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| 1 | Diagnosis and management of bacterial infections in decompensated cirrhosis显示文摘Bacterial infections are one of the most frequent complications in cirrhosis and result in high mortality rates.Patients with cirrhosis have altered and impaired immunity,which favours bacterial translocation.Episodes of infections are more frequent in patients with decompensated cirrhosis than those with compensated liver disease.The most common and life-threatening infection in cirrhosis is spontaneous bacterial peritonitis followed by urinary tract infections,pneumonia,endocarditis and skin and soft-tissue infections.Patients with decompensated cirrhosis have increased risk of developing sepsis,multiple organ failure and death.Risk factors associated with the development of infections are severe liver failure,variceal bleeding,low ascitic protein level and prior episodes of spontaneous bacterial peritonitis (SBP).The prognosis of these patients is closely related to a prompt and accurate diagnosis.An appropriate treatment decreases the mortality rates.Preventive strategies are the mainstay of the management of these patients.Empirical antibiotics should be started immediately following the diagnosis of SBP and the first-line antibiotic treatment is third-generation cephalosporins.However,the efficacy of currently recommended empirical antibiotic therapy is very low in nosocomial infections including SBP,compared to community-acquired episodes.This may be associated with the emergence of infections caused by Enterococcus faecium and extended-spectrum β-lactamaseproducing Enterobacteriaceae,which are resistant to the first line antimicrobial agents used for treatment.The emergence of resistant bacteria,underlines the need to restrict the use of prophylactic antibiotics to patients with the greatest risk of infections.Nosocomial infections should be treated with wide spectrum antibiotics.Further studies of early diagnosis,prevention and treatment are needed to improve the outcomes in patients with decompensated cirrhosis. | Maria Pleguezuelo Jose Manuel Benitez Juan Jurado Jose Luis Montero Manuel De la Mata | 2013 | World Journal of Hepatology2013，5，1： | 44 |
| 2 | Arabidopsis SWC4 Binds DNA and Recruits the SWR1 Complex to Modulate Histone H2A.Z Deposition at Key Regulatory Genes显示文摘由在特定的 loci 的规章的区域的 SWR1 建筑群(SWR1-C ) 的 H2A.Z histone 变体的免职调制抄写。在 Arabidopsis thaliana 的变化的描述 ? 酵母 SWR1-C 的相当或相同的事物在许多发展过程为 H2A.Z 交换揭示了一个角色。不过,植物 SWR1-C 的准确作文并且指向基因怎么被招募,尚待被证实。这里,我们显示出那 SWC4,酵母 SANT 领域蛋白质 Swc4/Eaf2 的 Arabidopsis 相当或相同的事物,是与 SWR1-C 子单元交往的 DNA 有约束力的蛋白质。当 SWC4 RNAi 击倒的线显示时,我们证明 swc4-1 大美人异种是胚胎致命的 ? 包括 flowering 时间的加速,显示 SWC4 控制 embryonic 以后处理的植物、繁殖的特点地的多种的 phenotypic 改变。Transcriptomic 分析并且 H2A.Z 的染色体宽的介绍显示 SWC4 镇压很多基因的抄写包括花的综合者英尺和关键抄写因素,主要由 modulating H2A.Z 免职。有趣地, SWC4 silencing 不在 FLC 地点也不这基因的表示影响 H2A.Z 免职,以前显示出被 SWR1-C 控制的 flowering 的一个主人管理者。重要地,我们发现 SWC4 在目标基因的染色质区域认出特定的在富有的 DNA 元素并且 SWC4 silencing 一起损害在英尺有约束力的 SWR1-C,我们的数据建议 SWC4 由帮助 SWR1-C 招募和 modulating H2A.Z 调整植物生长和开发免职。 | Angeles Gomez-Zambrano Pedro Crevillen Jose M. Franco-Zorrilla Juan A. Lopez Jordi Moreno-Romero Pawel Roszak Juan Santos-Gonzalez Silvia Jurado Jesus Vazquez Claudia Kohler Roberto Solano Manuel Pineiro Jose A. Jarillo | 2018 | Molecular Plant2018，11，6： | 11 |
| 3 | Nature:研究鉴定出蛋白Nlrp9b抵抗轮状病毒感染机制显示文摘轮状病毒(rotavirus)是婴儿和儿童罹患肠胃炎和腹泻的一种最为常见的原因,每年导致全世界大约21.5万人死亡。它是高度传染性的和潜在致命性的。这种病毒特异性地感染宿主小肠中的肠上皮细胞,并且已进化出抵抗干扰素和NF-KB信号的策略来躲避免疫系统,这就提出一个问题:其他的宿主因子是否参与肠道粘膜中的抗病毒反应。不过,针对体内(特别是通过NLR炎性体)检测和限制肠道病毒的机制,人们知之甚少。 | Shu Zhu, Zheng Wei, Noah W. Palm, Yi Yang, Hua Yu, Hua-Bing Li, Geng Wang, Xuqiu Lei, Marcel R. de Zoete, Jun Zhao, Yunjiang Zheng, Haiwei Chen, Liang Shan, Richard A. Flavell Siyuan Ding, Ningguo Feng, Harry B. Greenberg Siyuan Ding, Harry B. Greenberg Penghua Wang, Yujiao Zhao Wen Pan, Jun Lu Jun Zhao, Yuval Kluger Kellie A. Jurado, Clara Abraham, Erol Fikrig Erol Fikrig, Richard A. Flavell | 2017 | 现代生物医学进展2017，17，27： | 10 |
| 4 | Diaspore weight,dispersal,growth form and central Australian plants显示文摘 | Jurado E M Westoby Nelson D | 1991 | J Ecology1991，79，： | 2 |
