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| 1 | Treatment of gastric cancer显示文摘The authors focused on the current surgical treatment of resectable gastric cancer,and significance of periand post-operative chemo or chemoradiation.Gastric cancer is the 4thmost commonly diagnosed cancer and the second leading cause of cancer death worldwide.Surgery remains the only curative therapy,while perioperative and adjuvant chemotherapy,as well as chemoradiation,can improve outcome of resectable gastric cancer with extended lymph node dissection.More than half of radically resected gastric cancer patients relapse locally or with distant metastases,or receive the diagnosis of gastric cancer when tumor is disseminated;therefore,median survival rarely exceeds12 mo,and 5-years survival is less than 10%.Cisplatin and fluoropyrimidine-based chemotherapy,with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients,is the widely used treatment in stageⅣpatients fit for chemotherapy.Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance | Michele Orditura Gennaro Galizia Vincenzo Sforza Valentina Gambardella Alessio Fabozzi Maria Maddalena Laterza Francesca Andreozzi Jole Ventriglia Beatrice Savastano Andrea Mabilia Eva Lieto Fortunato Ciardiello Ferdinando De Vita | 2014 | World Journal of Gastroenterology2014，20，7： | 116 |
| 2 | 光学相干断层成像与组织形态学检测猴青光眼视网膜神经纤维层厚度的比较显示文摘目的 应用光学相干断层成像术 (opticalcoherencetomography ,OCT)检测活体青光眼视网膜神经纤维层 (retinalnervefiberlayer,RNFL)厚度 ,并与组织形态学检测结果进行比较。方法 选用Cynomolgus猴 4只眼 ,通过氩激光烧灼小梁网 ,引起眼压升高 ,制作成青光眼动物模型。应用OCT测量视盘周围直径 ,选取直径为 2 4mmRNFL厚度的猴眼进行研究。在完成最后一次OCT测量后 ,将眼球摘除。摘除的眼球置于 10 %甲醛液中固定 ,石蜡包埋做连续切片及HE染色。应用与光学显微镜相联接的计算机图像处理系统 ,测量与OCT扫描相对应点的组织学切片的RNFL厚度。结果 OCT测量RNFL平均厚度为 (72 2± 5 4 5 ) μm ;组织形态学测量RNFL平均厚度为 (70 3± 5 1 1) μm ,未经校正的组织形态学测量平均厚度为 (6 1 1± 44 2 ) μm。两种检测结果差异无显著性(t=1 895 ,P>0 0 5 )。结论 OCT活体测量RNFL的平均厚度与组织形态学测量结果基本相同 ,但OCT活体测量RNFL厚度值与经校正后的组织形态学测量结果更接近。 | 黄丽娜 Joles Schuman Nan Wang | 2001 | 中华眼科杂志2001，37，3： | 34 |
| 3 | Clinical management of advanced gastric cancer: The role of new molecular drugs显示文摘Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States.Surgery represents the main approach for this disease but,notwithstanding the advances in surgical techniques,we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates.Despite the development of new drugs has significantly improved the effectiveness of chemothera-py,the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor.Recently,several molecular target agents have been investigated;in particular,trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients.New molecules targeting vascular epithelial growth factor,mammalian target of rapamycin,and anti hepatocyte growth factor-c-Met pathway are also under investigation,with interesting results.Anyway,it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results.In this paper we review the actual'scenario'of targeted treatments,also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma,discussing their efficacy and potential applications in clinical practice. | Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura | 2014 | World Journal of Gastroenterology2014，20，40： | 12 |
| 4 | Early mechanisms of renal injury in hypereholesterolemic or hypertriglyeeridemic rats显示文摘 | Joles JA Kunter U Janssen U | 2000 | J Am Soe Nephrol2000，11，： | 1 |
| 5 | Causes and Consequences of Increased Sympathetic Activity in Renal Disease显示文摘 | Jaap A. Joles Hein A. Koomans | 2004 | Hypertension: Journal of the American Heart Association2004，，4： | 1 |
| 6 | Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice显示文摘 | Roestenberg P van Nieuwenhoven FA Joles JA | 2006 | AmJ Physiol Renal Physiol2006，290，6： | 1 |
| 7 | Early mechanisms of renal injury in hypercholesterolemic or hypertriglyceridemic rats显示文摘 | Joles JA Kunter U Janssen U | 2000 | Am Soc Nephrol2000，11，4： | 1 |
| 8 | The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2 and ED3 显示文摘 | Dijkstra C D Dtipp E A Joling P | 1985 | Immunology1985，54，： | 1 |
| 9 | Early mechanisms of renal injury in hypereholesterolemic or hypertriglycefidemic rats 显示文摘 | Joles JA Kunter U Janssen U | 2000 | J Am Soc Nephrol2000，11，4： | 1 |
| 10 | Ischemia and reactive oxygen species in sympathetic hyperactivity states:a vicious cycle that can be interrupted by renal denervation?显示文摘 | Hubens LE Verloop WL Joles JA | 2013 | Curr Hypertens Rep2013，15，4： | 1 |
| 11 | Haemodynamic influences on kidney oxygenation: clinical implications of integrative physio- logy 显示文摘 | Evans RG Ince C Joles JA | 2013 | Clin Exp Pharmacol Physiol2013，40，2： | 1 |
| 12 | The heterogeneity of mononuclear phagocytes in lymphoid organs:distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1,ED2 and ED3显示文摘 | DIJKSTRA C D D?PP E A JOLING P | 1985 | Immunology1985，54，3： | 1 |
| 13 | Temporal expression profile and distribution pattern indicate a role of connective tissue growth factor (CTGF/CCN-2) in diabetic nephropathy in mice显示文摘 | Roestenberg P van Nieuwenhoven F A Joles J A | 2006 | Am J Physiol Renal Physiol2006，290，6： | 1 |
| 14 | Systemic arterial and venous determinants of renal hemodynamics in congestive heart failure显示文摘 | Braam B Cupples WA Joles JA | 2012 | Heart Fail Rev2012，17，2： | 1 |
| 15 | Temporal expression profile and distribution pattern indi- cate a role of connective tissue growth factor ( CTGF/CCN -2) in diabetic nephropathy in mice 显示文摘 | Rosetenberg P van Nieuwenhoven FA Joles JA | 2006 | Am J Physiol Renal Physiol2006，290，6： | 1 |
| 16 | Aerosol size distributions of polycyclic aromatic hydrocarbons in urban and over-water atmospheres 显示文摘 | John O Jole B | 1999 | Environmental Science and Technology1999，33，： | 1 |
| 17 | Hupoalbuminemia causes high blood viscosity by increasing red cell lysophoephatidylcholine显示文摘 | Joles JA Willekes-Koolschijn N Loomans HA | 1997 | Kidney Int1997，52，： | 1 |
| 18 | Sympathetic hyperactivity in chronic renal failure: a wake-up call显示文摘 | Koomans HA Blankestijn PJ Joles JA | 2004 | J Am Soc Nephrol2004，15，： | 1 |
| 19 | Does a family meetings intervention prevent depression and anxiety in fami- ly caregive of dementia patients? A randomized trial 显示文摘 | Joling KJ Van Marwijk HW Smit F | 2012 | PLoS One2012，7，30： | 1 |
| 20 | Perinatal inhibition of NF-kap-paB has long-term antihypertensive effects in spontaneouslyhypertensive rats 显示文摘 | Koeners MP Braam B Joles JA | 2011 | J Hypertens2011，29，6： | 1 |
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