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| 1 | SIRT3-mediated inhibition of FOS through histone H3 deacetylation prevents cardiac fibrosis and inflammation显示文摘Sirtuin 3(SIRT3)is a deacetylase that modulates proteins that control metabolism and protects against oxidative stress.Modulation of SIRT3 activity has been proposed as a promising therapeutic target for ameliorating metabolic diseases and associated cardiac disturbances.In this study,we investigated the role of SIRT3 in inflammation and fibrosis in the heart using male mice with constitutive and systemic deletion of SIRT3 and human cardiac AC16 cells.SIRT3 knockout mice showed cardiac fibrosis and inflammation that was characterized by augmented transcriptional activity of AP-1.Consistent with this,SIRT3 overexpression in human and neonatal rat cardiomyocytes partially prevented the inflammatory and profibrotic response induced by TNF-α.Notably,these effects were associated with a decrease in the mRNA and protein levels of FOS and the DNA-binding activity of AP-1.Finally,we demonstrated that SIRT3 inhibits FOS transcription through specific histone H3 lysine K27 deacetylation at its promoter.These findings highlight an important function of SIRT3 in mediating the often intricate profibrotic and proinflammatory responses of cardiac cells through the modulation of the FOS/AP-1 pathway.Since fibrosis and inflammation are crucial in the progression of cardiac hypertrophy,heart failure,and diabetic cardiomyopathy,our results point to SIRT3 as a potential target for treating these diseases. | Xavier Palomer MSilvia Román-Azcona Javier Pizarro-Delgado Ana Planavila Francesc Villarroya Brenda Valenzuela-Alcaraz Fátima Crispi Álvaro Sepúlveda-Martínez Irene Miguel-Escalada Jorge Ferrer JFrancisco Nistal Raquel García Mercy MDavidson Emma Barroso Manuel Vázquez-Carrera | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 2 | Timely reperfusion for ST-segment elevation myocardial infarction:Effect of direct transfer to primary angioplasty on time delays and clinical outcomes显示文摘Primary percutaneous coronary intervention(PPCI) is the preferred reperfusion therapy for patients presenting with ST-segment elevation myocardial infarction(STEMI) when it can be performed expeditiously and by experienced operators. In spite of excellent clinical results this technique is associated with longer delays than thrombolysis and this fact may nullify the benefit of selecting this therapeutic option. Several strategies have been proposed to decrease the temporal delays to deliver PPCI. Among them,prehospital diagnosis and direct transfer to the cath lab,by-passing the emergency department of hospitals,has emerged as anattractive way of diminishing delays. The purpose of this review is to address the effect of direct transfer on time delays and clinical events of patients with STEMI treated by PPCI. | Rodrigo Estévez-Loureiro ángela López-Sainz Armo Pérez de Prado Carlos Cuellas Ramón Calvio Santos Norberto Alonso-Orcajo Jorge Salgado Fernández Jose Manuel Vázquez-Rodríguez Maria López-Benito Felipe Fernández-Vázquez | 2014 | World Journal of Cardiology2014，6，6： | 6 |
| 3 | Influence of proton pump inhibitors in the development of spontaneous bacterial peritonitis显示文摘AIM To investigate whether the use of proton pump inhibitors(PPIs) increases the incidence of spontaneous bacterial peritonitis(SBP) in patients with cirrhosis and ascites.METHODS An historical cohort study was carried out in cirrhotic outpatients with ascites followed in a specialized clinic at a tertiary hospital in Southern Brazil. Patient charts were reviewed to collect information on the variables of interest as the use of PPIs. Primary outcome was defined as development of SBP during the study period. SBP was diagnosed based on ascitic fluid polymorphonuclear cell count ≥ 250 cells/mm3 without evidence of an intraabdominal, surgically treatable source of infection.RESULTS Of 738 cirrhotic patients, 582(58.2% male) were enrolled, with mean age of 53.6 ± 12 years. Hepatitis C virus infection(36.2%) and alcohol abuse(25.6%) were the main etiologies of cirrhosis. The presence of ascites was detected in 299(51.4%) patients during the development of the study. Nineteen patients with previous diagnosis of SBP undergoing secondary prophylaxis and 22 patients with insufficient PPI data were further excluded. Of 258 patients with ascites, 151 used PPIs, and 34 developed SBP(22.5%). Among 107 non-users of PPIs, 23 developed SBP(21.5%)(HR = 1.44, 95%CI: 0.85-2.47, P = 0.176). The median follow-up time of patients using PPI was 27 mo vs 32 mo for non-users. Univariate analysis of the risk factors associated with the development of SBP revealed a significant association of SPB with the severity of liver disease according to the Child-Turcotte-Pugh(CTP) score. Multivariate analysis confirmed that CTP score was the only independent variable influencing the occurrence of SBP. Survival at 60 mo(Kaplan-Meier analysis) was similar in users and non-users of PPI, independently of the presence of SBP(58.4% vs 62.7% respectively, P = 0.66). For patients with SBP, survival at 60 mo was 55.1%, vs 61.7% in patients without SBP(P = 0.34). CONCLUSION In conclusion, the rate of SBP was not significantly different in users or non-users of PPIs in this cohort of cirrhotic with ascites. | Suelen A S Miozzo Jorge A John Marcelo C Appel-da-Silva Isabella A Dossin Cristiane V Tovo Angelo A Mattos | 2017 | World Journal of Hepatology2017，9，35： | 5 |
