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| 1 | Adenoid cystic carcinoma of breast: Recent advances显示文摘Adenoid cystic carcinoma(ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features(i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features. | Kosuke Miyai Mary R Schwartz Mukul K Divatia Rose C Anton Yong Wook Park Alberto G Ayala Jae Y Ro | 2014 | World Journal of Clinical Cases2014，2，12： | 16 |
| 2 | Hydrogen sutfide protects colon cancer cells from chemopreventative agent β-phenylethyl isothiocvanate induced apoptosis显示文摘AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of H2S are reported to range between 0.2-3.4 mmol/L in the GI tract of mice and humans. Considering such high levels we speculate that, at non-toxic concentrations, H2S may interact with chemical agents and alter the response of colonic epithelium cells to such compounds. The GI tract is a major site for the absorption of phytochemical constituents such as isothiocyanates, flavonoids, and carotenoids, with each group having a role in the prevention of human diseases such as colon cancer. The chemopreventative properties of the phytochemical agent β-phenyethyl isothiocyanate (PEITC) are well recognized. However, little is currently known about the physiological or biochemical factors present in the GI tract that may influence the biological properties of ITCs. The current study was undertaken to determine the effects of H2S on PEITC mediated apoptosis in colon cancer cells.METHODS: Induction of apoptosis by PEITC in human colon cancer HCT116 cells was assessed using classic apoptotic markers namely SubG1 population analysis,caspase-3 like activity and nuclear fragmentation and condensation coupled with the MTT (3-(4,5-dimethylthiazol2-yl)-2,5-diphenyl tetrasodium bromide) viability assay and LDH leakage.RESULTS: PEITC significantly induced apoptosis in HGT116cells as assessed by SubG1 population formation, nuclear condensation, LDH leakage and caspase-3 activity after 24 h, these data being significant from control groups (P<0.01). In contrast, co-treatment of cells with physiological concentrations of H2S (0.1-1 mmol/L) prevented PEITC mediated apoptosis as assessed using the parameters described.CONCLUSION: PEITC effectively induced cell death in the human adenocarcinoma cell line HCT116 in vitro through classic apoptotic mechanisms. However, in the presence of H2S, apoptosis was abolished. These data suggest that H2S may play a significant role in the response of colonic epithelial cells to beneficial as well as toxic agents present within the GI tract. | Peter Rose Philip K Moore Shen Han Ming Ong Choon Nam Jeffrey S Armstrong Matt Whiteman | 2005 | World Journal of Gastroenterology2005，11，26： | 13 |
| 3 | Wavefront-optimized surface retreatments of refractive error following previous laser refractive surgery: a retrospective study显示文摘Background:Retreatments are sometimes necessary to correct residual or induced refractive errors following refractive surgery.Many different combinations of primary treatment methods and retreatment techniques have been studied,however,few studies have investigated wavefront-optimized(WFO)technology for retreatment following primary refractive surgery.This study aimed to report the outcomes of WFO photorefractive keratectomy(PRK)retreatments of refractive error following previous laser refractive surgery with PRK,laser in situ keratomileusis(LASIK),or laser-assisted subepithelial keratectomy(LASEK).Methods:We reviewed records of patients who underwent WFO PRK retreatments using the Allegretto Wave Eye-Q 400 Hz Excimer Laser System(Alcon Surgical)between January 2008 and April 2011 at Walter Reed Army Medical Center and Madigan Army Medical Center.Outcomes were recorded in terms of uncorrected distance visual acuity(UDVA),manifest refraction spherical equivalent(MRSE),corrected distance visual acuity(CDVA),and complications at 1 month(M),3 M,and 6 M post-op.Results:Seventy-eight