|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 评估大气细颗粒物暴露引起的全球疾病负担的一个综合风险函数显示文摘[背景]评估由于环境空气中细颗粒物(PM2.5)长期暴露引起的疾病负担,需要了解相对风险度(RR)函数的图形和幅度。然而,在世界上很多观察到高PM2.5环境浓度的地方,都缺乏足够的直接证据确定死亡RR函数的图形。[目的]建立可用于全球PM2.5暴露范围内成人死因的RR函数:缺血性心脏病(IHD)、脑血管疾病(脑卒中)、慢性阻塞性肺病(COPD)和肺癌(LC)。建立急性下呼吸道感染(ALRI)发病的RR函数,用于估算〈5岁的儿童中死亡率和健康生活损失年数。[方法]通过整合现有的来自于环境空气污染(AAP)、二手烟草烟雾、家用固体烹饪用燃料和主动吸烟(AS)等研究的RR信息,拟合综合暴露-反应(IER)模型。采用颗粒物质的吸入剂量,通过转化AS暴露来估计全年PM2.5的暴露当量。在估算全球环境PM2.5浓度的基础上,得出各国的人群归因分数(PAFs)。[结果]与以往负担评估中使用的其他7种模型相比,IER模型是一种优越的RR预测方法。在不同国家中,归因于AAP暴露的PAF百分数各不相同,分别为:IHD,2~41;脑卒中,1~43;COPD,〈1~21;LC,〈1~25;ALRI,〈1~38。[结论]我们建立了一种以细颗粒物为基础的RR模型,它通过整合来自不同类型的燃烧所产生颗粒物排放的RR信息,涵盖全球范围的暴露。当获得新的RR信息时,可以对这个模型进行更新。 | Richard T.Burnett C.Arden Pope III Majid Ezzati Casey Olives Stephen S.Lim Sumi Mehta Hwashin H.Shin Gitanjali Singh Bryan Hubbell Michael Brauer H.Ross Anderson Kirk R.Smith John R.Balmes Nigel G.Bruce Haidong Kan Francine Laden Annette Prüss-Ustün Michelle C.Turner Susan M.Gapstur W.Ryan Diver Aaron Cohen 何蓉 张伊人 金泰廙 | 2014 | 环境与职业医学2014，31，11： | 80 |
| 2 | Metabolomic Profiling in Selaginella lepidophylla at Various Hydration States Provides New Insights into the Mechanistic Basis of Desiccation Tolerance显示文摘Selaginella lepidophylla 是仅仅一些之一发展了干燥忍耐(DT ) 或从一个 air-dried 状态复兴的能力的尖铁苔藓(Selaginellaceae ) 的种类。以便理解 DT 的新陈代谢的基础, S。lepidophylla 受到一五阶段, rehydration/dehydration 周期,然后分析了使用基于 GC/MS 和 UHLC/MS/MS2 平台介绍技术的非偏导的、全球 metabolomics。包括 167 说出的 251 代谢物(66.5%) 的一个总数并且 84 (33.4%) 未命名的混合物被描绘。仅仅 42 (16.7%) 并且(29.5%) 74 混合物显示出显著地增加或减少的丰富分别地,显示大多数混合物组成地被生产包括高度丰富的 trehalose,蔗糖,和葡萄糖。几 glycolysis/gluconeogenesis 和 tricarboxylic 酸(TCA ) 周期中介在 100% 亲戚水内容(RWC ) 和 50% RWC 显示出增加的丰富。Vanillate,一种有势力抗氧化剂,也更充满含水的状态。许多不同的糖白酒和糖酸更充满含水的状态。这些 polyols 多半速度率在水和期间在弄干的过程以及慢水吸收期间浇损失,稳定蛋白质,并且清除反应的氧种类(ROS ) 。相反,充满氮并且 -glutamyl 氨基酸,瓜氨酸,和核苷酸分解代谢产品(例如 allantoin ) 更充满干燥状态,建议这些混合物可能在水和期间或在清除的 ROS 在氮动员起重要作用。紫外保护的混合物象 3-(3-hydroxyphenyl ) 那样 propionate, apigenin,和 naringenin,更充满干燥状态。大多数类脂化合物组成地被生产,与胆碱磷酸盐的例外,它更充满干燥状态并且多半在膜水和和稳定起一个作用。相反,几多元不堡和丰满的酸更充满含水的状态,建议这些混合物多半帮助在脱水期间维持膜流动性。最后, S。lepidophylla 包含了显示了双重或更大的丰富在的七未命名的混合物干燥或 rehydrating 状态,建议这些混合物可能在 DT 起适应作用。 | Abou Yobi Bernard W.M. Wone Wenxin Xu Danny C. Alexander Lining Guo John A. Ryals Melvin J. Oliver John C. Cushman | 2013 | Molecular Plant2013，6，2： | 9 |
| 3 | Upper gastrointestinal bleeding in Scotland 2000-2010: Improved outcomes but a significant weekend effect显示文摘AIM: To assess numbers and case fatality of patients with upper gastrointestinal bleeding(UGIB),effects of deprivation and whether weekend presentation affected outcomes.METHODS: Data was obtained from Information Services Division(ISD) Scotland and National Records of Scotland(NRS) death records for a ten year period between 2000-2001 and 2009-2010. We obtained data from the ISD Scottish Morbidity Records(SMR01) database which holds data on inpatient and daycase hospital discharges from non-obstetric and nonpsychiatric hospitals in Scotland. The mortality