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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | Outcomes after arthroscopic repair of rotator cuff tears in the setting of mild to moderate glenohumeral osteoarthritis显示文摘BACKGROUND Rotator cuff pathology is a very common source of shoulder pain.Similarly,osteoarthritis of the glenohumeral joint can cause shoulder pain and produce similar symptoms.Surgical management can be indicated for both pathologies,however,outcomes data is limited when examining rotator cuff repair(RCR) in the setting of glenohumeral arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of GHOA.AIM To evaluate if a relationship exists between outcomes of RCR in the setting of GHOA.METHODS This was a retrospective analysis of patients who underwent arthroscopic rotator cuff repair with concurrent glenohumeral osteoarthritis between 2010-2017.Patients were stratified based on rotator cuff tear size and glenohumeral osteoarthritis severity.Cohorts were paired 1:1 with patients without glenohumeral osteoarthritis.Patients included had a minimum two year follow-up.Rate of conversion to total shoulder arthroplasty,complication rates following initial surgery,and patient-reported outcome measures were collected.RESULTS A total of 142 patients were included.The number of patients that required total shoulder arthroplasty within two years after index surgery was low.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without GHOA.Following rotator cuff repair,both groups showed favorable patientreported outcomes.CONCLUSION Patients with glenohumeral osteoarthritis who underwent arthroscopic rotator cuff repair showed comparable outcomes to patients without glenohumeral osteoarthritis. | Ian S Hong Allison J Rao Tyler L CarlLee Joshua D Meade Daniel J Hurwit Gregory Scarola David P Trofa Shadley C Schiffern Nady Hamid Patrick M Connor James E Fleischli Bryan Michael Saltzman | 2022 | World Journal of Orthopedics2022，13，7： | 2 |
| 3 | Acute ischaemic stroke interventions: large vessel occlusion and beyond显示文摘Care for acute ischaemic stroke is one of the most rapidly evolving fields due to the robust outcomes achieved by mechanical thrombectomy.Large vessel occlusion(LVO)accounts for up to 38%of acute ischaemic stroke and comes with devastating outcomes for patients,families and society in the pre-intervention era.A paradigm shift and a breakthrough brought mechanical thrombectomy back into the spotlight for acute ischaemic stroke;this was because five randomised controlled trials from several countries concluded that mechanical thrombectomy for acute stroke offered overwhelming benefits.This review article will present a comprehensive overview of LVO management,techniques and devices used,and the future of stroke therapy.In addition,we review our institution experience of mechanical thrombectomy for posterior and distal circulation occlusion. | Ahmad Sweid Batoul Hammoud Sunidhi Ramesh Daniella Wong Tyler D Alexander Joshua Harrison Weinberg Maureen Deprince Jaime Dougherty Dimitri Jean-Mickael Maamari Stavropoula Tjoumakaris Hekmat Zarzour Michael R Gooch Nabeel Herial Victor Romo David M Hasan Robert H Rosenwasser Pascal Jabbour | 2020 | Stroke & Vascular Neurology2020，5，1： | 2 |
| 4 | Contiuous and bilevel positive airway pressure in the treatment of acute cardiogenic pulmonary edema 显示文摘 | Joshua M Kosowsky M D Alan B | 2000 | Am J Emerg Med2000，18，1： | 1 |
| 5 | The chemistry and biotransformation of tea constitu- ents 显示文摘 | Sang S M Joshua D L Ho C T | 2011 | Pharmacological Research2011，64，： | 1 |
