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| 1 | Endoplasmic reticulum stress transducer old astrocyte specifically induced substance contributes to astrogliosis after spinal cord injury显示文摘Old astrocyte specifically induced substance(OASIS) is an endoplasmic reticulum(ER) stress transducer specifically expressed in astrocytes and osteoblasts. OASIS regulates the differentiation of neural precursor cells into astrocytes in the central nervous system. This study aimed to elucidate the involvement of ER stress responses stimulated via OASIS in astrogliosis following spinal cord injury. In a mouse model of spinal cord contusion injury, OASIS m RNA and protein expression were evaluated at days 7 and 14. A significant increase in OASIS m RNA on day 7 and an increase in protein on days 7 and 14 was observed in injured spinal cords. Immunostaining on day 7 revealed co-localization of OASIS and astrocytes in the periphery of the injury site. Furthermore, anti-OASIS small interfering RNA(si RNA) was injected at the injury sites on day 5 to elucidate the function of OASIS. Treatment with anti-OASIS si RNA caused a significant decrease in OASIS m RNA on day 7 and protein on days 7 and 14, and was associated with the inhibition of astrogliosis and hindlimb motor function recovery. Results of our study show that OASIS expression synchronizes with astrogliosis and is functionally associated with astrogliosis after spinal cord injury. | Atsushi Takazawa Naosuke Kamei Nobuo Adachi Mitsuo Ochi | 2018 | Neural Regeneration Research2018，13，3： | 4 |
| 2 | 多育赛多孢菌性鼻窦炎1例——致病菌的鉴定和体外抗真菌药物敏感性研究显示文摘目的报告国内首例多育赛多孢菌致鼻窦炎,并探讨致病菌的鉴定及其对抗真菌药物体外敏感性。方法取患者左侧上颌窦分泌物进行真菌培养和形态学鉴定,分离菌株β-球蛋白、rDNAITS序列分析确切鉴定,对分离菌进行7种抗真菌药体外药敏试验。结果根据菌株的形态学特点和基因序列结果鉴定为多育赛多孢菌。体外药敏试验显示该菌对7种抗真菌药物耐药。结论多育赛多孢菌所致的真菌病较少见,其确切鉴定靠形态学特征和基因分析。该菌株对多种抗真菌药物耐药。 | 帕丽达.阿布利孜 Takashi Yaguchi 罗德梅 惠艳 Katsuhiro Kamei Kazuko Nishimura | 2010 | 中国真菌学杂志2010，5，1： | 3 |
| 3 | Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer显示文摘A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube.Gastrointestinal examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric tube.Laparotomy did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant metastasis.We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography.We also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y reconstruction.The definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was uneventful.Three-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding structures.Intraoperative evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction. | Toru Nakano Tadashi Sakurai Shota Maruyama Yohei Ozawa Takashi Kamei Go Miyata Noriaki Ohuchi | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 4 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 5 | 麦门冬汤对曝露于香烟烟雾豚鼠的镇咳作用显示文摘为了阐明麦门冬汤的镇咳作用机制,以曝露于香烟烟雾的豚鼠探讨了其镇咳作用以及对支气管肺泡灌洗液中NO代谢物的影响。 | Kamei J | 2006 | 国际中医中药杂志2006，28，5： | 3 |
| 6 | An oral fluoropyrimidine agent S-1 induced interstitial lung disease:A case report显示文摘A 66-year-old Japanese man with pancreatic cancer received eleven courses of gemcitabine monotherapy.The tumor responded to gemcitabine until metastatic liver tumors progressed.Subsequently,he was treated with S-1,an oral fluoropyrimidine anticancer agent,as salvage chemotherapy.Forty-two days after initiating S-1,he presented with dyspnea and fever.Chest computed tomography showed diffuse interstitial lesions with thickening of the alveolar septa and ground glass opacity.Serum KL-6 level was elevated to 1,230 U/mL and he did not use any other drugs except insulin.Thus,the development of interstitial lung disease(ILD)was considered to be due to S-1.Arterial blood oxygen pressure was 49.6 Torr in spite of oxygen administration(5 L/min).Steroid therapy improved his symptoms and the interstitial shadows on chest radiograph.Although S-1-induced ILD has mostly been reported to be mild,clinicians should be aware that S-1 has the potential to cause fatal ILD. | Hiromichi Yamane Masahide Kinugawa Shigeki Umemura Yasuhiro Shiote Kenichiro Kudo Toshimitsu Suwaki Haruhito Kamei Nagio Takigawa Katsuyuki Kiura | 2011 | World Journal of Clinical Oncology2011，2，7： | 3 |
| 7 | Combined thoracoscopic and endoscopic surgery for a large esophageal schwannoma显示文摘A 47-year-old woman presented to our hospital with complaints of dysphagia. Esophagogastroduodenoscopy identified a submucosal tumor in the left wall of the esophagus that was diagnosed as a benign schwannoma on biopsy. Computed tomography revealed a tumor of length 60 mm in the thoracic esophagus, with its cranial edge at the level of the aortic arch. On endoscopy, a submucosal tunnel was created 40 mm proximal to the cranial edge of the tumor, and its oral end was dissected from the mucosal and muscular layers. This was followed by the resection of the entire tumor by left-sided thoracoscopy. The esophageal defect was closed in layer by continuous suture from the thoracic side. Endoscopic closure was achieved by using clips. No postoperative complications were observed. Oral diet was resumed from postoperative day 7 and the patient was discharged on postoperative day 9. This combined approach has not been described for similar tumors. Our experience demonstrated that large esophageal tumors can be safely excised with minimally invasive surgery by using a combination of thoracoscopy and endoscopy. | Yu Onodera Toru Nakano Daisuke Takeyama Shota Maruyama Yusuke Taniyama Tadashi Sakurai Takahiro Heishi Chiaki Sato Takuro Kumagai Takashi Kamei | 2017 | World Journal of Gastroenterology2017，23，46： | 2 |
