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| 1 | 缺血性卒中的一级预防——美国心脏协会/美国卒中协会卒中委员会指南 动脉粥样硬化性周围血管病跨学科工作组、心血管护理委员会、临床心脏病学委员会、营养、体力活动和代谢委员会以及医疗质量和转归研究跨学科工作组共同倡导显示文摘背景和目的本指南提供有关各种确定和潜在的卒中危险因素证据的概述,并提供降低卒中风险的推荐。方法写作组成员由委员会主席根据每位作者先前在相关课题领域中的工作提名,并经美国心脏协会(AHA)卒中委员会科学声明监督委员会批准。写作组采用系统文献回顾(涵盖时间段为2001年最后一次回顾发表到2005年1月),参考先前已发表的指南、个人文件和专家意见来概括现有的证据,指明现有知识的差距;如果合适,则根据标准的AHA标准做出简明的推荐。写作组全体成员在撰写过程中均有很多机会对推荐进行评论并认可这份声明的最终版本。在AHA科学咨询与协调委员会批准之前,本指南已进行过广泛的同行评议。结果对评价个体首次卒中风险的流程图进行评估。根据干预的可能性(不可干预、可干预或潜在可干预)和证据的强度(证据充分或证据不太充分),对首次卒中的危险因素或风险标记物进行分类。不可干预的危险因素包括年龄、性别、出生体重低、人种/种族和遗传因素。证据充分的可干预危险因素包括高血压、主动或被动吸烟、糖尿病、心房颤动和某些其他心脏病、血脂异常、颈动脉狭窄、镰状细胞病、绝经后激素治疗、不良饮食习惯、缺乏体力活动、肥胖和体脂分布。证据不太充分或潜在的可干预危险因素包括代谢综合征、酗酒、药物滥用、口服避孕药、睡眠呼吸障碍、偏头痛、高同型半胱氨酸血症、脂蛋白(a)升高、脂蛋白相关的磷脂酶升高、高凝状态、炎症和感染。对应用阿司匹林进行卒中一级预防的资料进行回顾。结论有大量证据可以用于确定增加首次卒中风险的各种特殊因素和提供降低这种风险的策略。 | Larry B. Goldstein Robert Adams Mark J. Alberts Lawrence J. Appel Lawrence M. Brass Cheryl D. Bushnell Antonio Culebras Thomas J. DeGraba Philip B. Gorelick John R. Guyton Robert G. Hart George Howard Margaret Kelly-Hayes J.V. (Ian) Nixon Ralph L. Sacco 苏克江 高宗恩 | 2006 | 国际脑血管病杂志2006，14，8： | 28 |
| 2 | 动脉瘤性蛛网膜下腔出血处理指南 美国心脏协会卒中委员会特别写作组给医疗专业人员的声明显示文摘蛛网膜下腔出血(subarachnoid hemorrhage,SAH)是一种常见病,常常导致严重后果,约占全部卒中病例的5%,在美国每年有多达3万人罹患该病。美国心脏协会(American Heart Association,AHA)曾发表过“动脉瘤性SAH处理指南”。此后,在血管内技术、诊断方法以及手术和围手术期管理方面已取得了显著进展。尽管如此,SAH患者的预后依然较差,基于人群研究报告的病死率高达45%,并且存活者会遗留严重残疾。一些多中心前瞻性随机试验和前瞻性队列分析已对SAH的治疗方案产生影响。然而, | Joshua B. Bederson E. Sander Connolly H. Hunt Batjer Ralph G. Dacey Jacques E. Dion Michael N. Diringer John E. Duldner Robert E. Harbaugh Aman B. Patel Robert H. Rosenwasser 高翔(译) 李洛(译) 李海峰(译) | 2009 | 国际脑血管病杂志2009，17，4： | 24 |
| 3 | 1423 Pancreaticoduodenectomies for Pancreatic Cancer: A Single-Institution Experience显示文摘 | Jordan M. Winter John L. Cameron Kurtis A. Campbell Meghan A. Arnold David C. Chang JoAnn Coleman Mary B. Hodgin Patricia K. Sauter Ralph H. Hruban Taylor S. Riall Richard D. Schulick Michael A. Choti Keith D. Lillemoe Charles J. Yeo | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 5 |
| 4 | Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage: A Statement for Healthcare Professionals From a Special Writing Group of the Stroke Council, American Heart Association显示文摘 | Joshua B. Bederson E Sander Connolly H Hunt Batjer Ralph G. Dacey Jacques E. Dion Michael N. Diringer John E. Duldner Robert E. Harbaugh Aman B. Patel Robert H. Rosenwasser | 2009 | Stroke2009，，3： | 4 |
| 5 | Common amino acid sequence domains among the LEA proteins of higher plants显示文摘 | Leon Dure Martha Crouch John Harada Tuan-Hua David Ho John Mundy Ralph Quatrano Terry Thomas Z. R. Sung | 1989 | Plant Molecular Biology1989，，5： | 3 |
| 6 | Prognostic relevance of lymph node ratio following pancreaticoduodenectomy for pancreatic cancer显示文摘 | Timothy M. Pawlik Ana L. Gleisner John L. Cameron Jordan M. Winter Lia Assumpcao Keith D. Lillemoe Christopher Wolfgang Ralph H. Hruban Richard D. Schulick Charles J. Yeo Michael A. Choti | 2007 | Surgery2007，，5： | 3 |