patients(120 eyes)underwent WFO PRK retreatment during the study period.Primary surgery was surface ablation in 87 eyes(78 PRK,9 LASEK)and LASIK in 33 eyes.The mean spherical equivalent before retreatment was−0.79±0.94 D(−3.00 to 1.88 D).UDVA was≥20/20 in 69 eyes(60.0%)at 1 M,54 eyes(71.1%)at 3 M,and 27 eyes(73.0%)at 6 M follow-up.MRSE was within±0.50 D of emmetropia in 78 eyes(67.8%)at 1 M,59 eyes(77.6%)at 3 M,and 25 eyes(67.6%)at 6 M follow-up.CDVA was maintained within±1 line of pre-op in 113 of 115 eyes(98.3%)at 1 M,74 of 76 eyes(97.4%)at 3 M,and 37 eyes(100%)at 6 M follow-up.Conclusion:Although follow-up was limited beyond 3 M,WFO PRK retreatments in patients with residual refractive error may be a safe and effective procedure.Further studies are necessary to determine the long-term safety and stability of outcomes. | Kevin M.Broderick Rose K Sia Denise S.Ryan Richard D.Stutzman Michael J.Mines Travis C.Frazier Mark F.Torres Kraig S.Bower | 2016 | Eye and Vision2016，3，1： | 3 |
| 4 | Antireflective transparent covers for solar devices 显示文摘 | Gombert A Glaubitt W Rose K | 2000 | Solar Energy2000，68，4： | 2 |
| 5 | A critical evaluation of sample extraction techniques for enhanced proteomic analysis of recalcitrant plant tissues 显示文摘 | SARAVANAN R S ROSE J K C | 2004 | Proteomics2004，4，： | 1 |
| 6 | Three tomato genes code for heat stress transcription factors with a region of remarkable homology to the DNA-binding domain of the yeast HSF 显示文摘 | SCHARF K D ROSE S ZOTT W | 1990 | The EMBO Journal1990，9，13： | 1 |
| 7 | Replication and amplification of novel vesicular stomatitis virus minigenomes encoding viral structural proteins 显示文摘 | Stillman E A Rose J K Whitt M A | 1995 | J Virol1995，69，： | 1 |
| 8 | Three tomato genes code for heat stress transeription factors with a region of remarkable ho- mology to the DNA-binding domain of the yeast HSF 显示文摘 | Seharf K D Rose S Zott W | 1990 | EMBO J1990，9，： | 1 |
| 9 | Ethical, regulatory and scientific challenges in paedia-tric drug development显示文摘 | ROSE K | 2008 | Pharm Med2008，22，4： | 1 |
| 10 | How genetic is school myopia显示文摘 | MORGAN I ROSE K | | 0，，01： | 1 |
| 11 | A synthetic time- reversal imaging method for structural health monito- ring显示文摘 | Wang C H Rose J T Chang F K | 2004 | Smart Materials and Structures2004，13，2： | 1 |
| 12 | Effects of human disturbances on the behavior of wintering ducks显示文摘 | PEASE M L ROSE R K BUTLER M J | 2005 | Wildlife Society Bulletin2005，33，1： | 1 |
| 13 | A Dynamic Perspective On Affect and Creativity 显示文摘 | Bledow R Rosing K Frese M | 2013 | Academy of Management Journal2013，56，2： | 1 |
| 14 | Differential expression of seven a-expansin genes during growth and ripening of pear fruit显示文摘 | Hiwasa K Rose JKC Nakano R | 2003 | Physiologia Plantarum2003，117，： | 1 |
| 15 | Radiation curing of hybrid polymer coatings 显示文摘 | Rose K Vangeneugden D Paulussen S | 2006 | Surface Coatings International part B : Coatings Transactions2006，89，1： | 1 |
| 16 | Learning - induced increase of immediate early gene messenger RNA in the chick forebrain 显示文摘 | Anokhin K V Rose S P R | 1991 | Eur J Neurosci1991，312，： | 1 |
| 17 | Gemcitabine reverses cisplatin resistance: demonstration of activity in platinum-and multidrug-resistant ovarian and peritoneal carcinoma 显示文摘 | Rose PG Mossbruger K Fusco N | 2003 | Gynecol Oncol2003，88，1： | 1 |
| 18 | Nucleotide sequences of the mRNAs encoding the vesicular stomatitis virus G and M proteins determined from cDNA clones containing the complete coding regions 显示文摘 | Rose J K C J Gallione | 1981 | J Virol1981，39，： | 1 |
| 19 | Variable block-size transform image coder显示文摘 | Dinstein I Rose K Heiman A | 1990 | IEEE Tans Comm1990，38，11： | 1 |
| 20 | Comparison of aberrometer and autorefractor measures of refractive error in children显示文摘 | Martinez AA Pandian A Sankaridurg P Rose K Huynh SC Mitchell P | 2006 | Optom Vis Sci2006，83，11： | 1 |
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