| 6 | The basic science of con- tinuous passive motion in promoting knee health : a systematic re- view of studies in a rabbit model 显示文摘 | Derrick M Knapik BA Joshua D | 2013 | Arthroscopy2013，29，10： | 1 |
| 7 | Rationale for the use of optical mice chips for economic and accurate vehicle tracking 显示文摘 | JOSHUA D J DALE W C JON M A | 2007 | Automation Science Engineering2007，，9： | 1 |
| 8 | Multichannel polarization stabilization for coherently combined fiber laser arrays显示文摘 | Gregory D G Stuart J M Joshua E R | 2012 | Opt Lett2012，37，20： | 1 |
| 9 | A wiener filter approach to microphone leakage reduction in close-microphone applications 显示文摘 | ELIAS K K JOSHUA D R JOHN M | 2012 | IEEE Transactions on Audio Speech and Language Processing2012，20，3： | 1 |
| 10 | Use of Traceback Methods To Confirm the Source of a Multistate Escherichia coli O157:H7 Outbreak Due to In-Shell Hazelnuts显示文摘 | Miller Benjamin D Rigdon Carrie E Ball Jill Rounds Joshua M Klos Rachel F Brennan Brenda M Arends Katherine D Kennelly Patrick Hedberg Craig Smith Kirk E | 2012 | EN2012，，2： | 1 |
| 11 | Elevated rates of organic carbon, nitrogen, and phosphorus accumulation in a highly impacted mangrove wetland显示文摘 | Sanders Christian J Eyre Bradley D Santos Isaac R Machado Wilson Luiz-Silva Wanilson Smoak Joseph M Breithaupt Joshua L Ketterer Michael E Sanders Luciana Marotta Humberto Silva-Filho Emmanoel | 2014 | Geophysical Research Letters2014，，7： | 1 |
| 12 | Shallow landsliding, root reinforcement, and the spatial distribution of trees in the Oregon Coast Range 显示文摘 | Roering Joshua J Schmidt Kevin M Stock Jonathan D | 2003 | Canadian Geotechnical Journal2003，40，2： | 1 |
| 13 | An fMRI investi-gation of emotional engagement in moral judg-ment显示文摘 | Joshua D Greene R Brian Sommerville LeighE Nystrom John M Darley | 2001 | Science2001，，293： | 1 |
| 14 | Price repression in the slovak agricultural market显示文摘 | JOSHUA M D ELEONORA M | 2004 | Land Use Policy2004，21，1： | 1 |
| 15 | Shallow landsliding, root reinforcement, and the spatial distribution of trees in the Oregon Coast Range 显示文摘 | Roering Joshua J Schmidt Kevin M Stock Jonathan D | 2003 | Canadian Geotechnical Journal2003，40，2： | 1 |
| 16 | Novel EOD robot design with a Dexterous Gripper and intuitive tele- operation显示文摘 | CAREY Matthew W KURZ Eric M MAqTE Joshua D | 2011 | Worcester Polytechnic Institute Electronic Projects Co-lleetion2011，4，11： | 1 |
| 17 | Challenges of liver cancer:Future emerging tools in imaging and urinary biomarkers显示文摘Chronic liver disease has become a global health problem as a result of the increasing incidence of viral hepatitis, obesity and alcohol misuse. Over the past three decades, in the United Kingdom alone, deaths from chronic liver disease have increased both in men and in women. Currently, 2.5% of deaths worldwide are attributed to liver disease and projected figures suggest a doubling in hospitalisation and associated mortality by 2020. Chronic liver diseases vary for clinical manifestations and natural history, with some individuals having relatively indolent disease and others with a rapidly progressive course. About 30% of patients affected by hepatitis C has a progressive disease and develop cirrhosis over a 20 years period from the infection, usually 5-10 years after initial medical presentation. The aim of the current therapeutic strategies is preventing the progression from hepatitis to fibrosis and subsequently, cirrhosis. Hepatic steatosis is a risk factor for chronic liver disease and is affecting about the half of patients who abuse alcohol. Moreover non-alcoholic fatty liver disease is part of the metabolic syndrome, associated with obesity, hypertension, type Ⅱ diabetes mellitus and