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| 1 | The genome sequence of the SARS-associated coronavirus显示文摘 | Marra M A Jones S J Astell C R | | 0，，： | 6 |
| 2 | Highly active antiretroviral therapy dysregulates proliferation and differentiation of human pre-adipocytes显示文摘AIM To investigate the mechanism(s) by which potential effects of multi-drug highly-active antiretroviral therapy contributes to lipodystrophy syndrome. METHODS Preadipocytes from healthy donors were assessed for proliferation and differentiation in the presence of nucleoside reverse transcriptase inhibitors(NRTIs), nonnucleoside reverse transcriptase inhibitors(NNRTIs), and protease inhibitors(PIs) individually and in combination. Effects on proliferation were assessed with a 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay and effects on differentiation were assessed from glycerol-3-phosphate dehydrogenase(GPDH) activity and quantitation of Oil Red O staining for intracellular lipid. Data were analyzed with a randomized block ANOVA with post-hoc Fisher's Least Significant Difference test. RESULTS Preadipocyte proliferation was inhibited by a combination of NNRTI + NRTI(14% at 48 h, P < 0.001) and PI + NRTI(19% at 48 h, P < 0.001) with additional suppression when ritonavir(RTV) was added(26% at 48 h). The drug combination of atazanavir(ATV) + RTV + emtricitabine(FTC) + tenofovir(TDF) had the greatest inhibitory effect on proliferation at 48 h. Preadipocyte differentiation was most significantly reduced by the efavirenz + FTC + TDF assessed either by GPDH activity(64%) or lipid accumulation(39%), P < 0.001. Combining NRTIs with a PI(ATV + FTC + TDF) significantly suppressed differentiation(GPDH activity reduced 29%, lipid accumulation reduced by 19%, P < 0.01). This effect was slightly greater when a boosting amount of RTV was added(ATV + FTC + TDF + RTV, P < 0.001). CONCLUSION Although combination antiretroviral therapy is clinically more efficacious than single drug regimens, it also has a much greater inhibitory effect on preadipocyte proliferation and differentiation. | Eyone Jones Pavel Mazirka Margaret A McNurlan Frank Darras Marie C Gelato Giuseppe Caso | 2017 | World Journal of Virology2017，6，3： | 3 |
| 3 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 4 | Storage of hydrogen in single-walled carbon nanotubes显示文摘 | Dillon A C Jones K M Bekkedahl T A | 1997 | Nature1997，386，6623： | 2 |
| 5 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 6 | 欧洲鼻腔鼻窦解剖术语意见书(二)显示文摘2014年,Rhinology刊登了European Position Paper on the Anatomical Terminology of the Internal Nose and Paranasal Sinuses,对于认识鼻科解剖名词具有重要的普及意义。考虑到国内耳鼻喉科医师获取和阅读英文文献的能力有限,但是又急需及时掌握学科领域内解剖名词的表述,我们通过与Rhinology编辑部及作者联系征得同意,翻译而成《欧洲鼻腔鼻窦解剖术语规范意见书》(以下简称《意见书》)。《意见书》中的所有解剖名词同时参考国内《英汉汉英医学分科词典(耳鼻咽喉科学分册)》进行统一,对于《英汉汉英医学分科词典(耳鼻咽喉科学分册)》中没有提及的名词给出了相应的补充。希望《意见书》对国内耳鼻喉科医师掌握并规范应用鼻科名词提供参考。《中国眼耳鼻喉科杂志》从第17卷第2期开始以连载形式刊登《意见书》。 | 王德辉 王德云 于华鹏 孙希才 李晗 刘琢扶 刘全 张焕康 Lund VJ Stammberger H Fokkens WJ Beale T Bernal-Sprekelsen M Eloy P Georgalas C Gerstenberger C Hellings PW Herman P Hosemann WG Jankowski R Jones N Jorissen M Leunig A Onerci M Rimmer J Rombaux P Simmen D Tomazic PV Tschabitscher M Welge-Luessen A | 2017 | 中国眼耳鼻喉科杂志2017，17，3： | 2 |
| 7 | Risk factors for in situ cervical cancer: results from a case-control study显示文摘 | Jones C J Brinimi L A Hamman R F | 1990 | Cancer Res1990，50，12： | 1 |
| 8 | Virus infection expands a biased subset of T ceils that bind tetrameric class I peptide complexes 显示文摘 | COLES R M JONES C M BROOKS A G | 2003 | Eur J Immunol2003，33，6： | 1 |
| 9 | Storage of hydrogen in single-walled carbon nanotubes 显示文摘 | DILLON A C JONES K M BEKKEDAHL T A | 1997 | Nature1997，386，6623： | 1 |
| 10 | Recent developments in inductively coupled plasma magnetic sector multiple collector mass spectrometry 显示文摘 | Halliday A N Lee D C Christensen J N Walder A J Freedman P A Jones C E Hall C M Yi W Teagle D | 1995 | Int J Mass Spec Ion Proc1995，，： | 1 |
| 11 | Comparative wear under four different tribological conditions of acetylene enhanced cross-linked ultra high molecularweight polyethylene显示文摘 | Marrs H Barton D C Jones R A | 1999 | J Mater Sci:Mater Med1999，10，： | 1 |
| 12 | Influence of sorption on the biological utilization of two simple carbon substrates显示文摘 | JONES D L EDWARDS A C | 1998 | Soil Biology & Biochemistry1998，30，： | 1 |
| 13 | Comparison of geochemical indices used for the interpretation of palaeoredox conditions in ancient mudstones 显示文摘 | Jones B Manning D A C | 1994 | Chemical Geology1994，111，： | 1 |
| 14 | Pereutaneous tracheostomy: a 6 yr prospective evaluation of the single tapered dilator technique显示文摘 | DEMPSEY G A GRANT C A JONES T M | 2010 | Br J Anaesth2010，105，6： | 1 |
| 15 | A first global pro-duction,emission,and environmental inventory for perfluorooctane sulfonate显示文摘 | Paul A G Jones K C Sweetman A J | 2009 | Environmental Science&Technology2009，43，2： | 1 |
| 16 | A first global pro-duction,emission,and environmental inventory for perfluorooctane sulfonate显示文摘 | Paul A G Jones K C Sweetman A J | 2009 | Environmental Science&Technology2009，43，2： | 1 |
| 17 | Modelling contra-flow in crowd dynamics DEM simulation 显示文摘 | Smith A James C Jones R | 2009 | Safety Science2009，，47： | 1 |
| 18 | Treatment of proximal humerus fractures with polarus nail fixation 显示文摘 | Agel J Jones C B Sanzone A G | 2004 | J Shoulder Elbow Surg2004，13，2： | 1 |
| 19 | Horizontal slice method for analysis显示文摘 | SHAHGHOLI M FAKHER A JONES C J F P | 2001 | G6otechnique2001，51，10： | 1 |
| 20 | Initial development into a novel technique for manufacturing a long fiber thermoplastic bioabsorbable composite: In-situ polymerization of poly-ε-caprolaetone 显示文摘 | Corden T J Jones I A Rudd C D | 1999 | Composites Part A1999，30，6： | 1 |
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