| 5 | Recent Advances in One‑Dimensional Micro/Nanomotors:Fabrication,Propulsion and Application显示文摘Due to their tiny size,autonomous motion and functionalize modifications,micro/nanomotors have shown great potential for environmental remediation,biomedicine and micro/nano-engineering.One-dimensional(1D)micro/nanomotors combine the characteristics of anisotropy and large aspect ratio of 1D materials with the advantages of functionalization and autonomous motion of micro/nanomotors for revolutionary applications.In this review,we discuss current research progress on 1D micro/nanomotors,including the fabrication methods,driving mechanisms,and recent advances in environmental remediation and biomedical applications,as well as discuss current challenges and possible solutions.With continuous attention and innovation,the advancement of 1D micro/nanomotors will pave the way for the continued development of the micro/nanomotor field. | Yuhong Zheng He Zhao Yuepeng Cai Beatriz Jurado‑Sanchez Renfeng Dong | 2023 | Nano-Micro Letters2023，15，2： | 2 |
| 6 | The maximum reservoir capacity of soils for persistent organic pollutants: implications for global cycling 显示文摘 | Valle M D Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 7 | The maximum reservoir capacity of soils for persistent organic pollutants: implication for global cycling 显示文摘 | Dalla Valle M Jurado E Dachs J | 2005 | Environmental Pollution2005，134，1： | 1 |
| 8 | A simple method for obtaining kinetic equations to describe the enzymatic hydrolysis ofbiopolymers显示文摘 | Gonzalez-Tello P Camacho F Jurado E | 1996 | Biotechnol1996，67，3： | 1 |
| 9 | Systemic inflammatory response syndrome caused by chronic salicylate intoxication显示文摘 | CHALASANI N ROMAN J JURADO R L | | 0，，05： | 1 |
| 10 | Effect of IL- lbeta, PGE(2) , and TGF-betal on the expression of OPG and RANKL in normal and osteoporotie primary human osteoblasts显示文摘 | Jurado S Garcia-Giralt N Dlez-PSrez A | 2010 | J Cell Biachem2010，110，2： | 1 |
| 11 | Coastal zone management:tools for establishing a set of indicators to assess beach carrying capacity(Coata del Sol-Spain)显示文摘 | Jurado E Dantas A G Carlos Pereira da Silva | 2009 | Journal of Coastal Research2009，，56： | 1 |
| 12 | Bacillus Stearothermophilus as a Model to Evaluate Membrane Toxicity of a Lipophilic Environmental Pollutant(DDT)显示文摘 | Donato M M Jurado A S Antunes-Madeira MC | 1997 | Archives of Environment Contamination and Toxicology1997，33，2： | 1 |
| 13 | Shaping the Firm' S External Search Strategy 显示文摘 | Granero A C Jurado J V Alegre J | 2014 | Innovation Management Policy and Prac- tices2014，16，3： | 1 |
| 14 | Neural Network Control for Dynamic Voltage Restorer显示文摘 | Jurado F | 2004 | IEEE Trans on Industrial Electronics2004，51，3： | 1 |
| 15 | Pilotstudy of concurrent cisplatin, 5-fluorouracil,and external beam radiotherapy prior to radical surgery +/- intraoperative electron beam in locally advanced cervical cancer 显示文摘 | Jurado M Marinez-Monge R Garcia-Foncillas J | 1999 | Gynecol Oncol1999，74，1： | 1 |
| 16 | A binary shuffled frog leap- ing algorithm for the optimal placement and sizing of photovoltaics grid-connected systems显示文摘 | Gomez-Gonzalez M Jurado F | 2011 | International Review of Electrical Engineering2011，6，1： | 1 |
| 17 | Dynamics of bacterial microbiota during lignocellulosic waste composting: Studies upon its structure, functionality and biodiversity 显示文摘 | Lopez-Gonzalez JA Suarez-Estrella F Vargas-Garcia MC Lopez MJ Jurado MM Moreno J | 2015 | Bioresour Technol2015，175，： | 1 |
| 18 | IL-17 and IFN- / expressi on in lymphocytes from patients with active tuberculosis correlates with the severity of the disease显示文摘 | Jurado J O Pasquinelli V Alvarez I B | 2012 | J Leukoe Biol2012，91，6： | 1 |
| 19 | Dynamic models of wind farms with fixed speed wind turbines显示文摘 | Femandeza L M Jose Ramon Saenza Francisco Jurado | 2006 | Renewable Energy2006，31，： | 1 |
| 20 | Comparative evolutiona ecology of seed sizes 显示文摘 | Westoby M Jurado E Leishman M 1992 | 1992 | Trends Ecology1992，7，11： | 1 |
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