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| 1 | Hepatocellular carcinoma in the elderly:Meta-analysis and systematic literature review显示文摘AIM: To conduct a meta-analysis to investigate theclinical outcomes of surgical resection and locoregional treatments for hepatocellular carcinoma(HCC) in elderly patients defined as aged 70 years or more. METHODS: Literature documenting a comparison of clinical outcomes for elderly and non elderly patients with hepatocellular carcinoma was identified by searching Pub Med, Ovid, Cochrane Library, and Web of Science databases, for those from inception to March 2015 with no limits. Dichotomous outcomes and standard meta-analysis techniques were used. Heterogeneity was tested by the Cochrane Q statistic. Pooled estimates were measured using the fixed or random effect model.RESULTS: Twenty three studies were included with a total of 12482 patients. Of these patients, 6341 were treated with surgical resection, 3138 were treated with radiofrequency ablation(RFA), and 3003 were treated with transarterial chemoembolization(TACE). Of the patients who underwent surgical resection, the elderly had significantly more respiratory co-morbidities than the younger group, with both groups having a similar proportion of cardiovascular co-morbidities and diabetes. After 1 year, the elderly group had significantly increased survival rates after surgical resection compared to the younger group(OR = 0.762, 95%CI: 0.583-0.994, P = 0.045). However, the 3-year and 5-year survival outcomes with surgical resection between the two groups were similar(OR = 0.947, 95%CI: 0.777-1.154, P = 0.67 for the third year; and OR = 1.131, 95%CI: 0.895-1.430, P = 0.304 for the fifth year). Postoperative treatment complications were similar between the elderly and younger group. The elderly group and younger group had similar survival outcomes for the first and third year after RFA(OR = 1.5, 95%CI: 0.788-2.885, P = 0.217 and OR = 1.352, 95%CI: 0.940-1.944, P = 0.104). For the fifth year, the elderly group had significantly worse survival rates compared to the younger group after RFA(OR = 1.379, 95%CI: 1.079-1.763, P = 0.01). For patients who underwent TACE, the elderly group had significantlyincreased survival compared to the younger group for the first and third year(OR = 0.664, 95%CI: 0.548-0.805, P = 0.00 and OR = 0.795, 95%CI: 0.663-0.953, P = 0.013). At the fifth year, there were no significant differences in overall survival between the elderly group and younger group(OR = 1.256, 95%CI: 0.806-1.957, P = 0.313). CONCLUSION: The optimal management strategy for elderly patients with HCC is dependent on patient and tumor characteristics. Compared to patients less than 70, elderly patients have similar three year survival after resection and ablation and an improved three year survival after TACE. At five years, elderly patients had a lower survival after ablation but similar survival with resection and TACE as compared to younger patients. Heterogeneity of patient populations and selection bias can explain some of these findings. Overall, elderly patients have similar success, if not better, with these treatments and should be considered for all treatments after assessment of their clinical status and cancer burden. | Annie K Hung Jennifer Guy | 2015 | World Journal of Gastroenterology2015，21，42： | 7 |
| 2 | Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response显示文摘混乱毛细管扩张变异(ATM ) 调停由控制导致照耀的 foci 形成,房间周期检查点,和 apoptosis 的 DNA 损坏反应。然而,在上游的发信号怎么调整 ATM,完全没被理解。这里,我们证明在照耀刺激之上, ATM 与联系并且在 DNA 双海滨裂缝的地点在 Tyr370 (Y370 ) 是由表皮的生长因素受体(EGFR ) 的 phosphorylated。内长的 EGFR 的弄空损害调停 ATM 的 foci 形成,相应再结合,和 DNA 修理。而且,有一个 EGFR kinase 禁止者, gefitinib,块 EGFR 和 ATM 协会的预告的处理,妨碍 CHK2 激活和随后的 foci 形成,和增加放射敏感度。因此,我们揭示 EGFR 直接在 DNA 损坏反应由调整 ATM 激活的批评机制,并且我们的结果建议 ATM Y370 phosphorylation 的地位有潜力用作 biomarker 成层为独自一个的任何一个放射疗法或在有 EGFR 抑制的联合的病人。 | Hong-Jen Lee Li Lan Guang Peng Wei-Chao Chang Ming-Chuan Hsu Ying-Nai Wang Chien-Chia Cheng Leizhen Wei Satoshi Nakajima Shih-Shin Chang Hsin-Wei Liao Chung-Hsuan Chen Martin Lavin K Kian Ang Shiaw-Yih Lin Mien-Chie Hung | 2015 | Cell Research2015，25，2： | 4 |
