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| 1 | The biological stress of early weaned piglets显示文摘Pigs experience biological stress such as physiological, environmental, and social challenges when weaned from the sow. The process of weaning is one of the most stressful events in the pig's life that can contribute to intestinal and immune system dysfunctions that result in reduced pig health, growth, and feed intake, particularly during the first week after weaning. Technological improvements in housing, nutrition, health, and management have been used to minimize some of the adverse effects of weaning stress, but a greater understanding of the biological impact of stress is needed to improve strategies to overcome weaning stress. The focus of this review paper is to briefly describe how the biological stress associated with weaning impacts intestinal morphology, structure, physiology, and intestinal immune responses that can impact subsequent production efficiencies such as growth, intake, morbidity, and mortality. | Joy M Campbell Joe D Crenshaw Javier Polo | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 83 |
| 2 | Sitagliptin in patients with non-alcoholic steatohepatitis: A randomized, placebo-controlled trial显示文摘AIM To evaluate the effect of sitagliptin vs placebo on histologic and non-histologic parameters of nonalcoholic steatohepatitis(NASH).METHODS Twelve patients with biopsy-proven NASH were randomized to sitagliptin(100 mg daily)(n=6)or placebo(n=6)for 24 wk.The primary outcome was improvement in liver fibrosis after 24 wk.Secondary outcomes included evaluation of changes in NAFLD activity score(NAS),individual components of NAS(hepatocyte ballooning,lobular inflammation,and steatosis),glycemic control and insulin resistance[including measurements of glycated hemoglobin(Hb A1C)and adipocytokines],lipid profile including free fatty acids,adipose distribution measured using magnetic resonance imaging(MRI),and thrombosis markers(platelet aggregation and plasminogen activator inhibitor 1 levels).We also sought to determine the correlation between changes in hepatic fat fraction(%)[as measured using the Iterative Decomposition of water and fat with Echo Asymmetry and Least-squares estimation(IDEAL)MRI technique]and changes in hepatic steatosis on liver biopsy.RESULTS Sitagliptin was not significantly better than placebo at reducing liver fibrosis score as measured on liver biopsy(mean difference between sitagliptin and placebo arms,0.40,P=0.82).There were no significant improvements evident with the use of sitagliptin vs placebo for the secondary histologic outcomes of NAS total score as well as for the individual components of NAS.Compared to baseline,those patients who received sitagliptin demonstrated improved Hb A1C(6.7%±0.4%vs 7.9%±1.0%,P=0.02),and trended towards improved adiponectin levels(4.7±3.5μg/m L vs 3.9±2.7μg/m L,P=0.06)and triglyceride levels(1.26±0.43 mmol/L vs 2.80±1.64 mmol/L,P=0.08).However,when compared with placebo,sitagliptin did not cause a statistically significant improvement in Hb A1C(mean difference,-0.7%,P=0.19)nor triglyceride levels(mean difference-1.10mmol/L,P=0.19)but did trend towards improved adiponectin levels only(mean difference,0.60μg/m L,P=0.095).No significant changes in anthropometrics,liver enzymes,other adipocytokines,lipid profile,thrombosis parameters,or adipose distribution were demonstrated.The MRI IDEAL procedure correlated well with steatosis scores obtained on liver biopsy in both groups at baseline and post-treatment,and the Spearman correlation coefficients ranged from r=0.819(baseline)to r=0.878(post-treatment),P=0.002.CONCLUSION Sitagliptin does not improve fibrosis score or NAS after 24 wk of therapy.The MRI IDEAL technique may be useful for non-invasive measurement of hepatic steatosis. | Tisha R Joy Charles A McKenzie Rommel G Tirona Kelly Summers Shannon Seney Subrata Chakrabarti Neel Malhotra Melanie D Beaton | 2017 | World Journal of Gastroenterology2017，23，1： | 18 |