| 4 | New approaches for precise response evaluation in hepatocellular carcinoma显示文摘With the increasing clinical use of cytostatic and novel biologic targeted agents,conventional morphologic tumor burden assessments,including World Health Organization criteria and Response Evaluation Criteria in Solid Tumors,are confronting limitations because of their difficulties in distinguishing viable tumor from necrotic or fibrotic tissue.Therefore,the investigation for reliable quantitative biomarkers of therapeutic response such as metabolic imaging or functional imaging has been desired.In this review,we will discuss the conventional and new approaches to assess tumor burden.Since targeted therapy or locoregional therapies can induce biological changes much earlier than morphological changes,these functional tumor burden analyses are very promising.However,some of them have not gone thorough all steps for standardization and validation.Nevertheless,these new techniques and criteria will play an important role in the cancer management,and provide each patient more tailored therapy. | Koichi Hayano Jorge M Fuentes-Orrego Dushyant V Sahani | 2014 | World Journal of Gastroenterology2014，20，12： | 4 |
| 5 | Imaging electron wave functions of quantized energy levels in carbon nanotubes 显示文摘 | LIESBETH C V JEROEN W G JORG W J | 1999 | Science1999，283，： | 1 |
| 6 | Self-cleaning test of doped TiO2-coated glass plates under solar exposure显示文摘 | Jorge M V Claudio F R Jorge R O | 2009 | Industrial & Engineering Chemistry Research2009，48，： | 1 |
| 7 | Inhibition of Growth of Experimental Human Endometrial Cancer by an Antagonist of Growth Hormone-Releasing Hormone显示文摘 | Engel Jorg B Keller Gunhild Schally Andrew V | 2005 | Joumal of Clinical Endocrinology&Metabolism2005，90，6： | 1 |
| 8 | Antioxidant action of rosemary extractin soybean oil submitted to thermoxidation显示文摘 | RAMALHO V C JORGE N | 2008 | RASAS Y ACEITES2008，59，2： | 1 |
| 9 | Aherosclerosis in type-2 Diabetes mellitus and insulin resistance: mechanistic links and therapeutic tar- gets 显示文摘 | Jorge P Giancarlo V Steven H | 2002 | Journal of Diabetes and its complications2002，16，6： | 1 |
| 10 | 显示文摘 | Stephanie V Isabel P S Jorge P J | 2007 | Langmuir2007，23，： | 1 |
| 11 | Detection of Cheaters in Vector Space Secret Sharing Schemes显示文摘 | Jorge L V | 1999 | Designs Codes and Cryptography1999，16，1： | 1 |
| 12 | Catalytic and photocatalytic ozonation of phenol on MnO2 supported catalysts 显示文摘 | JORGE V PATRICIO R GINA P | 2002 | Catalysis Today2002，76，： | 1 |
| 13 | Dendritic cell subset ratio in tolerant,weaning and non-tolerant liver recipients is not affected by extent of immunosuppression显示文摘 | George V Alan F Jorge R | 2005 | Am J Transplant2005，5，： | 1 |
| 14 | Trends in hydrological parameters of a southern Brazilian watershed and its relation to human induced changes 显示文摘 | JORGE M M GIAMPAOLO Q P MARIA V B | 1998 | Water Resources Management1998，12，4： | 1 |
| 15 | Biochemical and physiological mechanism mediated by allelochemicals显示文摘 | Tiffany L W Sang W P Jorge M V | 2004 | Current Opinion in Plant Biology2004，7，： | 1 |
| 16 | Combined effect of bacteriocins on the survival of various Listeria species in broth and meat system显示文摘 | GRACIELA V JORGE P FERNANDO S | 2000 | Curt Microbiol2000，41，6： | 1 |
| 17 | Genetic mapping of resistance to bacterial blight disease in cassava(Manihot esculenta Crantz)显示文摘 | Jorge V Fregene M A Duque M C | 2000 | Theor Appl Genet2000，，101： | 1 |
| 18 | Mn( 111 )tetrakis ( 4-Benzoic acid ) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury显示文摘 | Lokanadla V Diao Y Jorge EH | 2012 | CNS &Neurological Disorders- Drug Targets2012，11，5： | 1 |
| 19 | The effect of different training programs on antioxidant status,oxidative stress,and metabolic control in type 2diabetes显示文摘 | De Oliveira V N Bessa A Jorge M L | 2012 | Appl Physiol Nutr Metab2012，37，2： | 1 |
| 20 | Vision-based active safety system for automatic stopping显示文摘 | VICENTE M DAVID F L JORGE V | 2012 | Expert systems with applications2012，39，11： | 1 |
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