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| 1 | Brain Metastases Treated with Radio surgery Alone:An Alternative to Whole Brain Radiotherapy?显示文摘OBJECTIVE:Whole brain radiotherapy(WBRT)provides benefit for patients with b rain metastases but may result in neurological toxicity for patien ts with extended survival times.Ste reotactic radiosurgery in combination with WBRT has become an important approach,but the value of WBRT has been questioned.As an alternative to WBRT,we managed patients with stereotactic radiosurgery alone,evaluated pati ents’outcomes,and assessed prognostic factors for survival and tumor c ontrol.METHODS:One hundred seventy-two patients with b rain metastases were managed with ra diosurgery alone.One hundred twent y-one patients were evaluable with follow-up imaging after radiosurgery.The median patien t age was 60.5years(age range,16-86yr).The mean marginal tumor dose and volume were 18.5Gy (range,11-22Gy )and 4.4ml (range,0.1-24.9ml ).Eighty percent of patients had soli tary tumors.RESULTS:The overall median survival time was8months.The median survival time in patients with no evidence of primary tumor disease or stable disease was 13and 11months.The local tumor contr ol rate was 87%.At 2years,the rate of local control,remote brain control,and total intr acranial control were 75%,41%,and 27%,respectively.In multivariate a nalysis,advanced primary tumor status(P=0.0003),older age(P=0.008),lower Karnofsky Performance Scale score(P=0.01),and malignant melanoma (P=0.005)were significant for poorer surviva l.The median survival time was 28mon ths for patients younger than 60years of age,with Karnofsky Performance Scale score o f at least 90,and whose primary tumor status showed either no evidence of disease or stable disease.Tumor volume (P=0.02)alone was significant for local tumo r control,whereas no factor affecte d remote or intracranial tumor contr ol.Eleven patients developed complica tions,six of which were persistent.Nineteen(16.5%)of 116patients in whom the cause of death was obtained died as a result of cause s related to brain metastasis.CONCLUSION:Brain metastases were controlled we ll with radiosurgery alone as initial thera py.We advocate that WBRT should not be part of the initial treatment proto col for selected patients with one or two tumors with good control of their primary cancer,better Karnofsky Performance Scale score,and you nger age,all of which are predictors of longer | Toshinori Hasegawa Douglas Kondziolka John C.Flickinger Anand Germanwala L.Dade Lunsford | 2003 | 癌症2003，22，7： | 23 |
| 2 | 更好地报告随机试验中的危害:CONSORT声明扩展版显示文摘面对随机对照试验(RCTs)报告质量过低的种种确凿证据和严重后果,许多医学杂志及编辑小组现已接受并支持一份包含有22个条目的清单和一个流程图的CONSORT声明(试验报告统一标准)。由于CONSORT的主旨是提高干预措施疗效的报告质量,故其中只有一个条目是具体针对安全性的。大量证据表明,报告RCT中的危害的相关数据的报告质量有待提高。2003年5月,CONSORT小组成员,包括杂志编辑和科学家,齐聚加拿大魁北克省Mentoebello探讨了这一问题,并形成以下文件:标准CONSORT清单附带报告危害相关问题的10个新推荐意见,并附上说明及恰当报告的实例。我们希望该声明连同其它CONSORT相关材料(www.consort-statement.org)将有助于作者提高RCT报告中与危害相关数据的报告质量。高质量报告有助于读者批判性评价和诠释试验结果。各杂志可通过修改稿约来向作者传达这一文件以支持这一目标。 | John P.A.Ioannidis Stephen J.W.Evans Peter C.G■tzsche Robert T.O’Neill Douglas G.Altman Kenneth Schulz David Moher 杜亮 | 2006 | 中国循证医学杂志2006，6，9： | 12 |