| 3 | 机器人辅助腹腔镜根治前列腺切除术的外科学习曲线:一名外科医生500病例的经验显示文摘本文分析了机器人辅助腹腔镜根治前列腺切除术(RALP)初期250例和后期250例患者。500位连续接受RALP的临床局部前列腺癌患者分为第Ⅰ组:第1-250案(2006年12月-2010年12月)和第Ⅱ组:第251-500案(2011年1月-2012年12月)。记录两组的临床特点,比较两组的操作参数和手术期并发症。评估病理结果、肿瘤细胞残留手术组织边缘和生化复发率(BCR)。我们从每50个RALP案例中分析肿瘤细胞残留手术组织边缘fPSM)和神经血管束(NVB)保留,局部肿瘤的复发风险和病理分期的关系。第Ⅱ组比第1组有更多的晚期前列腺癌(切片检查格里森分数8—10,P=0.033:临床分期T3,P=0.叭7),并呈现显著性差异。控制台时间和失血从第Ⅰ组到第Ⅱ组大幅下降(控制台时间为165.16±53.51min vs 103.37±22.04min;失血为174.56±201.32ml vs 99.80±104.77m1)。输血在第1组减少3.2%(8/250)vs第Ⅱ组减少1.2%(3/250)以及手术期并发症比率在第1组减少9.6%(24/250)VS第Ⅱ组减少5.6%(14/250)。pT3的肿瘤细胞残留手术组织边缘N49%(第1组)降到32.6%(第Ⅱ组)。每50个案例减少肿瘤细胞残留手术组织边缘(PSM)的重要趋势,包括pT3和高度危险。神经血管束(NVB)保留会严重影响高度危险患者的肿瘤细胞残留手术组织边缘(PSM)(84.1%NVB保留群vs 43.9%NVB保留群)。3年、5年和7年无BCR的幸存者分别为79.2%、75.3%和70.2%。T3的肿瘤细胞残留手术组织边缘自初期250个案例的49%大幅下降到随后250个的32.9%。每50个案例减少PSM的重要趋势,包括pT3和高度危险。因为PSM的增加,在RALP期间不建议对高度危险的前列腺癌进行神经血管束保留。 | Yen-Chuan OU Chun-Kuang Yang Kuangh-Si Chang John Wang Siu-Wan Hung Min-Che Tung Ashutosh K Tewari Vipul R Patel | 2014 | Asian Journal of Andrology2014，16，5： | 3 |
| 4 | Reaction pathway,energy barrier, and rotational state distribution for LHH2-LiH+H显示文摘 | Chen J J Hung Y M Liu D K | 2001 | J Chern Phys2001，114，21： | 1 |
| 5 | Error-Resitient Pyramid Vector Quantization for Image Compression显示文摘 | Hung A C Tsern E K | 1998 | IEEE Transactions on Image Processing1998，7，10： | 1 |
| 6 | 显示文摘 | Wong K T Hung T S Lin Y | 2002 | Org Lett2002，4，： | 1 |
| 7 | Closure of patent foramen ovale for paradoxical emboli: intermediate-term risk of recurrent neurological events following transcatheter device placement 显示文摘 | Hung J Landzberg M J Jenkins K J | 2000 | J Am Coll Cardiol2000，35，5： | 1 |
| 8 | The Central Role of CD4+ T Ceils in the Antitumor Immune Response 显示文摘 | Hung K Hayashi R Lafond-Walker A | 1998 | J Exp Med1998，188，12： | 1 |
| 9 | Computer aided product color design with artificial intelligence显示文摘 | Tsai H C Hung C Y Hung F K | | 0，，1： | 1 |
| 10 | Automatic phase shift method for islanding detection of grid connected photovoltaie inverters显示文摘 | Hung G K Chang C C Chen C L | | 0，，01： | 1 |
| 11 | On perimeter coverage in wireless sensor networks显示文摘 | Hung K S Lui K S | 2010 | IEEE Transactions on Wireless Communications2010，9，7： | 1 |
| 12 | Compact ultrawideband rectangular aperture antenna and band-notched designs 显示文摘 | LIN Y C HUNG K J | 2006 | IEEE Transactions on Antennas and Propagation2006，54，11： | 1 |
| 13 | Precision grinding and facing of copper-beryllium alloys 显示文摘 | Hung N P Zhong Z W Lee K K | 1999 | Precision Engineering1999，23，4： | 1 |
| 14 | Dissolved and particulate organic carbon in the southern East China Sea显示文摘 | HUNG J J LIN P L LIU K K | 2000 | Continental Shelf Re search2000，20，： | 1 |
| 15 | Design of robust active queue management controllers for a class of TCP communication networks显示文摘 | Chen C K Hung Y C Liao T L | 2007 | Information Sciences2007，177，19： | 1 |
| 16 | A theory of financial intermediation and growth显示文摘 | Blackburn K Hung V | 1998 | Economica1998，65，： | 1 |
| 17 | Neuroprotective effects of ganglioside may involve inhibition of nitric oxid synthase显示文摘 | Dawson TM Hung K Dawsom VL | 1995 | Ann Neurol1995，37，1： | 1 |
| 18 | A secure workflow model显示文摘 | Patrick C K Hung Kamalakar Karlapalem | 2003 | Australasian Information Security Workshop2003，21，6： | 1 |
| 19 | Scale independence of basin hypsometry and steady state topography 显示文摘 | Cheng K Y Hung J H Chang H C | 2012 | Geomorphology2012，，171172： | 1 |
| 20 | A Systematic Review and Meta analysis Evaluating Completeness and Outcomes o{ Robotic Tbyroidectomy 显示文摘 | Brian Hung Hin Lang M S Carloa K H | 2014 | The Laryngoscope2014，125，2： | 1 |
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