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| 1 | Environment as the Stage for Economic Actors显示文摘The relative importance of economics and environment in debate may soon be reversed due to the influence of three fac- tors. Firstly, in the global economy it is hard to hide the unwanted products of economic processes. Secondly, huge advances in sci- ence will reduce the imperfect knowledge of markets, making some monitoring and analyzing tools show the design of sensible and equitable livelihood in communities, which is more important than the motivation of maximising profits for some individuals or firms. Thirdly, China, as the last major player on the planet to take on economic growth, comes from traditions fundamentally differ- ent from those economies that have experienced the Industrial Revolution previously. Its challenges with sustainability and en- vironmental conservation predate Western economics by millennia, and it is implementing policies domestically and starting to work on the world stage that acknowledges that the surroundings are the host for any economic and socio-political system. | John E Coulter Shi Lei Samantha Jenkins | 2007 | Chinese Journal of Population,Resources and Environment2007，5，1： | 10 |
| 2 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 3 | Tetracycline-inducible protein expression in pancreatic cancer cells: Effects of CapG overexpression显示文摘AIM: To establish stable tetracycline-inducible pancreatic cancer cell lines. METHODS: Suit-2, MiaPaca-2, and Panc-1 cells were transfected with a second generation reverse tetracycline-controlled transactivator protein (rtTA2S-M2), under the control of either a cytomegalovirus (CMV) or a chicken β-actin promoter, and the resulting clones were characterised.RESULTS: Use of the chicken (β-actin) promoter proved superior for both the production and maintenance of doxycycline-inducible cell lines. The system proved versatile, enabling transient inducible expression of a variety of genes, including GST-P, CYP2E1, S100A6, and the actin capping protein, CapG. To determine the physiological utility of this system in pancreatic cancer cells, stable inducible CapG expressors were established. Overexpressed CapG was localised to the cytoplasm and the nuclear membrane, but was not observed in the nucleus. High CapG levels were associated with enhanced motility, but not with changes to the cell cycle, or cellular proliferation. In CapG-overexpressing cells, the levels and phosphorylation status of other actin-moduating proteins (Cofilin and Ezrin/Radixin) were not altered. However, preliminary analyses suggest that the levels of other cellular proteins, such as ornithine aminotransferase and enolase, are altered upon CapG induction. CONCLUSION: We have generated pancreatic-cancer derived cell lines in which gene expression is fully controllable. | Sarah Tonack Sabina Patel Mehdi Jalali Taoufik Nedjadi Rosalind E Jenkins Christopher Goldring John Neoptolemos Eithne Costello | 2011 | World Journal of Gastroenterology2011，17，15： | 4 |
| 4 | Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype显示文摘AIM To identify whether Cp G island methylator phenotype(CIMP) is predictive of response to neoadjuvant chemoradiotherapy(NACRT) and outcomes in rectal cancer.METHODS Patients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status(high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined uponhistological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed.RESULTS There were 160 patients analysed with a median followup time of 46.4 mo. Twenty-one(13%) patients demonstrated high levels of CIMP methylation(CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion(EMVI) compared with CIMP-L [8/21(38%) vs 15/99(15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival(P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation(P = 0.01). There were 14(9%) patients with a pathological complete response(pC R) compared to 116(73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pC R had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant(P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced 'T' stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurrence.CONCLUSION We report a novel association of pre-treatment characterisation of CIMP-H with EMVI status which has prognostic implications and is not readily detectable on pre-treatment histological examination. | Jeremy Stuart Williamson Huw Geraint Jones Namor Williams Anthony Paul Griffiths Gareth Jenkins John Beynon Dean Anthony Harris | 2017 | World Journal of Gastrointestinal Oncology2017，9，5： | 4 |