| 3 | In Vivo Phosphorylation Site Mapping and Functional Characterization of Arabidopsis Phototropin 1显示文摘Phototropins (phot1 和 phot2 ) 是控制优化植物的光合的效率的回答的一个范围的蓝光的受体 kinases。察觉到的光被二个黄素绑定主题调停,作为 LOV1 和 LOV2 知道,在蛋白质的 N 终端区域以内定位了。经由 LOV2 的 Photoexcitation 导致 C 终端 kinase 领域并且因而的激活受体 autophosphorylation。然而,为 Arabidopsis phototropins 的 in-vivo phosphorylation 地点的知识在阐明正在缺乏并且阻碍了进步受体 phosphorylation 的功能的意义。我们从 Arabidopsis 净化了 phot1 并且由液体层析双人脚踏车团 spectrometry 识别了受体 phosphorylation 的 in-vivo 地点。导出 Arabidopsis 的 phot1 作为色基绑黄素 mononucleotide 并且是在 LOV2 (Ser58, Ser85, Ser350,和 Ser410 ) 在上游的定位的四个主要地点的 phosphorylated。不过,结构功能分析显示 phot1 的生物活动能被归因于包括蛋白质的 LOV2-kinase 区域的一个模块化的单位。因此,包括这里识别的受体 phosphorylation 的地点, LOV2 在上游的肽区域不看起来为受体发信号重要。由对比,这些区域可能为最大化是必要的有气孔的性能和 phot1 的可能导致光的本地化。 | Stuart Sullivan Catriona E. Thomson Douglas J. Lamont Matthew A. Jones John M. Christie | 2008 | Molecular Plant2008，1，1： | 11 |
| 4 | 系统综述与网状Meta分析的PRISMA扩展声明显示文摘PRISMA声明旨在提高系统综述和META分析报告的完整性,该声明已经广泛用于指导系统综述和META分析的报告和发表。原始的PRISMA声明是针对两种干预措施比较的传统的系统综述与META分析而制定的,然而,随着多种干预措施比较的系统综述的发展,实施和报告这一类系统综述面临较大挑战。此时,针对网状META分析的PRISMA扩展声明应运而生,旨在提高网状META分析系统综述的报告质量。PRISMA扩展声明是由专家们通过DELPHI调查、面对面讨论和共识大会而最终确立的。PRISMA扩展声明是在原始PRISMA声明的报告清单的基础上经过修改,最终确定了32个条目,每个条目均与网状META分析报告的内容直接相关。本文对网状META分析的PRISMA扩展声明进行了阐述,对报告清单各条目进行了举例说明,并详细说明了在原始PRISMA声明的基础上新增和修改各条目的理由。此外,PRISMA扩展声明强调了在网状META分析的实际操作中需要重点关注的信息。本文的目标读者包括网状META分析的作者与读者,以及期刊杂志的编辑与同行评审。 | 李志霞 杨俊 叶欣 周凌波 杨智荣 孙凤 詹思延 Brian Hutton Georgia Salanti Deborah M.Caldwell Anna Chaimani Christopher H.Schmid Chris Cameron John P.A.Ioannidis Sharon Straus Kristian Thorlund Jeroen P.Jansen Cynthia Mulrow Ferrán Catalá-López Peter C.Gozsche Kay Dickersin Isabelle Boutron Douglas G.Altman David Moher | 2016 | 中国循证心血管医学杂志2016，8，6： | 11 |
| 5 | Screening and Surveillance for the Early Detection of Colorectal Cancer and Adenomatous Polyps, 2008: A Joint Guideline From the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology显示文摘 | Bernard Levin David A. Lieberman Beth McFarland Kimberly S. Andrews Durado Brooks John Bond Chiranjeev Dash Francis M. Giardiello Seth Glick David Johnson C. Daniel Johnson Theodore R. Levin Perry J. Pickhardt Douglas K. Rex Robert A. Smith Alan Thorson S | 2008 | Gastroenterology2008，，5： | 8 |
| 6 | Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence显示文摘 | Laura J. Havrilesky Clark M. Whitehead Jennifer M. Rubatt Robert L. Cheek John Groelke Qin He Douglas P. Malinowski Timothy J. Fischer Andrew Berchuck | 2008 | Gynecologic Oncology2008，，3： | 7 |
| 7 | Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit显示文摘 | Juliana Barr Gilles L. Fraser Kathleen Puntillo E. Wesley Ely Céline Gélinas Joseph F. Dasta Judy E. Davidson John W. Devlin John P. Kress Aaron M. Joffe Douglas B. Coursin Daniel L. Herr Avery Tung Bryce R. H. Robinson Dorrie K. Fontaine Michael A. Ramsa | 2013 | Critical Care Medicine2013，，1： | 6 |
