Laser forming for flexible fabrication 显示文摘 | Koiehi Masubuchi Jerry E Jones | 2000 | Journal of Ship Production2000，16，2： | 1 |
| 8 | Targeting telomerase-expressing cancer cells显示文摘 | Michel M O Woodring E W Jerry W S | 2011 | Journal of cellular and molecular medicine2011，15，7： | 1 |
| 9 | Vaugharu Nearly metacompact spaces显示文摘 | Elise Grabner Gary Grabner and Jerry E | 1999 | Topology and its Applications1999，98，： | 1 |
| 10 | Composition and varlability of leachate from recent and aged areas within a municipal landfill显示文摘 | John K Jerry E O F B D | 1995 | Water Environ Res1995，61，2： | 1 |
| 11 | Laser forming for flexi- ble fabrication显示文摘 | Koichi Masubuchi Jerry E Jones | 2000 | Journal of Ship Production2000，16，2： | 1 |
| 12 | More specifics on how inverters affect motors显示文摘 | David Hyypio P E Jerry Muehlbauer | 1997 | Power Transmission Design1997，，： | 1 |
| 13 | High temperature lead-free solder for microelectronics 显示文摘 | Framl W Gau e Gary Becka Jerry Badgett | 2001 | J Electron Mater2001，，6： | 1 |
| 14 | Maranville root development and nitrogen influx of corn genotypes grown under combined drought and N stress显示文摘 | BAHMAN E JERRY W | 1993 | Agron J1993，85，： | 1 |
| 15 | Residual energy scans for monitoring wireLess sensor networks显示文摘 | GOVINDAN R DEBORAH E | 2002 | IEEE Wireless Communications and Networking Conference2002，3，： | 1 |
| 16 | Dissimilar friction welding of 6061-T6 aluminum and AISI 1018 steel: Properties and microstructural characterization显示文摘 | EMEL T JERRY E GOULD B JOHN C L | 2010 | Materials and Design2010，31，： | 1 |
| 17 | Optimization of point target tracking filters显示文摘 | Charlene E C Jerry S | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，1： | 1 |
| 18 | Techniques and tools for quality and reliability improvement显示文摘 | Soden Jerry M Anderson Richard E IC failure analysis | 1993 | Proceedings of the IEEE1993，，： | 1 |
| 19 | Mechanism of apoptosis induction by inhibition of the anti-apoptotic Bcl-2 proteins 显示文摘 | Jerry E Chipuk John C Fisher Christopher P Dillon | 2008 | Nat Acad Sci USA2008，105，20： | 1 |
| 20 | A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines显示文摘 | Gerard F Hess Roger F Drong Katherine L Weiland Jerry L Slightom Robert A Sclafani Robert E Hollingsworth | 1998 | Gene1998，，1： | 1 |
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