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| 1 | Carbamazepine solubility enhancement in tandem with swellable polymer osmotic pump tablet: A promising approach for extended delivery of poorly water-soluble drugs显示文摘Elementary osmotic pump(EOP)is a unique extended release(ER)drug delivery system based on the principle of osmosis.It has the ability to minimize the amount of the drug,accumulation and fluctuation in drug level during chronic uses.Carbamazepine(CBZ),a poorly water-soluble antiepileptic drug,has serious side effects on overdoses and chronic uses.The aim of the present study was to design a new EOP tablet of CBZ containing a solubility enhancers and swellable polymer to reduce its side effects and enhance the patient compliance.Firstly,a combination of solubilizing carriers was selected to improve the dissolution of the slightly soluble drug.Then,designing the new EOP tablet and investigating the effect of different variables of core and coat formulations on drug release behavior by single parameter optimization and by Taguchi orthogonal design with analysis of variance(ANOVA),respectively.The results showed that CBZ solubility was successfully enhanced by a minimum amount of combined polyvinyl pyrrolidone(PVP K30)and sodium lauryl sulfate(SLS).The plasticizer amount and molecular weight(MW)together with the osmotic agent amount directly affect the release rate whereas the swellable polymer amount and viscosity together with the semi-permeable membrane(SPM)thickness inversely influence the release rate.In addition,the tendency of following zero order kinetics was mainly affected by the coat components rather than those of the core.Further,orifice size does not have any significant effect on the release behavior within the range of 0.1 mm to 0.8 mm.In this study we report the successful formulation of CBZ-EOP tablets,which were similar to the marketed product Tegretol CR 200 and able to satisfy the USP criterion limits and to deliver about 80%of CBZ at a rate of approximately zero order for up to 12 h. | Hadjira Rabti Jumah Masoud Mohammed Salmani Eltayeb Sulimen Elamin Narimane Lammari Jie Zhang Qineng Ping | 2014 | Asian Journal of Pharmaceutical Sciences2014，9，3： | 4 |
| 2 | Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives显示文摘Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoid phytochemical found in many kinds of fruits and vegetables, has been shown to exert significant biological effects, such as anti-oxidant, anti-inflammatory and most particularly anti-neoplastic properties. This review is intended to summarize the most recent advances in the anti-proliferative and chemo-preventive effects of apigenin in different cancer models. Analysis of the data from the studied cancer models has revealed that apigenin exerts its anti-proliferative effects through multiple and complex pathways. This guided us to discover some controversial results about the exact role of certain molecular pathways such as autophagy in the anticancer effects of apigenin. Further, there were cumulative positive evidences supporting the involvement of certain pathways such as apoptosis, ROS and DNA damage and repair. Apigenin possesses a high potential to be used as a chemosensitizing agent through the up-regulation of DR5 pathway. According to these preclinical findings we recommend that further robust unbiased studies should consider the possible interactions between different molecular pathways. | Jumah Masoud Mohammad SALMANI ZHANG Xiao-Ping Joe Antony JACOB CHEN Bao-An | 2017 | Chinese Journal of Natural Medicines2017，15，5： | 4 |
| 3 | 浅谈我国压片机现状与发展趋势显示文摘简要介绍了国内压片机的种类、技术要点以及其生产现状与发展趋势。 | 姜慧 吕慧侠 jumah masoud 陈箐清 周建平 | 2010 | 机电信息2010，，5： | 4 |
| 4 | Manufacturing parameters and quality characteristic of spray dried jameed 显示文摘 | Jumah R Y Tashtoush B Shaker R R | 2000 | Drying Technology2000，18，45： | 1 |
| 5 | Flow and drying characteristics of a rotating jet spouted bed 显示文摘 | Jumah R Y | 1995 | Drying Technology1995，13，8： | 1 |
| 6 | Immunosuppressive properties of mesenchymal stem cells显示文摘 | Abumaree M Al Jumah M Pace RA | 2012 | Stem Cell Reviews and Reports2012，8，2： | 1 |
| 7 | Exploitation of solar energy collected by solar stills for desalination by membrane distillation显示文摘 | Banat F Jumah R Garaibeh M | 2005 | Renewable Energy2005，32，3： | 1 |
| 8 | Identification of second harmonic optical effects from vaccine coated gold microparticles显示文摘 | Jumah N A Ameer-Beg S M White N S | 2004 | Phys Med Biol2004，49，： | 1 |
| 9 | Aerodynamics of a novel rotating jet spouted bed 显示文摘 | Jumah R Y Mujumdar A S Raghavan G S V | 1998 | Chemical Engineering Journal1998，70，9： | 1 |
| 10 | Exploitation of solar energy collected by solar stills for desalination by membrane distillation显示文摘 | Jumah R Garaibeh A | 2002 | Renewable Energy2002，25，2： | 1 |
| 11 | Constant and Intermittent Drying Characteristics of Olive Cake显示文摘 | R Jumah E A1-Kteimat A A1-Hamad | 2007 | Drying Technology2007，25，9： | 1 |
| 12 | Exploitation of solar energy collected by solar stills for dosalination by membrane distillation显示文摘 | Banat F Jumah R Garaibeh A | 2002 | Renewable Energy2002，25，2： | 1 |
| 13 | Developing crop coefficients for field-grown tomato under drip irrigation with black plastic mulch显示文摘 | Amayreh Jumah Al-Abed Nassim | 2005 | Agricultural Water Management2005，73，3： | 1 |
| 14 | Manufacturing parameters and quality characteristic of spray dried jameed 显示文摘 | Jumah R Y Tashtoush B Shaker R R Zrainy A F | 2000 | Drying Technology2000，，45： | 1 |
| 15 | The immunomodulatory and neuropro- tective effects of mesenchymal stem ceils ( MSCs ) in experimental autoimmune encephalomyelitls (EAE) : a model of multiple sclero- sis (MS) 显示文摘 | A1 Jumah MA Abumaree MH | 2012 | Int J Mol Sci2012，13，7： | 1 |
| 16 | Exploitation of solar energy collected by solar stills for desalination by membrane distillation 显示文摘 | Banat F Jumah R Garaibeh A | 2002 | Renewable Energy2002，25，2： | 1 |
| 17 | Exploitation Of solar energy collected by solar stills for desalination by membrane distillation显示文摘 | Banat F Jumah R Garaibeh M | 2002 | Renewable Energy2002，25，9： | 1 |
| 18 | The effects of dollar/sterling exchange rate volatility on futures markets for coffee and cocoa 显示文摘 | Jumah A Kunst R M | 2001 | European Review of Agricultural Economics2001，28，3： | 1 |
| 19 | Human placental mesenchymal stem cells (pMSCs) play a role as immune suppressive cells by shifting macrophage differentiation from inflammatory M1 to anti-inflammatory M2 macrophages 显示文摘 | Abumaree MH A1 Jumah MA Kalionis B | 2013 | Stem Cell Rev2013，9，5： | 1 |
| 20 | Modelling and simulation of continuous and intermittent radio frequency-assisted fluidized bed drying of grains显示文摘 | Jumah R | 2005 | Food and Bioproducts processing2005，83，3： | 1 |
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