| 8 | Risk factors for post-ERCP pancreatitis: A prospective, multicenter study显示文摘 | Martin L. Freeman James A. DiSario Douglas B. Nelson M.Brian Fennerty John G. Lee David J. Bjorkman Carol S. Overby Johannes Aas Michael E. Ryan Gary S. Bochna Michael J. Shaw Harry W. Snady Robert V. Erickson Joseph P. Moore Joseph P. Roel | 2001 | Gastrointestinal Endoscopy2001，，4： | 5 |
| 9 | Quality indicators for colonoscopy显示文摘 | Douglas K. Rex John L. Petrini Todd H. Baron Amitabh Chak Jonathan Cohen Stephen E. Deal Brenda Hoffman Brian C. Jacobson Klaus Mergener Bret T. Petersen Michael A. Safdi Douglas O. Faigel Irving M. Pike | 2006 | Gastrointestinal Endoscopy2006，，4： | 4 |
| 10 | 加拿大阿尔伯塔省土地利用交通模型的发展(英文)显示文摘加拿大阿尔伯塔省经济的飞速发展,使得为全省制定合理的交通规划成为一项迫切的任务,在这种情况下,本文提出了全省的土地利用交通模型.该模型以PECAS(生产、交易和消费分派系统)结构为基础,实质是在整体经济的前提下考虑基本的交通需求(商品、服务、劳动力交换的流通过程)而进行交通规划.生产、交易和消费分派系统是一种空间经济模拟系统,它侧重交通规划和发展规划,近几年在美国提出并在一些州和城市得到应用.阿尔伯塔省土地利用交通模型受其模型建立基础,尤其是MEPLAN和TRANUS模型的影响,但该模型在理论基础和行为描述上都做了明显的改进.本文从数据源和标定方法方面介绍加拿大阿尔伯塔省的土地利用交通模型的建立和发展. | 钟鸣 John Douglas Hunt John Edward Abraham | 2007 | 交通运输系统工程与信息2007，7，1： | 4 |
| 11 | Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients With Inflammatory Bowel Disease显示文摘 | Uma Mahadevan Douglas C. Wolf Marla Dubinsky Antoine Cortot Scott D. Lee Corey A. Siegel Thomas Ullman Sarah Glover John F. Valentine David T. Rubin Jocelyn Miller Maria T. Abreu | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 4 |
| 12 | A Global Perspective on Irritable Bowel Syndrome: A Consensus Statement of the World Gastroenterology Organisation Summit Task Force on Irritable Bowel Syndrome显示文摘 | Eamonn M. M. Quigley Hussein Abdel-Hamid Giovanni Barbara Shobna J. Bhatia Guy Boeckxstaens Roberto De Giorgio Michel Delvaux Douglas A. Drossman Amy E. Foxx-Orenstein Francisco Guarner Kok-Ann Gwee Lucinda A. Harris A. Pali S. Hungin Richard H. Hunt John | 2012 | Journal of Clinical Gastroenterology2012，，5： | 4 |
| 13 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 4 |
| 14 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 15 | Quality in the technical performance of colonoscopy and the continuous quality improvement process for colonoscopy: recommendations of the U.S. Multi-Society Task Force on Colorectal Cancer显示文摘 | Douglas K Rex John H Bond Sidney Winawer Theodore R Levin Randall W Burt David A Johnson Lynne M Kirk Scott Litlin David A Lieberman Jerome D Waye James Church John B Marshall Robert H Riddell | 2002 | The American Journal of Gastroenterology2002，，6： | 3 |
| 16 | 当在小肠的囊内视镜检查法计算路易斯分数时,蓝模式不在白光上提供任何利益显示文摘 AIM: To check the usefulness of blue mode (BM) review in lewis score (LS) calculation, by comparing it with respective LS results obtained by white light (WL) small-bowel capsule endoscopy (SBCE) review and mucosal inflammation as reflected by faecal calprotectin (FC) levels, considered as ’gold standard’ for this study. METHODS: Computational analysis of our SBCE database to identify patients who underwent SBCE with PillCam? and had FC