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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Effects of teratogenic exposures to Zn2+, Cd2+, Ni2+, Co2+ and Cu2+ on metal- lothionein and metallothionein- mRNA contents of xenopus embryos显示文摘 | Sunderman F W Jr Plownam M C Kroftova O S | 1995 | Pharmacol Toxicol1995，76，3： | 2 |
| 3 | Factors that impact health-related quality of life in adults with celiac disease:A multicenter study显示文摘AIM: To evaluate the factors involved in the impairment of health-related quality of life (HRQOL) in patients with celiac disease.METHODS: A multicenter, cross-sectional prospective study was performed in patients with celiac disease who completed two HRQOL questionnaires: the gastrointestinal quality of life index (GIQLI) and the EuroQol-5D (EQ).RESULTS: Three hundred and forty patients (163 controlled with a gluten-free diet, and 177 newly diagnosed with a normal diet) were included. The GIQLI score was significantly better in patients on a gluten-free diet (GFD) than in non-treated patients on their usual diet, both in terms of the overall score (3.3 vs 2.7, respectively; P < 0.001), as well as on the individual questionnaire dimensions. Both the preference value of the EQ as the visual analogue scale were significantly better in treated than in non-treated patients (0.93 vs 0.72 P < 0.001 and 80 vs 70 P < 0.001, respectively). Variables significantly associated with a worse HRQOL score were female gender, failure to adhere to a GFD, and symptomatic status.CONCLUSION: In untreated celiac disease, the most important factors that influence patient perception of health are the presence of symptoms and a normal diet. HRQOL improves to levels similar to those described in the general population in celiac disease patients well controlled with a GFD. | F Casellas L Rodrigo J López Vivancos S Riestra C Pantiga JS Baudet F Junquera V Puig Diví C Abadia M Papo J Gelabert JR Malagelada | 2008 | World Journal of Gastroenterology2008，14，1： | 2 |
| 4 | Phenomenological Model of a Magnetorheological Dampers 显示文摘 | Spencer Jr B F Dyke S J | 1997 | ASCE Journal of Engineer- ing Mechanics1997，123，3： | 1 |
| 5 | Phenomenological model d a magnetorheological damper ASCE 显示文摘 | Spencer Jr B F Dyke S J Sain M K | 1997 | Journal of Engineering Mechanics1997，123，3： | 1 |
| 6 | High-Throughput Production of Pyrococcus Furiosus Proteins: Considerations for Metalloproteins 显示文摘 | Jenney Jr F E Brereton P S Izumi M | 2005 | J Synchrotron Rad2005，12，： | 1 |
| 7 | Phenomenological model for magnetorheological damper显示文摘 | Spencer Jr B F Dyke S J Sain M K | 1997 | ASCE J Eng Mech1997，123，3： | 1 |
| 8 | Avian color perception predicts behavioral responses to experimental brood parasitism in chaffinches显示文摘 | Avilés JM Vikan JR Fossoy F Antonov A Moksnes A R(o)skaft E Stokke BG | | 0，，： | 1 |
| 9 | 查看详情显示文摘 | Hof F Craig S L Nuckolls C Rebek J Jr | | 0，，： | 1 |
| 10 | Reaction of o-phthalaldehyde and thiols with primary amines: formation of 1-alkyl(and aryl) thio-2-alkylisoindoles显示文摘 | Simons JR S Johnson D F | 1978 | J Org Chem1978，43，14： | 1 |
| 11 | Isolation system for vibration control of stay cables显示文摘 | Inho H Jong S L Jr Spencer B F | 2009 | Journal of Engineering Mechanics2009，135，1： | 1 |
| 12 | Modeling and control of magnetorheological dampers forseismic response reduction显示文摘 | Dyke S J Spencer Jr B F Sain M K | 1996 | Smart Materials and Structures1996，5，5： | 1 |
| 13 | Effect of early antibiotic treatment on the formation of sperm antibodies in experimentally induced epididymytis 显示文摘 | Greskovich F Mathur S Nyberg LM Jr | 1993 | Arch Androl1993，30，30： | 1 |
| 14 | Benchmark problems in structural control part I:Active mass driver system 显示文摘 | SPENCER B F Jr DYKE S J DEOSKAR H S | 1998 | Earthquake Engineering and Structural Dynamics1998，27，11： | 1 |
| 15 | Hypoxia induces cyclooxygenase-2 via the NF-kappa Bp65 transcription factor in human vascular endothelial cells 显示文摘 | SCHMEDTJE J F Jr JI Y S LIU W L | 1997 | J Biol Chem1997，272，1： | 1 |
| 16 | Environmental Production Functions and Environmental Directional Distance Functions显示文摘 | Fre R Grosskopf S Pasurka Jr C A | 2007 | Energy2007，，7： | 1 |
| 17 | Simultaneous rapid measurement of whole blood myoglobin, creatine kinase MB, and cardiac troponin I by the triage cardiac panel for detection of myocardial infarction显示文摘 | Apple F S Christenson R H Valdes R Jr | 1999 | Clin Chem1999，45，： | 1 |
| 18 | Modeling and control of magnet-orheological dampers for seismic response reduction显示文摘 | SPENCER Jr B F SAIN M K | 1996 | Smart Material Structures1996，5，5： | 1 |
| 19 | Experimental study of MR dampers for seismic protection显示文摘 | Dyke S J Spencer Jr B F Sain M K | 1998 | Smart Materials and Structures:Special Issue on Large Civil Structures1998，7，5： | 1 |
| 20 | Cardiovascular complications of obesity in adolescents显示文摘 | Orio F Jr Palomba S Cascella T | 2007 | J Endocrinol Invest2007，30，1： | 1 |
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