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| 1 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 2 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
| 3 | Drug-Induced Liver Injury Network (DILIN) Prospective Study: Rationale, Design and Conduct显示文摘 | Fontana Robert J Watkins Paul B Bonkovsky Herbert L Chalasani Naga Davern Timothy Serrano Jose Rochon James | 2009 | Drug Safety2009，，1： | 2 |
| 4 | Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States显示文摘 | Naga Chalasani Robert J. Fontana Herbert L. Bonkovsky Paul B. Watkins Timothy Davern Jose Serrano Hongqiu Yang James Rochon | 2008 | Gastroenterology2008，，6： | 2 |
| 5 | Causes, Clinical Features, and Outcomes From a Prospective Study of Drug-Induced Liver Injury in the United States显示文摘 | Naga Chalasani Robert J. Fontana Herbert L. Bonkovsky Paul B. Watkins Timothy Davern Jose Serrano Hongqiu Yang James Rochon | 2008 | Gastroenterology2008，，6： | 2 |
| 6 | Chiral codendrimers derived from poly (propyleneimine) dendrimers (DAB)显示文摘 | Jose Luis Serrano Mercedes Marcos Rafael Martin | 2003 | Chem Mater2003，15，20： | 1 |
| 7 | Albumin-bound paclitaxel as new treatment for metastatic cholangiocarcinoma: A case report显示文摘BACKGROUND Cholangiocarcinomas are rare and very aggressive tumors.Most patients have advanced-stage or unresectable disease at presentation,and the systemic therapies have limited efficacy.Albumin-bound paclitaxel(nab-paclitaxel)is a solvent-free taxane that has been approved for the treatment of some cancers such as breast,non-small cell lung and pancreatic cancer,however it has not been applied to treat cholangiocarcinoma.We have both preclinical and clinical evidence of the efficacy of nab-paclitaxel in cholangiocarcinoma,yet no phase 3 trials have been made.CASE SUMMARY A 63-year-old man was diagnosed in December 2016 with stage III B intrahepatic cholangiocarcinoma.Surgery was performed,followed by adjuvant chemotherapy treatment with capecitabine and gemcitabine;although,the gemcitabine was suspended due to allergic reaction after two cycles.In April 2019,metastatic cholangiocarcinoma relapse was diagnosed,and a first-line treatment with FOLFOX scheme was started.Eight cycles were administered,producing an initial clinical improvement and decrease in blood tumor marker levels.Radiological and serological progression was noted in September 2019.As a second-line treatment,FOLFIRI was not recommended due to risk of worsening the patient’s tumor-related diarrhea.A combination therapy with gemcitabine was not feasible,as the patient had previously suffered from an allergic reaction to this treatment.We decided to use nab-paclitaxel as a second-line treatment,and four cycles were administered.Both clinical and serological responses were observed,and a radiological mixed response was also noted.CONCLUSION Advanced cholangiocarcinoma could be treated with nab-paclitaxel monotherapy,which should be studied in combination with other types of treatment(chemotherapy,fibroblast growth factor receptor inhibitors). | Roberto Martin Huertas Raquel Fuentes-Mateos Juan Jose Serrano Domingo Elena Corral de la Fuente Mercedes Rodríguez-Garrote | 2020 | World Journal of Clinical Oncology2020，11，10： | 1 |
| 8 | Idiosyncratic Drug-Induced Liver Injury Is Associated With Substantial Morbidity and Mortality Within 6 Months From Onset显示文摘 | Robert J. Fontana Paul H. Hayashi Jiezhun Gu K. Rajender Reddy Huiman Barnhart Paul B. Watkins Jose Serrano William M. Lee Naga Chalasani Andrew Stolz Timothy Davern Jayant A. Talwakar | 2014 | Gastroenterology2014，，： | 1 |
