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| 1 | Comparison of esophageal capsule endoscopy and esophagogastroduodenoscopy for diagnosis of esophageal varices显示文摘AIM: To investigate the utility of esophageal capsule endoscopy in the diagnosis and grading of esophageal varices. METHODS: Cirrhotic patients who were undergo-ing esophagogastroduodenoscopy (EGD) for variceal screening or surveillance underwent capsule endos-copy. Two separate blinded investigators read each capsule endoscopy for the following results: variceal grade, need for treatment with variceal banding or prophylaxis with beta-blocker therapy, degree of portal hypertensive gastropathy, and gastric varices. RESULTS: Fifty patients underwent both capsule and EGD. Forty-eight patients had both procedures on the same day, and 2 patients had capsule endoscopy within 72 h of EGD. The accuracy of capsule endos- copy to decide on the need for prophylaxis was 74%, with sensitivity of 63% and specificity of 82%. Inter-rater agreement was moderate (kappa = 0.56). Agree-ment between EGD and capsule endoscopy on grade of varices was 0.53 (moderate). Inter-rater reliability was good (kappa = 0.77). In diagnosis of portal hyper-tensive gastropathy, accuracy was 57%, with sensitiv-ity of 96% and specificity of 17%. Two patients had gastric varices seen on EGD, one of which was seen on capsule endoscopy. There were no complications from capsule endoscopy.CONCLUSION: We conclude that capsule endoscopy has a limited role in deciding which patients would benefit from EGD with banding or beta-blocker thera-py. More data is needed to assess accuracy for staging esophageal varices, PHG, and the detection of gastric varices. | Catherine T Frenette John G Kuldau Donald J Hillebrand Jill Lane Paul J Pockros | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Diabetes mellitus increases risk for colorectal adenomas in younger patients显示文摘AIM:To determine if diabetes mellitus(DM)is associated with increased risk of colorectal adenomas in younger subjects.METHODS:This was a retrospective cohort study of375 patients undergoing index colonoscopy at a single tertiary care center in the United States.Three cohorts of patients matched for exam date and gender were compared:(1)ages 40-49 years with DM;(2)ages40-49 years without DM;and(3)ages 50-59 years without DM.Data collected included demographics,co-morbidities,colonoscopy and pathology results.Adenoma detection rates(ADR)were calculated and compared.Conditional logistic regression analysis was performed to determine the association between each cohort and ADR.RESULTS:One hundred and twenty-five patients ages40-49 with DM met study eligibility criteria.Patients in the other two cohorts were randomly selected,match-ing for date of exam and gender.ADR was 14.4%in those ages 40-49 years without DM,30.4%in those ages 40-49 years with DM,and 32.0%in those ages50-59 years without DM.Compared to those ages40-49 years without DM,ADR was higher in those ages40-49 years with DM(OR=3.1;95%CI:1.5-6.4;P=0.002)and those ages 50-59 years without DM(OR=2.9;95%CI:1.5-5.6;P=0.002).There was no difference between the ADR in those ages 40-49 years with DM and those ages 50-59 years without DM(P=0.83).CONCLUSION:DM was associated with higher risk of colorectal adenomas in patients ages 40-49 years.These subjects harbored as many adenomas as those at the standard screening age of 50-59 years without DM. | Hongha T Vu Nneka Ufere Yan Yan Jean S Wang Dayna S Early Jill E Elwing | 2014 | World Journal of Gastroenterology2014，20，22： | 5 |
| 3 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 4 | ICAM - 1 gene expression by glial cells: differential mechanisms of inhibition by interleukin- 10 and interleukin - 6 显示文摘 | Shrikant P Weber E Jilling T | 1995 | J Immunol1995，155，： | 1 |
| 5 | Development of a laser Raman spectrometer for deep-ocean science显示文摘 | Peter G Brewer George Malby Jill D Pasteris Sheri N White Edward T Peltzer B Wopenka J Freeman Mark O Brown | 2004 | Deep-Sea Research Part I2004，，5： | 1 |
| 6 | Development,characterization,efficacy and mode of action of ambisome,a unilamellar liposomal formulation of amphotericin B显示文摘 | JILL P A RICHARD T P | 1993 | J Liposome Res1993，3，3： | 1 |
| 7 | New concepts in necrotizing entero- colitis显示文摘 | Caplan MS Jilling T | 2001 | Curt Opin Pediatr2001，13，2： | 1 |
| 8 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 9 | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis显示文摘 | CAPLAN M S JILLING T | 2001 | Lipids2001，36，： | 1 |
| 10 | Development characterization efficacy and mode of action of AmB-L, a unilemellar liposomal formulation of amphotericin B 显示文摘 | Jill P Adler M Richard T | 1993 | J Lipos Res1993，3，： | 1 |
| 11 | New concepts in necrotizing enterocolitis显示文摘 | Caplan MS Jilling T | 2001 | Curr Oin Pediatr2001，13，4： | 1 |
| 12 | The roles of bacteria and TLR4 in rat and murine models of necrotizing enteroeolitis 显示文摘 | Jilling T Simon D Lu J | 2006 | J Immunol2006，177，5： | 1 |
| 13 | The role of PAF, TLR, and the inflammatory response in neonatal necrotizing enterocolitis显示文摘 | Caplan MS Simon D Jilling T | 2005 | Semin Pediatr Surg2005，14，3： | 1 |
| 14 | Intestinal epithelial apoptosis initiates gross bowel necrosis in an experimental rat model of neonatal necrotizing enterocolitis显示文摘 | Jilling T Lu J Jackson M | | 0，，04： | 1 |
| 15 | The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal neerotizing enterocolitis显示文摘 | Caplan MS Jilling T | 2001 | Lipids2001，36，9： | 1 |
| 16 | The importance of pro -inflammatory signaling in neonatal necrotizing enterocolitis 显示文摘 | Frost BL Jilling T Caplan MS | 2008 | Semin Perinatol2008，32，2： | 1 |
| 17 | New concepts in necrotizing enterocolitis显示文摘 | Capian MS Jilling T | 2001 | Cur Opin Pediatr2001，13，2： | 1 |
| 18 | The role of PAF,TLR,and the inflammatory response in neonatal necrotizing enterocolitis 显示文摘 | Caplan MS Simon D Jilling T | 2005 | Semin Pediatr Surg2005，14，3： | 1 |
| 19 | A Method for Calibrating Deterministic Forecasts of Rare Events显示文摘 | Marsh Patrick T Kain John S Lakshmanan Valliappa Clark Adam J Hitchens Nathan M Hardy Jill | 2012 | EN2012，，2： | 1 |
| 20 | New concepts in necrotizing enterocolitis显示文摘 | Caplan MS Jilling T | 2001 | Cur Opin Pediatr2001，13，2： | 1 |
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