| 3 | 早期断奶仔猪的生物学应激显示文摘当仔猪断奶后离开其母猪时,会遭遇到生物学应激,如生理的、环境的和社会的挑战。断奶过程是猪一生中最具应激性的事件,会造成肠道和免疫系统的机能障碍,结果导致猪健康状况、生长性能和采食量的降低,特别是断奶后首周内。饲养系统、营养、健康和管理技术的改进已被用来将断奶应激的一些不利影响降至最小程度,但是更好地了解应激的生物学作用,为改进能够克服断奶应激的策略所需要的。本综述的重点,是简要地描述与断奶有关的生物学应激是如何通过影响肠道形态、结构、生理和肠道免疫反应,进而可能会影响生产效率,如生长、采食量、发病率和死亡率。 | 陈建康 Joy M Campbell Joe D Crenshaw Javier Polo | 2014 | 国外畜牧学(猪与禽)2014，0，S1： | 8 |
| 4 | New con- straints on methane fluxes and rates of anaerobic meth- ane oxidation in a Gulf of Mexico brine pool via in situ mass spectrometry 显示文摘 | Wankel S D Joye S B Samarkin V A | 2010 | Deep-Sea Research Part Ii- Topical Studies in Oceanography2010，57，2123： | 1 |
| 5 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011，1，1： | 1 |
| 6 | An orally administered mul- titarget tyrosine kinase inhibitor, SU11248, is a novel potent inhibi- tor of thyroid oneogenie RET/papillary thyroid cancer kinases 显示文摘 | KIN D W JOY S JUNG H S | 2006 | J Clin Endocrinol Metab2006，91，10： | 1 |
| 7 | Characterization of competence during induction of somatic embryogenesis in Medicago sativa tissue culture显示文摘 | Finstad K Brown D C W Joy K | 1993 | Plant Cell Tissue and Organ Culture1993，34，： | 1 |
| 8 | A quantitative water air sediment interaction (QWASI) fugacity model for describing the fate of chemicals in rivers显示文摘 | Mackay D Paterson S Joy M | 1983 | Chemosphere1983，12，9： | 1 |
| 9 | Variation of Antifungal Activities of Chitosans on Plant Pathogens显示文摘 | PARK R D JO K J JOY Y | 2002 | Journal of Microbiology and Biotechnology2002，12，1： | 1 |
| 10 | A quantitative water air sediment interaction (QWASI) fugacity model for describing the fate of chemicals in lakes显示文摘 | Mackay D Joy M Paterson S | 1983 | Chemosphere1983，12，78： | 1 |
| 11 | Predicting depression in nurses显示文摘 | Joy S D Kayyali A | | 0，，02： | 1 |
| 12 | Glutamine synthetase of pea leaves I Purifieation, stabilization, and pH optima 显示文摘 | O'Neal D Joy K W | 1973 | Arch Bioehem Biophys1973，，159： | 1 |
| 13 | Vacuum electronic high power terahertz sources显示文摘 | Booske J H Dobbs R J Joye C D | 2011 | IEEE Trans on Terahertz Science And Tech-nology2011，1，1： | 1 |
| 14 | Effect of mechanical milling on the structural magnetic and dielectric properties of coprecipitated ultrafine zinc ferrite显示文摘 | SHENOY S D JOY P A ANATHARAMAN M R | 2004 | Magn Mater2004，269，2： | 1 |
| 15 | An empirical stopping power relationship for low energy electrons显示文摘 | Joy D C Luo S | 1989 | Scanning1989，11，4： | 1 |
| 16 | Operational characteristics of a 14-W 140-GHz gyrotron for dynamic nuclear polarization显示文摘 | Joye G D Griffin R G Hornstein M K | 2006 | IEEE Trans Plasma Sci2006，34，3： | 1 |
| 17 | Diagnosis of fatty liver disease: is biopsy necessary? 显示文摘 | Joy D Thava VR Scott BB | 2003 | Eur J Gastroenterol Hepatol2003，15，： | 1 |
| 18 | Characterization of competence during induction of somatic embryogenesis in Medicago sativatissue culture显示文摘 | Finstad K Brown D C W Joy K | 1993 | Plant Cell Tissue and Organ Culture1993，34，： | 1 |
| 19 | Influence of piperine onthe pharmacokinetics of curcumin in animals and humanvolunteers 显示文摘 | Shoba G Joy D Joseph T | 1989 | Planta Med1989，64，4： | 1 |
| 20 | Stress fractures in the female athlete显示文摘 | Joy EA Campbell D | 2005 | Curt Sports Med Rep2005，4，6： | 1 |
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