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| 1 | Genome-wide MicroRNA Expression Profiles in COPD: Early Predictors for Cancer Development显示文摘Chronic obstructive pulmonary disease(COPD) significantly increases the risk of developing cancer. Biomarker studies frequently follow a case-control set-up in which patients diagnosed with a disease are compared to controls. Longitudinal cohort studies such as the COPD-centered German COPD and SYstemic consequences-COmorbidities NETwork(COSYCONET) study provide the patient and biomaterial base for discovering predictive molecular markers. We asked whether microRNA(miRNA) profiles in blood collected from COPD patients prior to a tumor diagnosis could support an early diagnosis of tumor development independent of the tumor type. From 2741 participants of COSYCONET diagnosed with COPD, we selected 534 individuals including 33 patients who developed cancer during the follow-up period of 54 months and 501 patients who did not develop cancer, but had similar age, gender and smoking history. Genome-wide miRNA profiles were generated and evaluated using machine learning techniques. For patients developing cancer we identified nine miRNAs with significantly decreased abundance(two-tailed unpaired t-test adjusted for multiple testing P < 0.05), including members of the miR-320 family. The identified mi RNAs regulate different cancer-related pathways including the MAPK pathway(P = 2.3 x 10^(-5)). We also observed the impact of confounding factors on the generated miRNA profiles, underlining the value of our matched analysis. For selected miRNAs, qRT-PCR analysis was applied to validate the results. In conclusion, we identified several miRNAs in blood of COPD patients, which could serve as candidates for biomarkers to help identify COPD patients at risk of developing cancer. | Andreas Keller Tobias Fehlmann Nicole Ludwig Mustafa Kahraman Thomas Laufer Christina Backes Claus Vogelmeier Caroline Diener Frank Biertz Christian Herr Rudolf A. Jorres Hans-Peter Lenhof Eckart Meese Robert Bals | 2018 | Genomics, Proteomics & Bioinformatics2018，16，3： | 9 |
| 2 | Plant proteomics update(2007-2008):second-generation proteomic techniques,an appropriate experimental design,and data analysis to fulfill MIAPE standards,increase plant proteome coverage and expand biological knowledge显示文摘 | Jorrín-Novo JV Maldonado AM Echevarría-Zome?o S | 2009 | Journal of Proteomics2009，72，3： | 1 |
| 3 | Nutritional status in patients with chronic respiratory failure receiving home mechanical ventilation:impact on survival显示文摘 | Hitzl AP Jorres RA Heinemann F | 2010 | Clin Nutr2010，29，1： | 1 |
| 4 | The prevalence of incipient tubular dysfunction off and on glomerular dysfunction is increased in patients with diabetes onset in childhood 显示文摘 | Kordonouri O Kahl A Jorres A | 2011 | J Diabetes Compliction2011，13，5： | 1 |
| 5 | Crenate broomrape control in pea by foliar application of benzothiadiazole (BTH)显示文摘 | Pérez-de-Luque A Jorrín JV Rubiales D | 2004 | Phytoparasitica2004，32，1： | 1 |
| 6 | Sleep apnea is an in- dependent correlate of erectile and sexual dysfunction显示文摘 | Budweiser S Enderlein S Jorres RA | 2009 | The jour- nal of sexual medicine2009，6，11： | 1 |
| 7 | Anti-infiammatoryeffects of low- dose oral theophylline in atopic asthma显示文摘 | Sullivan P J Bekir S Jorres Z | 1994 | Lancet1994，3，43： | 1 |
| 8 | Artificial extractor-poreal liver support therapy in patients with severe liver failure显示文摘 | Rademacher S Oppert M Jorres A | 2011 | Ex- pert Rev Gastroenterol Hepatol2011，5，5： | 1 |
| 9 | The therapeutic effect of theophyl- line in mild obstructive sleep Apnea/ Hypenea syndrome: results of repeated measurements with portable recording devices at home 显示文摘 | Hein H Behnke G Jorres RA | 2000 | Eur J Med Res2000，5，9： | 1 |
| 10 | Polymerization of (3S,6S)-3 isopropyl 6-methyl-2,5-morpholinedione with tin-octoate and tin-acetylacetonate 显示文摘 | Volker Jorres Helmut Keul Hartwig Hocker | 1998 | Macromolecular Chemistry and Physics1998，199，5： | 1 |
| 11 | Impact of noninvasive home ventilation on long-term survival in chronic hypercapnic COPD: a prospective observational study 显示文摘 | Budweiser S Hitzl AP Jorres RA | 2007 | Int J Clin Pract2007，61，9： | 1 |
| 12 | Application of proteomics to the assessment of the response to ionising radiation in Arabidopsis thaliana显示文摘 | Gicquel M Esnault M A Jorrín-Novo J V | | 0，，08： | 1 |
| 13 | Changes in sputum composition during sputum induction in healthy and asthmatic subjects 显示文摘 | HOLZ O JORRES R A KOSCHYK S | 1998 | Clin Exp Allergy1998，28，3： | 1 |
| 14 | Sleep apnea is an independent correlate of erectile and sexual dysfunction显示文摘 | Budweiser S Enderlein S Jorres RA | 2009 | J Sex Med2009，6，11： | 1 |
| 15 | Interleukin-17: a mediator of inflammatory responses显示文摘 | Witowski J Ksiazek K Jorres A | 2004 | Cell Mol Life Sci2004，61，5： | 1 |
| 16 | Therapeutic approaches in metastatic renal cell carcinoma:local immunotherapy显示文摘 | Huland E Heinzer H Jorres RA | 2004 | Urologe A2004，43，： | 1 |
| 17 | 显示文摘 | Holz O Jorres RA Magnussen H | 2000 | Respir Med2000，94，： | 1 |
| 18 | Studying participation networks in collaboration using mixed methods显示文摘 | Alejandra Martínez Yannis Dimitriadis Eduardo Gómez-Sánchez Bartolomé Rubia-Avi Iván Jorrín-Abellán Jose A. Marcos | 2006 | International Journal of Computer - Supported Collaborative Learning2006，，3： | 1 |
| 19 | Long-term changes of sexual function in men with obstructive sleep apnea after initiation of continuous positive airway pressure显示文摘 | Budweiser S Luigart R Jorres RA | 2013 | J Sex Med2013，10，： | 1 |
| 20 | Impact of noninvasive home ventilation on long term survival in chronic hypecapnic COPD:a prospective observational study显示文摘 | Budweiser S Hitzl AP Jorres RA | 2007 | Int J Clin Pract2007，61，： | 1 |
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