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| 1 | 甲状腺乳头状癌诊断与鉴别的可靠标记物显示文摘目的寻找更好的标记物,用于甲状腺乳头状癌的诊断与鉴别。方法以甲状腺乳头状癌(PTC)为研究组,以甲状腺滤泡状腺瘤(FA)和良性乳头状病变(BPL)作对照组。经自制组织芯片和免疫组化技术,对Twist、Galectin-3、HBME-1、p14ARF和TPO进行标记,并与CK19对比实验。结果6种指标阳性表达率依次为:PTC组100.0%、95.6%、80.0%、28.9%、15.6%和78.0%;FA组0.0、11.1%、6.7%、75.6%、88.9%和0.0;BPL组7.0%、7.5%、2.5%、77.5%、100.0%和0.0。PTC组与FA和BPL组比较差异均有显著性(P<0.05)。6种指标的灵敏度、特异度、准确度分别为100.0%、95.6%、80.0%、71.1%、84.4%、78.0;96.4%、90.1%、95.3%、76.5%、94.1%、100.0%和97.7%、92.3%、90.0%、74.6%、90.8%、91.9%。结论在PTC中6种指标阳性表达率最高的为Twist,其次为Galectin-3,因此临床病理工作中标记Twist和Galectin-3鉴别PTC与FA或BPL有实用意义。Twist的灵敏度和准确度最高,CK19特异度最高。因此该2种指标联合使用对于PTC的鉴别诊断最可靠。 | 何春年 Lili H Jin Q CH 陈士超 赵焕芬 翟金萍 | 2007 | 临床与实验病理学杂志2007，23，6： | 14 |
| 2 | Association of nonalcoholic fatty liver disease with type 2 diabetes: clinical features and independent risk factors in diabetic fatty liver patients显示文摘Nonalcoholic fatty liver disease(NAFLD) is a common chronic liver disease in China, of which diabetic fatty liver (DFL) accounts for a large proportion in clinic. DFL is a disease without specific clinical features and lacking of confirmatory laboratory tests, and the etiology of hepatic steatosis remains poorly understood. The aim of this paper was to explore the clinical characteristics and to determine associated risk factors in type 2 diabetes patients with fatty liver. METHODS: A total of 166 patients, 53 in DFL group and 113 in NDFL(diabetes without fatty liver) group participated in this study. Serum fasting blood glucose (FBG), alanine aminotransferase(ALT), aspartate aminotransferase (AST), alkaline phosphate (AKP), gamma glutamyl transpeptidase (GGT), total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) were measured in both groups. And these variables were analyzed by using Student’ s t test and logistic regression model. RESULTS:A progressive increase in the level of FBG, ALT, AST, AKP, GGT, TG( P<0.05) and a decrease of HDL-C(P<0.01)were observed from DFL group to NDFL group. And there was no statistical difference in the level of TC between the two groups. CONCLUSIONS:Dyslipidemia, dysglycemia and elevation of liver enzyme can be seen more frequently in the DFL patients than in the NDFL patients. The successive escalation of serum ALT and TG levels and the lower HDL-C level are the independent risk factors of DFL. | Department of Digestive Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China (Jin HB, Gu ZY, Yu CH and Li YM) | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 9 |
| 3 | Capilliposide from Lysimachia capillipes inhibits AKT activation and restores gefitinib sensitivity in human non-small cell lung cancer cells with acquired gefitinib resistance显示文摘有非小的房间肺癌症(NSCLC ) 的最对待 gefitinib 的病人将最后开发抵抗。从 LC Hemsl 的 Lysimachia capillipes (LC ) capilliposide 摘录。在 vitro 并且在 vivo 反癌症效果出现。在这研究,我们调查了在有 gefitinib 的联合的 LC capilliposide 是否能克服 NSCLC 房间的抵抗到 gefitinib 并且识别包含的发信号的小径。有 LC capilliposide 的治疗独自禁止了 NSCLC 房间线(PC-9, H460, H1975, H1299 和 PC-9-GR ) 的一块面板的生长对有在 g/mL 的范围的 IC 50 价值的 gefitinib 敏感或抵抗。在 gefitinib 抵抗的 PC-9-GR 房间(它有一个 T790M EGFR 变化) , LC capilliposide (在 IC30, i.e.1.2 g/mL ) 显著地与它的 IC50 价值提高了 gefitinib 的禁止的效果从 6.80 | Shi-rong ZHANG Ya-si XU Er JIN Lu-cheng ZHU Bing XIA Xu-feng CH EN Fan-zhu LI Sheng-lin MA | 2017 | Acta Pharmacologica Sinica2017，38，1： | 7 |