| 9 | Total factor productivity measurement and human capital in OECD countries 显示文摘 | Joaquin Maudos Jose Manuel Pastor Lorenzo Serrano | 1999 | Economics Letters1999，63，： | 1 |
| 10 | Human capital in OECD countries: technical change, efficiency and productivity显示文摘 | Joaquin Maudos Jose Manuel Pastor Lorenzo Serrano | 2003 | International Review of Applied Economics2003，，4： | 1 |
| 11 | Productivity, efficiency and technical change in the European railways: A non-parametric approach 显示文摘 | Pedro Cantos Jose M Pastor Lorenzo Serrano | 1999 | Transportation1999，26，4： | 1 |
| 12 | Natural attenuation of diesel aliphatic hydrocarbons in contaminated agricultural soil显示文摘 | Antonio Serrano Mercedes Gallego Jose Luis González Manuel Tejada | 2007 | Environmental Pollution2007，，3： | 1 |
| 13 | Combined effect of the methanol utilization (Mut) phenotype and gene dosage on reecombinant protein production in Pichia pastoris fed-batch cultures显示文摘 | Oriol Cos Alicia Serrano Jose Luis Montesinos | 2005 | Journal of Biotechnology2005，，116： | 1 |
| 14 | Ionic azo-codendrimers: Influence of the acids contents in the liquid crystalline properties and the photoinduced optical anisotropy 显示文摘 | Silvia Hernandez-Ainsa Rafael Alcala Joaquln Barbera Mercedes Marcus Carlos Sanchez Jose Luis Serrano | 2011 | European Polymer Journal2011，47，： | 1 |
| 15 | Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an “in vitro” replicative system显示文摘 | Marta R. Romero Thomas Efferth Maria A. Serrano Beatriz Casta?o Rocio I.R. Macias Oscar Briz Jose J.G. Marin | 2005 | Antiviral Research2005，，2： | 1 |
| 16 | Serial Changes in Plasma Levels of Cytokines in Patients with Coronary Artery Disease显示文摘 | Roberto H Heinisch Carlos R Zanetti 1 Fabiano Comin Juliano L Femandes Jose A Ramires and Carlos V Serrano Jr | 2005 | Vasc Health Risk Manag2005，1，3： | 1 |
| 17 | Liver Injury From Tumor Necrosis Factor-α Antagonists: Analysis of Thirty-four Cases显示文摘 | Marwan Ghabril Herbert L. Bonkovsky Clarissa Kum Tim Davern Paul H. Hayashi David E. Kleiner Jose Serrano Jim Rochon Robert J. Fontana Maurizio Bonacini | 2013 | Clinical Gastroenterology and Hepatology2013，，5： | 1 |
| 18 | Interventional radiology treatment for pulmonary embolism显示文摘Venous thromboembolism(VTE) is an illness that has a potentially life-threatening condition that affects a large percentage of the global population. VTE with pulmonary embolism(PE) is the third leading cause of death after myocardial infarction and stroke. In the first three months after an acute PE, there is an estimated 15% mortality among submassive PE, and 68% mortality in massive PE. Current guidelines suggest fibrinolytic therapy regarding the clinical severity, however some studies suggest a more aggressive treatment approach. This review will summarize the available endovascular treatments and the different techniques with its indications and outcomes. | Miguel A De Gregorio Jose A Guirola Celia Lahuerta Carolina Serrano Ana L Figueredo William T Kuo | 2017 | World Journal of Radiology2017，9，7： | 1 |
| 19 | Liver Injury From Tumor Necrosis Factor-α Antagonists: Analysis of Thirty-four Cases显示文摘 | Marwan Ghabril Herbert L. Bonkovsky Clarissa Kum Tim Davern Paul H. Hayashi David E. Kleiner Jose Serrano Jim Rochon Robert J. Fontana Maurizio Bonacini | 2013 | Clinical Gastroenterology and Hepatology2013，，5： | 1 |
| 20 | Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury显示文摘 | Timothy J. Davern Naga Chalasani Robert J. Fontana Paul H. Hayashi Petr Protiva David E. Kleiner Ronald E. Engle Hanh Nguyen Suzanne U. Emerson Robert H. Purcell Hans L. Tillmann Jiezhun Gu Jose Serrano Jay H. Hoofnagle | 2011 | Gastroenterology2011，，5： | 1 |
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