| 8 | Splenectomy in living donor liver transplantation and risk factors of portal vein thrombosis显示文摘Background:Graft inflow modulation(GIM)during adult-to-adult living donor liver transplantation(LDLT)is a common strategy to avoid small-for-size syndrome,and some transplant surgeons attempt small size graft strategy with frequent GIM procedures,which are mostly performed by splenectomy,in LDLT.However,splenectomy can cause serious complications such as portal vein thrombosis and overwhelming postsplenectomy infection.Methods:Forty-eight adult-to-adult LDLT recipients were enrolled in this study and retrospectively reviewed.We applied the graft selection criteria,which routinely fulfill graft-to-recipient weight ratio≥0.8%,and consider GIM as a backup strategy for high portal venous pressure(PVP).Results:In our current strategy of LDLT,splenectomy was performed mostly due to hepatitis C and splenic arterial aneurysms,but splenectomy for GIM was intended to only one patient(2.1%).The final PVP values≤20 mmHg were achieved in all recipients,and no significant difference was observed in patient survival or postoperative clinical course based on whether splenectomy was performed or not.However,6 of 18 patients with splenectomy(33.3%)developed postsplenectomy portal vein thrombosis(PVT),while none of the 30 patients without splenectomy developed PVT after LDLT.Splenectomy was identified as a risk factor of PVT in this study(P<0.001).Our study revealed that a lower final PVP could be risk factor of postsplenectomy PVT.Conclusions:Using sufficient size grafts was one of the direct solutions to control PVP,and allowed GIM to be reserved as a backup procedure.Splenectomy should be avoided as much as possible during LDLT because splenectomy was found to be a definite risk factor of PVT.In splenectomy cases with a lower final PVP,a close follow-up is required for early detection and treatment of PVT. | Nobuhiko Kurata Yasuhiro Ogura Satoshi Ogiso Yasuharu Onishi Hideya Kamei Yasuhiro Kodera | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，4： | 2 |
| 9 | Phosphoproteome analysis of hereditary cataractous rat lens alpha-crystallin 显示文摘 | Kamei A Takamura S Nagai M | 2004 | Biol Pharm Bull2004，27，： | 1 |
| 10 | Enhanced antidepressantefficacy of sigma 1 receptor agonists in rats after chronic intracerebroventricularinfusion of beta-amyloid-(1-40) protein显示文摘 | Urane A Romieu P Roman FJ Yamada K Noda Y Kamei H | 2004 | Eur J Pharmacol2004，486，： | 1 |
| 11 | Evaluation of VEGF and VEGF-C expression in gastric cancer cells producing alphafetoprotein显示文摘 | Kamei S Kono K Amemiya H | 2003 | J Gastroenterol2003，38，6： | 1 |
| 12 | Rituximab in refractory nephrotic syndrome显示文摘 | Prytula A Iijima K Kamei K | | 0，，03： | 1 |
| 13 | Single crystals of ZSM-5/Silicalite composites显示文摘 | MIYAMOTO M KAMEI T NISHIYAMA N | 2005 | Adv Mater2005，17，： | 1 |
| 14 | Large-scale screening of TARDBP mutation in amyotrophic lateral sclerosis in Japanese 显示文摘 | lida A Kamei T Sano M | 2012 | Neurobiol Aging2012，33，4： | 1 |
| 15 | Antitumor effect o hydrolyzed anthocyanin from grape rinds and red rice显示文摘 | KOIDE T KAMEI H HASIMOTO Y | 1996 | Cancer Biotherapy and Radiopharmaceuticals1996，11，： | 1 |
| 16 | Measurement of 2-dimensional local instantaneous liquid film thickness around simulated nuclear fuel rod by uhrasonic transmission technique 显示文摘 | Kamei T Serizawa A | 1998 | Nuclear Engineering and Design1998，184，： | 1 |
| 17 | Relationship between development of diabetes and family history by gender in Japanese-Americans 显示文摘 | Nakanishi S Yamane K Kamei N | 2003 | Diabetes Res Clin Praet2003，61，2： | 1 |
| 18 | Effects of histamine on spatial me-mory deficits induced by scopolamine and evalated with radial maze performance in rats 显示文摘 | Kamei C | 2000 | Acta Pharmacol Sin2000，21，9： | 1 |
| 19 | Expression of a biologically active re-combinant follicle stimulating hormone of Japanese EelAnguilla japonica using methylotropic yeast,Pichia pasto-ris显示文摘 | HIROYASU KAMEI TSUYOSHI OHIRA YASUTOSHIYOSHIURA | 2003 | General and Comparative Endocrinology2003，134，： | 1 |
| 20 | Method for the simultaneous determination of losartan and its major metabolite,EXP- 3174,in human plasma by liquid chromatography electrospray ionization tandem mass spectrometry显示文摘 | Iwasa T Takano T Hara K Kamei T | 1999 | J Chromatogr B Biomed Sci Appl1999，734，： | 1 |
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