| 4 | A new orally available glucagon- like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice 显示文摘 | Jin CH Chae SY Son S | 2009 | J Control Release2009，133，： | 1 |
| 5 | In-situ formation of the hydroxyapatite/chitosan-alginate composite scaffolds 显示文摘 | Jin HH Lee CH Lee WK | 2008 | Mater Left2008，62，1011： | 1 |
| 6 | Sleep problems in chinese school- aged children with a parent-reported history of ADHD 显示文摘 | Li SH Jin XM Yan CH | 2009 | J Atten Disord2009，13，1： | 1 |
| 7 | Effects of subchronic aluminumexposure on spatial memory, ultrastructure and L-LTP of hippocampusin rats显示文摘 | ZhangLF Jin CH Liu QF | 2013 | Toxicolog Sci2013，38，： | 1 |
| 8 | The inhibitory effect of interleukin 10 on mouse osteoclast formation involves no- vel tyrosine- phosphorylated proteins 显示文摘 | Hong MH Williams H Jin CH | 2000 | J Bone Miner Res2000，15，5： | 1 |
| 9 | Aversive parenting in china:Associations with child physical and relational aggression显示文摘 | NELSON DA HART CH JIN S | 2006 | Child Dev2006，77，3： | 1 |
| 10 | RANKL inhibition through osteoproteger in blocks bone loss in experimental periodontitis显示文摘 | Jin Q Cirelli JA Park CH | 2007 | J Periodontol2007，78，7： | 1 |
| 11 | RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis 显示文摘 | Jin Q Cirelli JA Park CH | 2007 | J Periodontol2007，78，7： | 1 |
| 12 | Effect of tumor necrosis factor-related apoptosis-inducing ligand on the reduction of joint inflammation in experimental rheumatoid arthritis 显示文摘 | Jin CH Chae SY Kim TH | 2010 | Pharmacol Exp Ther2010，332，3： | 1 |
| 13 | Preparation of nano-TiO2/ polyurethane emulsions via in situ RAFT polymerization 显示文摘 | CHE X CH JIN Y Z LEE Y S | 2010 | Progress in Organic Coatings2010，69，： | 1 |
| 14 | Propagation of High-Power Parabolic Pulses in Cubicon Fiber Amplifiers显示文摘 | ZHANG S JIN Ch MENG Y | | 0，，： | 1 |
| 15 | Metamaterial-inspired engineering of antennas显示文摘 | Ziolkowski R W Jin P Lin Ch Ch | 2011 | PROCEEDINGS OF THE IEEE2011，99，10： | 1 |
| 16 | Factors associated with recurrence inpatients with curatively resected stage l-ll lung cancer显示文摘 | Koo HK Jin SM Lee CH | 2011 | Lung Cancer2011，73，2： | 1 |
| 17 | Structure of severe fever with thrombocytopenia syndrome virus nucleocapsid protein in complex with suramin reveals therapeutic potential显示文摘 | Jiao L Ouyang S Liang M Niu F Shaw N Wu W Ding W Jin C Peng Y Zhu Y Zhang F Wang T Li C Zuo X Luan CH Li D Liu ZJ | 2013 | J Virol2013，87，12： | 1 |
| 18 | Factors associated with recur- rence in patients with curatively resected stage I -I1 lung cancer 显示文摘 | Koo HK Jin SM Lee CH | 2011 | Lung Cancer2011，73，： | 1 |
| 19 | The biological roles of the third component of complement in osteoclast formation显示文摘 | Sato T Abe E Jin CH Hong MH | 1993 | Endocrinology1993，133，1： | 1 |
| 20 | RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis显示文摘 | Jin Q Cirelli JA Park CH | 2007 | J Periodontol2007，78，7： | 1 |
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