data was obtained from NRS and linked with the ISD SMR01 database to obtain 30-d case fatality. We used 23 ICD-10(International Classification of diseases) codes which identify UGIB to interrogate database. We analysed these data for trends in number of hospital admissions with UGIB,30-d mortality over time and assessed effects of social deprivation. We compared weekend and weekday admissions for differences in 30-d mortality and length of hospital stay. We determined comorbidities for each admission to establish if comorbidities contributed to patient outcome. RESULTS: A total of 60643 Scottish residents were admitted with UGIH during January,2000 and October,2009. There was no significant change in annual number of admissions over time,but there was a statistically significant reduction in 30-d case fatality from 10.3% to 8.8%(P < 0.001) over these 10 years. Number of admissions with UGIB was higher for the patients from most deprived category(P < 0.05),although case fatality was higher for the patients from the least deprived category(P < 0.05). There was no statistically significant change in this trend between 2000/01-2009/10. Patients admitted with UGIB at weekends had higher 30-d case fatality compared with those admitted on weekdays(P < 0.001). Thirty day mortality remained significantly higher for patients admitted with UGIB at weekends after adjusting for comorbidities. Length of hospital stay was also higher overall for patients admitted at the weekend when compared to weekdays,although only reached statistical significance for the last year of study 2009/10(P < 0.0005). CONCLUSION: Despite reduction in mortality for UGIB in Scotland during 2000-2010,weekend admissions show a consistently higher mortality and greater lengths of stay compared with weekdays. | Asma Ahmed Matthew Armstrong Ishbel Robertson Allan John Morris Oliver Blatchford Adrian J Stanley | 2015 | World Journal of Gastroenterology2015，21，38： | 4 |
| 4 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 5 | 学习设计的处方显示文摘本文主要描述了一种研究活动,此项活动由参与澳洲大学教育委员会“AUTC”资助项目的研究者负责的。AUTC资助的项目为信息和传播技术及其在弹性学习中的作用。此项目旨在研究和开发通用型学习框架,以便为高等教育提供技术增强型高效能学习经验。鉴于此,研究者一直致力于寻求通用型学习设计的处方,来促进建构知识解决问题。本文总结了所做的各项研究工作,并说明了研究过程中开发的通用学习框架。 | Ron Oliver Barry Harper John Hedberg Sandra Wills Shiriey Agostinho 吴文胜 盛群力 | 2007 | 远程教育杂志2007，25，2： | 3 |
| 6 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 2 |
| 7 | Spontaneous rupture of hepatocellular carcinoma: a Western experience显示文摘 | Narendra Battula Mansoor Madanur Oliver Priest Parthi Srinivasan John O’Grady Michael A. Heneghan Matthew Bowles Paolo Muiesan Nigel Heaton Mohamed Rela | 2009 | The American Journal of Surgery2009，，2： | 2 |