| 7 | Cholangiocarcinoma: A Spectrum of Intrahepatic, Perihilar, and Distal Tumors显示文摘 | Attila Nakeeb Henry A. Pitt Taylor A. Sohn JoAnn Coleman Ross A. Abrams Steven Piantadosi Ralph H. Hruban Keith D. Lillemoe Charles J. Yeo John L. Cameron | 1996 | Annals of Surgery1996，，4： | 3 |
| 8 | Solid-Pseudopapillary Tumors of the Pancreas Are Genetically Distinct from Pancreatic Ductal Adenocarcinomas and Almost Always Harbor β -catenin Mutations显示文摘 | Susan C. Abraham David S. Klimstra Robb E. Wilentz Charles J. Yeo Kevin Conlon Murray Brennan John L. Cameron Tsung-Teh Wu Ralph H. Hruban | 2002 | The American Journal of Pathology2002，，4： | 2 |
| 9 | A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma: A Phase II Trial of Safety, Efficacy, and Immune Activation显示文摘 | Lutz Eric Charles J. Yeo Keith D. Lillemoe Barbara Biedrzycki Barry Kobrin Joseph Herman Elizabeth Sugar Steven Piantadosi John L. Cameron Sara Solt Beth Onners Irena Tartakovsky Miri Choi Rajni Sharma Peter B. Illei Hruban Ralph H. Ross A. Abrams Dung Le | 2011 | Annals of Surgery2011，，2： | 2 |
| 10 | 1423 pancreaticoduodenectomies for pancreatic cancer: A single-institution experience显示文摘 | Jordan M. Winter M.D. John L. Cameron M.D. Kurtis A. Campbell M.D. Meghan A. Arnold M.D. David C. Chang Ph.D. M.B.A. M.P.H. JoAnn Coleman C.R.N.P. Mary B. Hodgin C.M.S.R.N. Patricia K. Sauter C.R.N.P. Ralph H. Hruban M.D. Taylor S. Riall M.D. Richard D. | 2006 | Journal of Gastrointestinal Surgery2006，，9： | 2 |
| 11 | Frequent Detection of Pancreatic Lesions in Asymptomatic High-Risk Individuals显示文摘 | Marcia Irene Canto Ralph H. Hruban Elliot K. Fishman Ihab R. Kamel Richard Schulick Zhe Zhang Mark Topazian Naoki Takahashi Joel Fletcher Gloria Petersen Alison P. Klein Jennifer Axilbund Constance Griffin Sapna Syngal John R. Saltzman Koenraad J. Mortele | 2012 | Gastroenterology2012，，4： | 2 |
| 12 | NSAID celecoxib: a potent mitochondrial pro-oxidant cytotoxic agent sensitizing metastatic cancers and cancer stem cells to chemotherapy显示文摘Intermittent hypoxia within tumor microenvironments causes pro-oxidative stress impairing oxidative phos-phorylation(OxPhos)and increases mitochondrial production of reactive oxygen species(ROS).In primary tu-mors this provokes metabolic reprogramming of both tumor cells and cancer stem cells and emergence of highly metastatic cancer cells.Tumor reprogramming is initiated by activating nuclear respiratory factors and hypoxia-inducible factors in response to changes in oxygen and ROS levels.Hence,hypoxia-induced pro-oxidative stress drives invasion and metastasis.However,it is also the Achilles’heel of metastatic cancer cells because pro-oxi-dative agents further overload the mitochondria and intracellular milieu with excessive ROS to trigger apoptosis,whereas antioxidant agents promote their survival and tumor progression.Herein lies the metastatic tumor cell sensitivity to non-steroidal anti-inflammatory drugs(NSAIDs)and we and others have shown that the NSAID celecoxib exerts powerful pro-oxidative anticancer effects by directly targeting mitochondria to increase ROS production