dyslipidaemia, and a subgroup of patients develops non-alcoholic steatohepatitis and fibrosis with subsequent cirrhosis. The strengths and pitfalls of liver biopsy are discussed and a variety of new techniques to assess liver damage from transient elastography to experimental techniques, such as in vitro urinary nuclear magnetic resonance spectroscopy. Some of the techniques and tests described are already suitable for more widespread clinical application, as is the case with ultrasound-based liver diagnostics, but others, such as urinary metabonomics, requires a period of critical evaluation or development to take them from the research arena to clinical practice. | Francesca M Trovato Joshua M Tognarelli Mary ME Crossey Daniela Catalano Simon D Taylor-Robinson Guglielmo M Trovato | 2015 | World Journal of Hepatology2015，7，26： | 1 |
| 18 | A comparion of tacrolimus (FK506) and cyclosporine for immunosuppression after cadaveric renal transplantation 显示文摘 | Joshua M | 1997 | Transplantation1997，63，： | 1 |
| 19 | Real-world cure rates for hepatitis C virus treatments that include simeprevir and/or sofosbuvir are comparable to clinical trial results显示文摘AIM To assess the real-world effectiveness and cost of simeprevir(SMV), and/or sofosbuvir(SOF)-based therapy for chronic hepatitis C virus(HCV) infection.METHODS The real-world performance of patients treated with SMV/SOF ± ribavirin(RBV), SOF/RBV, and SOF/RBV with pegylated-interferon(PEG) were analyzed in a consecutive series of 508 patients with chronic HCV infection treated at a single academic medical center. Patients with genotypes 1 through 4 were included. Rates of sustained virological response-the absence of a detectable serum HCV RNA 12 wk after the end of treatment [sustained virological response(SVR) 12]-were calculated on an intention-to-treat basis. Costs were calculated from the payer's perspective using Medicare/Medicaid fees and Redbook Wholesale Acquisition Costs. Patient-related factors associated with SVR12 were identified using multivariable logistic regression.RESULTS SVR 12 rates were as follows: 86%(95%CI: 80%-91%)among 178 patients on SMV/SOF ± RBV; 62%(95%CI: 55%-68%) among 234 patients on SOF/RBV; and 78%(95%CI: 68%-86%) among 96 patients on SOF/PEG/RBV. Mean costs-per-SVR 12 were $174442(standard deviation: ± $18588) for SMV/SOF ± RBV; $223003(± $77946) for SOF/RBV; and $126496(± $31052) for SOF/PEG/RBV. Among patients on SMV/SOF ± RBV, SVR12 was less likely in patients previously treated with a protease inhibitor [odds ratio(OR): 0.20, 95%CI: 0.06-0.56]. Higher bilirubin(OR: 0.47, 95%CI: 0.30-0.69) reduced the likelihood of SVR12 among patients on SOF/RBV, while FIB-4 score ≥ 3.25 reduced the likelihood of SVR 12(OR: 0.18, 95%CI: 0.05-0.59) among those on SOF/PEG/RBV. CONCLUSION SVR 12 rates for SMV and/or SOF-based regimens in a diverse real-world population are comparable to those in clinical trials. Treatment failure accounts for 27% of costs. | Kian Bichoupan Neeta Tandon James F Crismale Joshua Hartman David Del Bello Neal Patel Sweta Chekuri Alyson Harty Michel Ng Keith M Sigel Meena B Bansal Priya Grewal Charissa Y Chang Jennifer Leong Gene Y Im Lawrence U Liu Joseph A Odin Nancy Bach Scott L Friedman Thomas D Schiano Ponni V Perumalswami Douglas T Dieterich Andrea D Branch | 2017 | World Journal of Virology2017，6，4： | 1 |
| 20 | Patients with mutations in Csαhave reduced activation of adownstream target in epithelial tissues due to haploinsufficiency显示文摘 | Stephanie C H Joshua D G Christian A M | 2007 | The Journal of Clinical Endocrinology and Metabolism2007，92，10： | 1 |
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