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| 1 | Niederaussem电站1000MW超临界汽轮机(英文)显示文摘 本文对Niederau?emK电站汽轮机的初始运行情况展开讨论,并对已使用的最新技术进行了详细的论述。 | Wilfried Ulm Dale Ernette John Kern Ralf M. Bell | 2003 | 热力透平2003，，1： | 3 |
| 2 | DNA-PK抑制剂联合溶瘤病毒增强对肝癌的抗肿瘤活性研究显示文摘目的:寻找协同增强VSVΔ51溶瘤病毒(OV)对肝癌杀伤作用的小分子化合物并探索其协同机制。方法:通过将不同机制的抗肿瘤活性的小分子化合物与VSVΔ51联合,筛选对肝癌细胞裂解能力最强的药物组合;通过体内抑瘤能力实验检测联合疗法的体内抗肿瘤活性;通过电镜观测联合疗法处理后内质网的肿胀程度及Western blot检测肿瘤组织中凋亡相关蛋白的水平,探索联合疗法协同增效的机制。结果:细胞存活实验表明,DNA-PK抑制剂M3814与VSVΔ51联合后较M3814单独给药细胞毒性明显增强,沉默靶细胞DNA-PKcs基因后也能显著增强VSVΔ51的肿瘤裂解能力(P<0.0001);体内实验表明,M3814与VSVΔ51联合治疗较单独治疗而言肿瘤抑制能力显著增强(P<0.001);电镜观测结果显示M3814与VSVΔ51联合处理靶细胞后内质网肿胀程度增加(P<0.001),Western blot检测结果表明,M3814与VSVΔ51联合治疗后的肿瘤组织中凋亡相关蛋白表达增加(P<0.001)。结论:M3814联合VSVΔ51可以增强内质网应激诱导肝癌细胞凋亡,有可能为肝癌的治疗提供新的方案。 | 吴育民 杜端明 刘春霖 洪跃飞 江磊昌 罗伟芝 彭尧 JOHN Bell | 2021 | 中国免疫学杂志2021，37，18： | 3 |
| 3 | Efficacy of Transoral Fundoplication vs Omeprazole for Treatment of Regurgitation in a Randomized Controlled Trial显示文摘 | John G. Hunter Peter J. Kahrilas Reginald C.W. Bell Erik B. Wilson Karim S. Trad James P. Dolan Kyle A. Perry Brant K. Oelschlager Nathaniel J. Soper Brad E. Snyder Miguel A. Burch William Scott Melvin Kevin Reavis Daniel G. Turgeon Eric S. Hungness Brian | 2014 | Gastroenterology2014，，： | 2 |
| 4 | Long-term outcomes after fractional flow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis显示文摘Objective To explore the safety and efficacy of FFR-guided percutaneous coronary intervention (PCI) in vessels with severe diameter stenosis. Methods & Results Of 1090 patients undergoing fractional flow reserve (FFR) assessment from 2002 to 2009,we identified 167 patients in whom FFR was measured in at least one 70%–89% stenotic lesion. These patients were subdivided into an FFR-defer group (n = 49) if PCI was deferred (FFR > 0.80),and an FFR-perform group (n = 118) if PCI was performed (FFR ≤ 0.80). Comparatively,an additional 1176 patients undergoing PCI in at least one lesion with 70%–89% stenosis but without measurement of FFR served as a control (angiography- guided) group. Clinical outcomes were compared during a median follow-up of 49.0 months. The 5-year Kaplan-Meier estimated revascularization rates were 16% in the FFR-defer group and 33% in the FFR-perform group (P = 0.046). The incidence of major adverse cardiac events were comparable in these two groups (HR = 0.82,95% CI: 0.37–1.82,P = 0.63). The number of stents placed was significantly lower in the FFR-guided group (0.9 ± 0.8 vs. 1.4 ± 0.8,P < 0.001). Conclusions Functional revascularization for lesions with visually severe stenosis is clinically safe and associated with fewer stents use. This study suggests that extending the use of FFR to more severe coronary lesions may be reasonable. | Ying-Hua ZHANG Jing LI Andreas J. Flammer Yoshiki Matsuo Moo-Sik Lee Ryan J. Lennon Malcolm R. Bell David R. Holmes John F. Bresnahan Charanjit S. Rihal Lilach O. Lerman Amir Lerman | 2019 | Journal of Geriatric Cardiology2019，16，4： | 2 |
| 5 | Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: A survival prediction model to facilitate clinical decision making显示文摘 | Andrew W. Bradbury Donald J. Adam Jocelyn Bell John F. Forbes F. Gerry R. Fowkes Ian Gillespie Charles Vaughan Ruckley Gillian M. Raab | 2010 | Journal of Vascular Surgery2010，，： | 2 |
| 6 | Cancellation of GLONASS signals from radio astronomy da- ta 显示文摘 | ELLINGSON Steven W BUNTON John D BELL Jon F | 2009 | The Smithsonian/NASA Astrophysics Data System2009，4015，： | 1 |
