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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | Activation of theimmune system is the pivot- al event in the production of wasting dis- ease in pigs infected with Porcine ci rcovi- rus-2 (PCV-2) 显示文摘 | Krakow ka S Ellis J A M cNeilly F | 2001 | Vet Pathol2001，38，1： | 1 |
| 3 | Secretory IgA-mediated neutralization of Shigella flexneri prevents intestinal tissue destruction by down-regulating inflammatory circuits 显示文摘 | BOULLIER S TANGUY M KADAOUI KA | 2009 | J Immunol2009，183，9： | 1 |
| 4 | A global phase Ⅲ randomized controlled trial of etanercept in psoriasis:safety,efficacy,and effect of dose reduction显示文摘 | Papp KA Tyring S Lahfa M | 2005 | Br J Dermat2005，152，： | 1 |
| 5 | The activation of factor X and prothrombin by recombinant factor VⅡa in vivo is mediated by tissue factor显示文摘 | Ten Cate H Bauer KA Levi M Edgington TS Sublett RD Barzegar S | | 0，，03： | 1 |
| 6 | Evidentiary Barriers to Conviction and Two Models of Criminal Procedure:A Comparative Study显示文摘 | M Dama(s)ka | | 0，，： | 1 |
| 7 | M apping of serotypespecific,im m unodom inantepitopes in the NS-4region ofhepatitisC virus(H CV):use oftype-specific peptidesto serologically differentiate infections with H CV types1,2,and3显示文摘 | Sim m onds P Rose KA Graham S | 1993 | J Clin M icrobiol1993，31，6： | 1 |
| 8 | Graziani,Use of CeO2-b ased oxides in the three-way catalysis显示文摘 | Ka(S)par J P Fornasiero M | 1999 | Catalysis Today1999，50，： | 1 |
| 9 | Structures of Authority and Comparative Criminal Procedure显示文摘 | M Dama(s)ka | | 0，，： | 1 |
| 10 | Prognostic value of a T-cell- based interferon-gamma biomarker in children with tuberculosis contact 显示文摘 | Bakir M Millington KA Soysal A Deeks JJ Efee S Asian Y Dosanjh DP Lalvani A | 2008 | Ann Intern Med2008，149，11： | 1 |
| 11 | Ovarian carcinoma metastases to gastrointestinal tract appear to spread like colon carcinoma: implications for surgical resection显示文摘 | Hanlan KA Kargas S Schreiber M | 1995 | Gynecol Oncol1995，59，： | 1 |
| 12 | Of Hearsay and Its Analogues显示文摘 | M Dama(s)ka | | 0，，： | 1 |
| 13 | 查看详情显示文摘 | Ka(s)par J Fomasiero P Graziani M | | 0，，02： | 1 |
| 14 | BAG-l: a novel biomarker predicting long- term survival in early-stage breast cancer 显示文摘 | Turner BC Krajewski S Krajews ka M | 2001 | J Clin Oncol2001，19，4： | 1 |
| 15 | Propensity Evidencein Continental Legal System显示文摘 | M Dama(s)ka | | 0，，： | 1 |
| 16 | The Uncertain Fate of Evidentiary Transplants:Anglo-American and Continental Experiments显示文摘 | M Dama(s)ka | | 0，，： | 1 |
| 17 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 18 | 低脂和全脂乳制品对代谢综合征患者空腹血脂和血压的影响:一项随机对照试验的探索性终点显示文摘传统膳食指南推荐低脂乳制品,因为乳制品高饱和脂肪含量可加重心血管病。然而,新出现的证据表明,当摄入含复合营养的食物时,乳制品脂肪或许对心血管病危险因素无不良影响。本研究旨在比较限制乳制品膳食和富含低脂或全脂乳制品膳食对心血管病危险因素的影响。方法:在本项随机对照试验当中,72例患有代谢综合征的参与者完成4周的导入期,限制乳制品摄入(脱脂牛奶摄入量≤3份/周)。 | 袁源(摘译) 郑武洪(审校) Schmidt KA Cromer G Burhans MS Kuzma JN Hagman DK Fernando I Murray M Utzschneider KM Holte S Kraft J Kratz M | 2021 | 中华高血压杂志2021，29，10： | 1 |
| 19 | Time course of adaptation to a high-fat diet in obe sity-resistant andobesity-prone rats显示文摘 | PAGLIASSOTTI M J KNOBEL S M SHAHROKHI KA | 1994 | Am J Physiol1994，267，： | 1 |
| 20 | The neural cell adhesion molecule(NCAM)associates with and signals through p21-activated ki-nase I(Pakl)显示文摘 | Li S Leshchyns ka I Chernyshova Y Schachner M Sytnyk V | 2013 | J Neurosci2013，33，： | 1 |
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