| 8 | Comparison of four scanning mobility particle sizers at the Fresno Supersite显示文摘Size distributions of ambient aerosols at the Fresno Supersite were measured with four commercially available scanning mobility particle sizers(SMPS) . TSI nano,TSI standard,Grimm,and MSP instruments were collocated at the Fresno Supersite and particle size distributions were measured continuously from August 18 through September 18,2005. For particles with diameters between 10 and 200 nm,differences among hourly-average ambient particle concentrations ranged from 0% between the TSI nano and Grimm in the 30-50 nm size range to 39% between the Grimm and MSP in the 10-30 nm size range. MSP concen-trations were 10-33% lower than those measured with the TSI standard for particles smaller than 200 nm. The TSI nano and TSI standard agreed to within 5% in their overlapping size range(10-84 nm) . The TSI nano and Grimm agreed to within 40% for 5-10 nm particles. | John G. Watson Judith C. Chow David A. Sodeman Douglas H. Lowenthal M.-C. Oliver Chang Kihong Park Xiaoliang Wang | 2011 | Particuology2011，9，3： | 2 |
| 9 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 10 | Property Rights and the Nature of the Firm 显示文摘 | Oliver D Hart John Moore | 1990 | Joumal of Political Economy1990，98，6： | 1 |
| 11 | Property Rights and Na- ture of the Firm显示文摘 | Hart Oliver and John Moore | 1990 | Journal of Political Economy1990，，98： | 1 |
| 12 | The Trehalose Myth Revisited: Introduction to a Symposium on Stabilization of Cells in the Dry State显示文摘 | John H. Crowe Lois M. Crowe Ann E. Oliver Nelly Tsvetkova Willem Wolkers Fern Tablin | 2001 | Cryobiology2001，，2： | 1 |
| 13 | The effect of resisted sprint training on maximum sprint kinetics and kinematics in youth显示文摘 | Michael C. Rumpf John B. Cronin Ikhwan N. Mohamad Sharil Mohamad Jon L. Oliver Michael G. Hughes | 2015 | European Journal of Sport Science2015，，： | 1 |
| 14 | Contracts as Reference Points 显示文摘 | OLIVER HART JOHN MOORE | 2008 | Quarterly Journal of Economics2008，123，1： | 1 |
| 15 | Property rights and the nature of the firm 显示文摘 | Oliver Hart John Moore | 1990 | Journal of Political Economy1990，98，6： | 1 |
| 16 | Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension显示文摘 | JOHN S W KREGE J H OLIVER P M | 1995 | Science1995，267，5198： | 1 |
| 17 | Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner显示文摘 | OLIVER P M JOHN S W PURDYK E | 1998 | PNAS1998，95，5： | 1 |
| 18 | Theory of Debt Based on the Inalienability of Human Capital 显示文摘 | Hart Oliver and John Moore | 1994 | Quarterly Journal of Economics1994，，109： | 1 |
| 19 | Diagnosis and Management of Partial Small Bowel Obstruction after Laparoscopic Antecolic Antegastric Roux-en-Y Gastric Bypass for Morbid Obesity显示文摘 | Minyoung Cho Lester Carrodeguas David Pinto Charles Lascano Flavia Soto Oliver Whipple Richard Gordon Conrad Simpfendorfer John Paul Gonzalvo Samuel Szomstein Raul J. Rosenthal | 2006 | Journal of the American College of Surgeons2006，，2： | 1 |
| 20 | Genetic decrea-ses in atrial natriuretic peptide and salt-sensitive hyper-tension显示文摘 | John S W Krege J H Oliver P M | 1995 | Science1995，267，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员