| 7 | Bypass versus Angioplasty in Severe Ischaemia of the Leg (BASIL) trial: An intention-to-treat analysis of amputation-free and overall survival in patients randomized to a bypass surgery-first or a balloon angioplasty-first revascularization strategy显示文摘 | Andrew W. Bradbury Donald J. Adam Jocelyn Bell John F. Forbes F. Gerry R. Fowkes Ian Gillespie Charles Vaughan Ruckley Gillian M. Raab | 2010 | Journal of Vascular Surgery2010，，： | 1 |
| 8 | Ant colony optimization techniques for the vehicle routing problem显示文摘 | John E Bell Patrick R McMullen | 2004 | Advanced Engineering Informatics2004，18，1： | 1 |
| 9 | Endothelial dysfunction:implication for therapy of cardiovascular diseases显示文摘 | Bell DM Johns TE Lopez LM | 1998 | Ann Pharmacother1998，32，4： | 1 |
| 10 | Soil Microbial Responses to Temporal Variations of Moisture and Temperature in a Chihuahuan Desert Grassland显示文摘 | Colin Bell Nancy McIntyre Stephen Cox David Tissue John Zak | 2008 | Microbial Ecology2008，，1： | 1 |
| 11 | Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans显示文摘 | Mark J. Graham Richard G. Lee Thomas A. Bell Wuxia Fu Adam E. Mullick Veronica J. Alexander Walter Singleton Nick Viney Richard Geary John Su Brenda F. Baker Jennifer Burkey Stanley T. Crooke Rosanne M. Crooke | 2013 | Circulation Research2013，，11： | 1 |
| 12 | Influence of synthesis route on the catalytic properties of La1-xSrxMnO3显示文摘 | Millar Graeme J Drennan John | 2000 | Solid State Ionics2000，131，： | 1 |
| 13 | Organization and differential activation of a gene family encoding the plant defense enzyme chalcone synthase in Phaseolus vulgaris显示文摘 | THOMAS B RYDER SUSAN A HEDRICK JOHN N Bell | 1987 | Mol Gen Genet1987，210，： | 1 |
| 14 | The long-term retention of pregabalin in a large cohort of patients with epilepsy at a tertiary referral centre显示文摘 | Alan W.C. Yuen Rinki Singh Gail S. Bell Anupam Bhattacharjee Aidan Neligan Dominic C. Heaney John S. Duncan Josemir W. Sander | 2009 | Epilepsy Research2009，，2： | 1 |
| 15 | Vitamin D Deficiency显示文摘 | John H. Lee James H. O’Keefe David Bell Donald D. Hensrud Michael F. Holick | 2008 | Journal of the American College of Cardiology2008，，24： | 1 |
| 16 | Cognitive-Behavior therapy for depressed cancer patients in a medical care setting显示文摘 | Derek R John L Bell Lejuez CW | 2008 | Hopko Behavior therapy2008，39，1： | 1 |
| 17 | Prevalence of extended spectrum β-lactamase (ESBL)-producing clinical isolates in the Asia-Pacific region and South Africa: regional results from SENTRY Antimicrobial Surveillance Program (1998–99)显示文摘 | Jan M. Bell John D. Turnidge Ana C. Gales Michael A. Pfaller Ronald N. Jones | 2002 | Diagnostic Microbiology & Infectious Disease2002，，3： | 1 |
| 18 | The long-term outcome of adult epilepsy surgery, patterns of seizure remission, and relapse: a cohort study显示文摘 | Jane de Tisi Gail S Bell Janet L Peacock Andrew W McEvoy William FJ Harkness Josemir W Sander John S Duncan | 2011 | The Lancet2011，，9800： | 1 |
| 19 | 东非碳酸岩的Nd和Sr同位素对地幔不均一性的指示作用显示文摘在~εSr—~εNd图解上,东非一些年轻碳酸岩的Sr、Nd同位素数据呈很好的反相关关系。用包括大陆地壳在内的一种简单混合模式无法解释这一结果,所以选择两种不同幔源的混合模式来解解。与主体地球(bulk earth)相比,一种源岩贫大离子亲石元素,另一种则稍富,前者与某些加拿大碳酸岩的结果一致。 | Keith Bell John Blenkinsop 邱玉民 | 1989 | 世界地质1989，8，1： | 1 |
| 20 | Functional and structural diversity of the human Dickkopf gene family显示文摘 | Valery E. Krupnik John D. Sharp Chian Jiang Keith Robison Troy W. Chickering Lakshmi Amaravadi Diane E. Brown Deborah Guyot Gail Mays Kevin Leiby Belle Chang Thao Duong Andrew D.J. Goodearl David P. Gearing Sergei Y. Sokol Sean A. McCarthy | 1999 | Gene1999，，2： | 1 |
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