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| 1 | Efficacy and safety of granulocyte, monocyte/macrophage adsorptive in pediatric ulcerative colitis显示文摘AIM: To investigate efficacy and safety for granulocyte, monocyte apheresis in a population of pediatric patients with ulcerative colitis.METHODS: The ADAPT study was a prospective, openlabel, multicenter study in pediatric patients with moderate, active ulcerative colitis with pediatric ulcerative colitis activity index(PUCAI) of 35-64. Patients received one weekly apheresis with Adacolumn granulocyte, monocyte/macrophage adsorptive(GMA) apheresis over 5 consecutive weeks, optionally followed by up to 3 additional apheresis treatments over 3 consecutive weeks. The primary endpoint was the change in mean PUCAI between baseline and week 12; the secondary endpoint was improvement in PUCAI categorized as(Significant Improvement, PUCAI decrease of ≥ 35), Moderate Improvement(PUCAI decrease of 20 < 35), Small Improvement(PUCAI decrease of 10 < 20) or No change(PUCAI decrease of < 10). RESULTS: Twenty-five patients(mean age 13.5 years; mean weight 47.7 kg) were enrolled. In the intention-to-treat set(ITT), the mean value for PUCAI improvement was 22.3 [95%CI: 12.9-31.6; n = 21]. In the per-protocol(PP) set, the mean improvement was 36.3 [95%CI: 31.4-41.1; n = 8]. Significant Improvement was recorded for 9 out of 20 patients(45%); 5 out of 20 patients(25%) had Moderate Improvement and one patient(5%) had No Change in PUCAI score at week 12. In the PP set, six out of eight patients(75%) showed Significant Improvement; and in two out of eight patients(25%) Moderate Improvement was recorded. The endoscopic activity index(EAI) decreased by 3 points on average. Seven(7) out of 21(33%) patients in ITT and 4 out of 8(50%) patients in PP have used steroids during the clinical investigation. The mean steroid dosage for these patients in the ITT set decreased from a mean 12.4 mg to 10 mg daily on average from Baseline to week 12.CONCLUSION: Adacolumn; GMA apheresis treatment was effective in pediatric patients with moderate active Ulcerative Colitis. No new safety signals were reported. The present data contribute to considering GMA apheresis as a therapeutic option in pediatric patients having failed first line therapy. | Tarja Ruuska Peter Küster Lena Grahnquist Fredrik Lindgren Anne Vibeke Wewer | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 2 | Position and Velocity Estimation Via Bearings-only Observations 显示文摘 | Lindgren A G Gong K F | 1978 | IEEE Transactions on Aerospace and Electronic Systems1978，14，4： | 3 |
| 3 | Using single family in reforestation: gene diversity concerns 显示文摘 | Kang K S Lai H L Lindgren D | 2002 | Silvae Genetica2002，51，23： | 1 |
| 4 | Differential contribution of current and cumulative in dices of lead dose to neuropsychological performance by age 显示文摘 | BLEEXER M L LINDGREN K N FORD D P | 1997 | Neurology1997，48，： | 1 |
| 5 | Nitrogen sparing effect of structured triglycerides containing both medium- and long-chain fatty acids in critically ill patients; a double blind randomized controlled trial 显示文摘 | Lindgren BF Ruokonen E Magnusson-Borg K | 2001 | Clin Nutr2001，20，1： | 1 |
| 6 | Fundamental properties and performance of conventional bearings-only target motion analysis显示文摘 | Nardone S C Lindgren A Gong K | 1984 | IEEE Trans on Automatic Control1984，29，9： | 1 |
| 7 | Constrainedpolymer layers to reduce noise:reality or fiction-anexperimental inquiryintotheir effectiveness显示文摘 | Kari L Lindgren K Feng Leping | 2002 | Polymer Testing2002，，21： | 1 |
| 8 | Position and velocity estimation via bearing observation显示文摘 | Lindgren A G Gong K F | 1978 | IEEE Trans on AES1978，14，4： | 1 |
| 9 | Fertility variation and effective number in the seed production areas of Pinus radiata and Pinus pinaster 显示文摘 | BILIR N KANG K S LINDGREN D | 2003 | Silvae Genetica2003，52，2： | 1 |
| 10 | Synthesis of keto- earotenoids in the seed of Arabidopsis thaliana 显示文摘 | Stalberg K Lindgren O Ek B | 2003 | Plant J2003，36，： | 1 |
| 11 | Natriuretic peptides as predictors of non-sudden and sudden cardiac death after acute myo- cardial infarction in the beta-blocking era显示文摘 | TAPANAINEN J M LINDGREN K S MAKIKAL- LIO T H | 2004 | J Am Coll Cardiol2004，43，： | 1 |
| 12 | Biomass for heat or as transportatioo fuel? A comparison between two modelbased studies 显示文摘 | GRAHN M AZAR C LINDGREN K BERNDES G GIELEN D | 2007 | Biomass Bioenergy2007，31，1112： | 1 |
| 13 | Fundamental properties and performance of conventional bearings-only target motion analysis 显示文摘 | Nadone S C Lindgren A G Gong K F | 1984 | IEEE Transaction on AC1984，29，9： | 1 |
| 14 | A primary male autosomal linkage map of the horse genome显示文摘 | Lindgren T Sandberg K Persson H | 1998 | Genome Res1998，8，： | 1 |
| 15 | Replication of genome-wide association sig- nals in UK samples reveals risk loci for type 2 diabetes显示文摘 | Zeggini E Weeclon M N Lindgren C M Frayling T M Elliott K S Lango H | 2007 | Sci- ence2007，316，： | 1 |
| 16 | Segmental lumbar spine instability at flexion-extension radiography can be predicted by conventional radiography显示文摘 | Pitkanen M T Manninen H I Lindgren K A | 2002 | Clin Radiol2002，57，7： | 1 |
| 17 | Overcoming mcthotrexate resistance in breast cancer tumour cells by the use of a new cell,penetrating peptide 显示文摘 | Lindgren M Rosenthal-Aizman K Saar K | 2006 | Biochempharmacol2006，71，4： | 1 |
| 18 | Nonlinear Finite Element Analysis and Application to Welded Structures 显示文摘 | Runesson K Skyttebol A Lindgren L E | 2003 | Comprehensive Structural Integrity Elsevier2003，3，： | 1 |
| 19 | Regulation of transcriptional activity of the murine CD40 ligand promoter in response to signals through TCR and the costimulatory molecules CD28 and CD2显示文摘 | Lindgren H Axcrona K Leanderson T | 2001 | J Immunol2001，166，7： | 1 |
| 20 | Fundamental properties and performance of conventional bearings-only target motion analysis显示文摘 | Nadone S C Lindgren A G Gong K F | 1984 | IEEE Transaction on AC1984，19，9： | 1 |
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