and trigger cancer cell death,including metastatic cancer cells and cancer stem cells.This review highlights the considerable benefits from appropriate NSAID use in humans against post-diagnosis metastatic tumors and the need to further develop their use as adjuvant therapy for advanced stage metastatic disease where they are already showing significantly improved clinical outcomes. | Stephen John Ralph Sam Nozuhur Rafael Moreno-Sanchez Sara Rodriguez-Enriquez Rhys Pritchard | 2018 | Journal of Cancer Metastasis and Treatment2018，4，1： | 2 |
| 13 | Six Hundred Fifty Consecutive Pancreaticoduodenectomies in the 1990s: Pathology, Complications, and Outcomes显示文摘 | Charles J. Yeo John L. Cameron Taylor A. Sohn Keith D. Lillemoe Henry A. Pitt Mark A. Talamini Ralph H. Hruban Sarah E. Ord Patricia K. Sauter JoAnn Coleman Marianna L. Zahurak Louise B. Grochow Ross A. Abrams | 1997 | Annals of Surgery1997，，3： | 2 |
| 14 | 阴茎再造术最新进展显示文摘阴茎再造术对泌尿外科医生来说仍是一个巨大的挑战。本文综述了创伤后阴茎再造、良性和恶性疾病的阴茎切除、小阴茎病人、aphallia病人、女变男性别焦虑症病人方面的最新进展。 | Giulio Garaffa Amr Abdel Raheem David John Ralph | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 15 | Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinomad—part 3: Update on 5-year survival显示文摘 | Taylor S. Riall M.D. John L. Cameron M.D. Keith D. Lillemoe M.D. Kurtis A. Campbell M.D. Patricia K. Sauter C.R.N.P. JoAnn Coleman C.R.N.P. Ross A. Abrams M.D. Daniel Laheru M.D. Ralph H. Hruban M.D. Charles J. Yeo M.D | 2005 | Journal of Gastrointestinal Surgery2005，，9： | 2 |
| 16 | Apparent diffusion coefficient from magnetic resonance imaging as a biomarker in oncology drug development显示文摘 | Ralph Sinkus Bernard E. Van Beers Valérie Vilgrain Nandita DeSouza John C. Waterton | 2011 | European Journal of Cancer2011，，4： | 2 |
| 17 | Yohimbine in the treatment of orgasmic dysfunction显示文摘瞄准:与高潮的机能障碍在人的治疗学习育亨宾硷的效果。方法:育亨宾硷的 A 20-mg 剂量首先在诊所与不同原因论的高潮的机能障碍被给 29 个人。病人们然后被允许在更赞成的情形下面在家(滴定) 增加剂量。结果和副作用随后被估计。结果:病人被分类进三组高潮的机能障碍:主要完全(13 ) ,主要不完全(8 ) 并且第二等(8 ) 。梦遗在 75%,40% 是在场的,在上面的 50% 病人组织,分别地(总的来说平均 62%) 。因为富饶问题(52%) ,介绍的人或因为他们想要经历高潮(48%) 的快乐。完成了治疗的 29 个病人, 16 设法到达高潮并且也在手淫或性交期间是有能力的脚趾投掷。进一步,三完成了的 A 达到高潮,但是仅仅与一个震荡器的另外的刺激。前面的梦遗的历史在高潮在被劝诱的 69% 人是在场的但是仅仅 50% 没有通过治疗。病人,二随后生了孩子(双胞胎的一个集合) , 3 个人也是的另外一个治好。副作用不是足够的引起这些人停止治疗。结论:Yohimbineis 在高潮的机能障碍的一种有用治疗选择。 | Ade A. Adeniyi Giles S. Brindley John P. Pryor David J. Ralph | 2007 | Asian Journal of Andrology2007，9，3： | 2 |
| 18 | Resected adenocarcinoma of the pancreas—616 patients: results, outcomes, and prognostic indicators显示文摘 | Taylor A. Sohn Charles J. Yeo John L. Cameron Leonidas Koniaris Sunjay Kaushal Ross A. Abrams Patricia K. Sauter JoAnn Coleman Ralph H. Hruban Keith D. Lillemoe | 2000 | Journal of Gastrointestinal Surgery2000，，6： | 2 |
| 19 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 20 | Desulfurization of jet fuel by π-complexation adsorption with metal halides supported on MCM-41 and SBA-15 mesoporous materials显示文摘 | Yuhe W Ralph T Y John M | 2007 | Chemical engineering science2007，52，3： | 1 |
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