measured within a 30-day period from their test. Only patients with prior colonoscopy were included, to exclude any colon pathology-associated FC rise. Each small bowel tertile was reviewed (viewing speed 8 fps) with WL and BM, in a back-to-back mode, by a single experienced reviewer. LS were calculated after each WL and BM reviews. Pearson rank correlation (rho, r) statistic was applied.RESULTS: Twenty-seven (n = 27, 20F/7M) patients were included. Thirteen (n = 13) had SBCE with PillCam?SB1, and the remainder (n = 14) with PillCam? SB2. The median level of FC in this cohort was 125 μg/g. LS (calculated in WL SBCE review) correlation with FC levels was r = 0.490 (P = 0.01), while for BM review and LS correlation with FC was r = 0.472 (P = 0.013). | Anastasios Koulaouzidis Sarah Douglas John N Plevris | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，2： | 3 |
| 17 | Liver Transplantation Criteria For Hepatocellular Carcinoma Should Be Expanded: A 22-Year Experience With 467 Patients at UCLA显示文摘 | John P. Duffy Andrew Vardanian Elizabeth Benjamin Melissa Watson Douglas G. Farmer Rafik M. Ghobrial Gerald Lipshutz Hasan Yersiz David S. K. Lu Charles Lassman Myron J. Tong Jonathan R. Hiatt Ronald W. Busuttil | 2007 | Annals of Surgery2007，，3： | 3 |
| 18 | Reinterpretation of histology of proximal colon polyps called hyperplastic in 2001显示文摘AIM: To evaluate how proximal colon polyps interpreted as hyperplastic polyps in 2001 would be interpreted by expert pathologists in 2007. METHODS: Forty consecutive proximal colon polyps ≥ 5 mm in size, removed in 2001, and originally interpreted as hyperplastic polyps by general pathologists at Indiana University, were reviewed in 2007 by 3 GI pathologists. RESULTS: The gastrointestinal (GI) pathologists interpreted 85%, 43% and 30% of the polyps as sessile serrated polyps (sessile serrated adenomas). The overall Kappa was 0.16. When diagnoses were compared in pairs, Kappa values were 0.38 and 0.25 (fair agreement) and 0.14 (slight agreement). CONCLUSION: Many polyps interpreted as hyperplastic in 2001 were considered sessile serrated lesions by GI pathologists in 2007, but there is substantial inter-observer variation amongst GI pathologists. | Omer Khalid Sofyan Radaideh Oscar W Cummings Michael J O'Brien John R Goldblum Douglas K Rex | 2009 | World Journal of Gastroenterology2009，15，30： | 3 |
| 19 | Descriptive analysis of PM 2.5 and PM 10 at regionally representative locations during SJVAQS/AUSPEX显示文摘 | Judith C. Chow John G. Watson Zhiqiang Lu Douglas H. Lowenthal Clifton A. Frazier Paul A. Solomon Richard H. Thuillier Karen Magliano | 1996 | Atmospheric Environment1996，，12： | 3 |
| 20 | Vascular Complications of Orthotopic Liver Transplantation: Experience in More than 4,200 Patients显示文摘 | John P. Duffy Johnny C. Hong Douglas G. Farmer Rafik M. Ghobrial Hasan Yersiz Jonathan R. Hiatt Ronald W. Busuttil | 2009 | Journal of the American College of Surgeons2009，，5： | 3 |
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