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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | NKX6.3 protects against gastric mucosal atrophy by downregulatingβ-amyloid production显示文摘BACKGROUND Atrophic gastritis is characterized by loss of appropriate glands and reduction in gastric secretory function due to chronic inflammatory processes in gastric mucosa. Moreover, atrophic gastritis is considered as a precancerous condition of gastric cancer. However, little is known about the molecular mechanism underlying gastric mucosal atrophy and its contribution to gastric carcinogenesis.Thus, we hypothesized that transcription factor NKX6.3 might be involved in maintaining gastric epithelial homeostasis by regulating amyloid β(Aβ)production.AIM To determine whether NKX6.3 might protect against gastric mucosal atrophy by regulating Aβ production.METHODS We identified NKX6.3 depletion induced cell death by cell count and Western blot assay. Production and mechanism of Aβ oligomer were analyzed by enzymelinked immunosorbent assay, Western blot, immunoprecipitation, real-timequantitative polymerase chain reaction and immunofluorescence analysis. We further validated the correlation between expression of NKX6.3, Helicobacter pylori CagA, Aβ oligomer, apolipoprotein E(ApoE), and β-secretase 1(Bace1) in 55 gastric mucosae.RESULTS NKX6.3 depletion increased both adherent and floating cell populations in HFE-145 cells. Expression levels of cleaved caspase-3,-9, and poly ADP ribose polymerase were elevated in floating HFE-145^(shNKX6.3) cells. NKX6.3 depletion produced Aβ peptide oligomers, and increased expression of ApoE, amyloid precursor protein, Aβ, Bace1, low-density lipoprotein receptor, nicastrin, high mobility group box1, and receptor for advanced glycosylation end product proteins. In immunoprecipitation assay, γ-secretase complex was stably formed only in HFE-145^(shNKX6.3) cells. In gastric mucosae with atrophy, expression of Aβpeptide oligomer, ApoE, and Bace1 was detected and inversely correlated with NKX6.3 expression. Treatment with recombinant Aβ 1-42 produced Aβoligomeric forms and decreased cell viability in HFE-145^(shNKX6.3) cells. Additionally,NKX6.3 depletion increased expression of inflammatory cytokines and cyclooxygenase-2.CONCLUSION NKX6.3 inhibits gastric mucosal atrophy by regulating Aβ accumulation and inflammatory reaction in gastric epithelial cells. | Jung Hwan Yoon Yeon Soo Lee Olga Kim Hassan Ashktorab Duane T Smoot Suk Woo Nam Won Sang Park | 2019 | World Journal of Gastroenterology2019，25，3： | 6 |
| 3 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 4 | Safety of FFR-based treatment strategies: the Munich experience显示文摘 | Rieber J Jung P Schiele T M | 2002 | Z Kardiol2002，91，3： | 2 |
| 5 | Coherent destruction of tunneling显示文摘 | Grossmann F Dittrich T Jung P | 1991 | Physical Review Letters1991，67，： | 2 |
| 6 | A novel electrochemically active and Fe (Ⅲ)-reducing bacterium phylogenetically related to Aeromonas hydrophila, isolated from a microbial fuel cell 显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiol Lett2003，223，： | 1 |
| 7 | CD44 variant isoforms promote metastasis formation by a tumor cell-matrix cross-talk that supports adhesion and apoptosis resistance 显示文摘 | Klingbeil P Marhaba R Jung T | 2009 | Mol Cancer Res2009，7，2： | 1 |
| 8 | Si-carbon core-shell composite anode in lithium secondary batteries 显示文摘 | JUNG Y S LEE K T OH SEUN M | 2007 | Electrochimica Acta2007，52，： | 1 |
| 9 | A novel electrochemically active and Fe (Ⅲ)-reducing bacterium phylogenetieally related to Aeromonas hydrophila, isolated from a microbial fuel cell显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiology Letters2003，223，： | 1 |
| 10 | Gas-phase dehydration of glycerol over ZSM-5 catalysts显示文摘 | KIM Y T JUNG K D PARK E D | 2010 | Microporous and Mesoporous Materials2010，131，13： | 1 |
| 11 | Time-domain electric-field integral equation with central finite difference 显示文摘 | Jung B H Sarkar T K | 2001 | Microwave and Optical Technology Letters2001，31，6： | 1 |
| 12 | A Novel Electrochemically Active and Fe (Ⅲ)- reducing Bacterium Aeromonas Hydrophoila Related to Clostridium Butyricum Isolated from a Microbial Fuel Cell 显示文摘 | Pham C A Jung S J Phung N T | 2003 | FEMS Microbiol Lett2003，223，： | 1 |
| 13 | Speed control of a permanent magnet synchronous motor with a torque observer: a fuzzy approach显示文摘 | Jung J W Kim T H Choi H H | 2010 | IET Control Theory and Applications2010，4，12： | 1 |
| 14 | Force tracking impedance control of robot manipulators trader unknown environment 显示文摘 | JUNG S HSIA T C BONITZ R G | 2004 | IEEE Transactions on Control Systems Technology2004，12，3： | 1 |
| 15 | Analysis of fMRI data by blind separation into independent spatial components 显示文摘 | Mckeown M J Makelg S Brown G G Jung T P Kinderman S S Bell A J and Sejnowski T J | 1998 | Human Brain Mapping1998，6，： | 1 |
| 16 | Advanced intermediate frequency zero-cwssing detection of bandpass filtered MSK signals显示文摘 | Scholand T Jung P | 2003 | lEE Electronics Letters2003，39，： | 1 |
| 17 | CpG island methylation in premalignant stages of stages of gastric carcinoma显示文摘 | Kang G H Shim T H Jung H Y | 2001 | Cancer Res2001，61，7： | 1 |
| 18 | Ribozyme-mediated cleavage of the human survivin mRNA and inhibition of antiapoptotic function of survivin in MGF-7 cells 显示文摘 | Choi K S Lee T H Jung M H | 2003 | Cancer Gene Ther2003，10，2： | 1 |
| 19 | Synthesis of mesoporous silica fiber using spinning method显示文摘 | Jung K T Chu Y H | 2002 | J Non-Cryst Solids2002，298，13： | 1 |
| 20 | Influence of Alloying Elements on Thermal Conductivity and High Temperature Strength of Copper Based Alloys 显示文摘 | Kim K T Jung W J Choi C S | 2001 | Materials Science and Technology2001，17，4： | 1 |
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