| 5 | Healing of duodenal ulcer after eradication of Helicobacter heilmannii显示文摘 | Andrew F Goddard Robert PH Logan John C Atherton David Jenkins Robin C Spiller | 1997 | The Lancet1997，，9068： | 2 |
| 6 | Particulate matter at a rural location in southern England during 2006: Model sensitivities to precursor emissions显示文摘 | Richard Derwent Claire Witham Alison Redington Michael Jenkin John Stedman Rachel Yardley Garry Hayman | 2008 | Atmospheric Environment2008，，3： | 1 |
| 7 | Adrenal Insufficiency, Heart Rate Variability, and Complex Biologic Systems: A Study of 1,871 Critically Ill Trauma Patients显示文摘 | John A. Morris Patrick R. Norris Lemuel R. Waitman Asli Ozdas Oscar D. Guillamondegui Judith M. Jenkins | 2007 | Journal of the American College of Surgeons2007，，5： | 1 |
| 8 | Laying the Cytotaxonomic Foundations of a New Model Grass, Brachypodium distachyon (L.) Beauv.显示文摘 | Robert Hasterok John Draper Glyn Jenkins | 2004 | Chromosome Research2004，，4： | 1 |
| 9 | A COMPARISON OF CYTOLOGY AND FLUORESCENCE IN SITU HYBRIDIZATION FOR THE DETECTION OF UROTHELIAL CARCINOMA显示文摘 | KEVIN C. HALLING WALTER KING IRINA A. SOKOLOVA REID G. MEYER HALEH M. BURKHARDT AMY C. HALLING JOHN C. CHEVILLE THOMAS J. SEBO SANJAY RAMAKUMAR CHRISTOPHER S. STEWART SHANE PANKRATZ DENNIS J. O’KANE STEVEN A. SEELIG MICHAEL M. LIEBER ROBERT B. JENKINS | 2000 | The Journal of Urology2000，，5： | 1 |
| 10 | Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update显示文摘 | Antonio C. Wolff M. Elizabeth H. Hammond David G. Hicks Mitch Dowsett Lisa M. McShane Kimberly H. Allison Donald C. Allred John M.S. Bartlett Michael Bilous Patrick Fitzgibbons Wedad Hanna Robert B. Jenkins Pamela B. Mangu Soonmyung Paik Edith A. Perez Mi | 2013 | Journal of Clinical Oncology2013，，： | 1 |
| 11 | 阿司匹林诱发哮喘的流行情况:系统性综述及临床意义显示文摘目的 对阿司匹林诱发哮喘流行情况及相关综合征进行再评估。 资料来源 以下数据库:Biosis,SciSearch(1990-2002年3月),Embase(1974-2002年3月),Medline(1966-2002年3月),Toxline,Derwent DrugFile(1964-2002年3月),学术会议论文索引,国际药学摘要,药学在线(1978-2002年3月)。 选择标准 研究类型,患者人群,评价结果的方法。综述仅限于非处方止痛剂的呼吸道反应。 结果 与文献记载的阿司匹林诱发哮喘的发生率(成人3%,95%可信区间2%-4%,儿童2%,1%-3%)相比,口服激发试验的阳性率(成人21%,14%-29%,儿童5%,0-4%)最高。大多数阿司匹林诱发哮喘患者对非处方非甾体抗炎药(NSAIDs)存在着交叉过敏:布洛芬,98%;萘普生,100%;双氯芬酸,93%。而只有7%的人对扑热息痛交叉过敏。 结论 成人阿司匹林诱发哮喘的患病率比过去提出的要高。因此,当临床需要应用阿司匹林或某种非甾体抗炎药(NSAIDs)而不能肯定其安全性时,应做口服激发试验。 | Christine Jenkins John Costello Linda Hodge 满晓燕 黄克武 | 2004 | 英国医学杂志中文版2004，7，4： | 1 |
| 12 | Retirement and Housing Adjustment in Later Life:Evidence from the British Household Panel显示文摘 | JENKINS P Stephen | 1999 | Labour Economics1999，，6： | 1 |
| 13 | Endovascular Stenting for Vertebral Artery Stenosis显示文摘 | J. Stephen Jenkins Samir N. Patel Christopher J. White Tyrone J. Collins John P. Reilly Paul W. McMullan Mark A. Grise Arthur G. Grant Stephen R. Ramee | 2010 | Journal of the American College of Cardiology2010，，6： | 1 |
| 14 | The knowns, known unknowns and unknowns of sequestration of soil organic carbon显示文摘 | Uta Stockmann Mark A. Adams John W. Crawford Damien J. Field Nilusha Henakaarchchi Meaghan Jenkins Budiman Minasny Alex B. McBratney Vivien de Remy de Courcelles Kanika Singh Ichsani Wheeler Lynette Abbott Denis A. Angers Jeffrey Baldock Michael Bird Phil | 2013 | Agriculture Ecosystems and Environment2013，，： | 1 |
| 15 | The Emerging Role of Neutrophil to Lymphocyte Ratio in Determining Colorectal Cancer Treatment Outcomes: A Systematic Review and Meta-Analysis显示文摘 | George Malietzis Marco Giacometti Robin H. Kennedy Thanos Athanasiou Omer Aziz John T. Jenkins | 2014 | Annals of Surgical Oncology2014，，12： | 1 |
| 16 | Curcumin abrogates bile-induced NF-κB activity and DNA damage in vitro and suppresses NF-κB activity whilst promoting apoptosis in vivo, suggesting chemopreventative potential in Barrett’s oesophagus显示文摘 | Nihit Rawat Ali Alhamdani Elizabeth McAdam James Cronin Zak Eltahir Paul Lewis Paul Griffiths John N. Baxter Gareth J. S. Jenkins | 2012 | Clinical and Translational Oncology2012，，4： | 1 |
| 17 | Decentralizing high school administration in Detroit: an evaluation of alternative strategies of political control显示文摘 | Michael A Jenkins John W Shepherd | 1972 | Economic Geography1972，48，1： | 1 |
| 18 | Screening participation for people at increased risk of colorectal cancer due to family history: a systematic review and meta-analysis显示文摘 | Driss Ait Ouakrim Trevor Lockett Alex Boussioutas John L. Hopper Mark A. Jenkins | 2013 | Familial Cancer2013，，3： | 1 |
| 19 | Human herpesvirus 8 seroconversion in a population‐based cohort of men in Tobago显示文摘 | Alicia C. McDonald Frank J. Jenkins Clareann H. Bunker John W. Wilson Alan L. Patrick Joel L. Weissfeld | 2015 | J. Med. Virol2015，，： | 1 |
| 20 | Inguinal hernias显示文摘 | John T Jenkins Patrick J O'Dwyer | 2008 | BMJ2008，336，7638： | 1 |
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