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| 1 | Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response显示文摘AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response(UPR) in hepatitis B(HBV) and C(HCV) infected hepatocytes.METHODS: We performed immunofluorescence confocal microscopy on 10 liver biopsies from HBV and HCV patients and tissue microarrays of HBV positive liver samples. We used specific antibodies for LC3β, cleaved caspase-3, BIP(GRP78), and XBP1 to detect autophagy, apoptosis and UPR, respectively. AntiHCV NS3 and anti-HBs antibodies were also used to confirm infection. We performed triple blind counting of events to determine the co-incidence of autophagy(LC3β punctuate), apoptosis(cleaved caspase-3), and unfolded protein response(GRP78) with HBV and HCV infection in hepatocytes. All statistical analyses were performed using SPSS software for Windows(Version 16 SPSS Inc, Chicago, IL, United States). P-values < 0.05 were considered statistically significant. Statistical analyses were performed with Mann-Whitney test to compare incidence rates for autophagy, apoptosis, and UPR in HBV- and HCV-infected cells and adjacent noninfected cells.RESULTS: Our results showed that infection of hepatocytes with either HBV and HCV induces significant increase(P < 0.001) in apoptosis(cleavage of caspase-3), autophagy(LC3β punctate), and UPR(increase in GRP78 expression) in the HCV- and HBVinfected cells, as compared to non-infected cells of the same biopsy sections. Our tissue microarray immunohistochemical expression analysis of LC3β in HBV^(Neg) and HBV^(Pos) revealed that majority of HBVinfected hepatocytes display strong positive stainingfor LC3β. Interestingly, although XBP splicing in HBVinfected cells was significantly higher(P < 0.05), our analyses show a slight increase of XBP splicing was in HCV-infected cells(P > 0.05). Furthermore, our evaluation of patients with HBV and HCV infection based on stage and grade of the liver diseases revealed no correlation between these pathological findings and induction of apoptosis, autophagy, and UPR.CONCLUSION: The results of this study indicate that HCV and HBV infection activates apoptosis, autophagy and UPR, but slightly differently by each virus. Further studies are warranted to elucidate the interconnections between these pathways in relation to pathology of HCV and HBV in the liver tissue. | Behzad Yeganeh Adel Rezaei Moghadam Javad Alizadeh Emilia Wiechec Seyed Moayed Alavian Mohammad Hashemi Bita Geramizadeh Afshin Samali Kamran Bagheri Lankarani Martin Post Payam Peymani Kevin M Coombs Saeid Ghavami | 2015 | World Journal of Gastroenterology2015，21，47： | 13 |
| 2 | Prognostic value of pre-treatment F-18-FDG PET-CT in patients with hepatocellular carcinoma undergoing radioembolization显示文摘AIM To evaluate the value of pre-treatment 18F-FDG PET/CT in patients with HCC following liver radioembolization.METHODS We identified 34 patients with HCC who underwent an FDG PET/CT scan prior to hepatic radioembolization at our institution between 2009 and 2013. Patients wereseen in clinic one month after radioembolization and then at 2-3 mo intervals. We assessed the influence of FDG tumor uptake on outcomes including local liver control(LLC), distant liver control(DLC), time to distant metastases(DM), progression free survival(PFS) and overall survival(OS).RESULTS The majority of patients were males(n = 25, 74%), and had Child Pugh Class A(n = 31, 91%), with a median age of 68 years(46-84 years). FDG-avid disease was found in 19(56%) patients with SUVmax ranging from 3 to 20. Female patients were more likely to have an FDG-avid HCC(P = 0.02). Median follow up of patients following radioembolization was 12 months(1.2-62.8 mo). FDG-avid disease was associated with a decreased 1 year LLC, DLC, DM and PFS(P < 0.05). Using multivariate analysis, FDG avidity predicted for LLC, DLC, and PFS(all P < 0.05).CONCLUSION In this retrospective study, pre-treatment HCC FDGavidity was found to be associated with worse LLC, DLC, and PFS following radioembolization. Larger studies are needed to validate our initial findings to assess the role of F-18-FDG PET/CT scans as biomarker for patients with HCC following radioembolization. | Yazan Abuodeh Arash O Naghavi Kamran A Ahmed Puja S Venkat Youngchul Kim Bela Kis Junsung Choi Benjamin Biebel Jennifer Sweeney Daniel A Anaya Richard Kim Mokenge Malafa Jessica M Frakes Sarah E Hoffe Ghassan El-Haddad | 2016 | World Journal of Gastroenterology2016，22，47： | 3 |
| 3 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
| 4 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 5 | Emulsification of heavy crude oil in water for pipeline transportation显示文摘 | Ashrafizadeh S N Kamran M | 2010 | Journal of Petroleum Science and Engineering2010，71，34： | 1 |
| 6 | Evaluation of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder显示文摘 | Kamran M Numan K Hüseyin (O) | 2005 | Diagn Inte-rvent Radiol2005，11，3： | 1 |
| 7 | Current state of the art in management of vascular complications after pediatric liver transplantation显示文摘 | Kamran Hejazi Kenari S Mirzakhani H Eslami M | 2015 | Pediatr Transplant2015，19，1： | 1 |
| 8 | Effect of low-protein diets having constant energy-to-protein ratio on performance and carcass characteristics of broiler chickens from one to thirty-five days of age 显示文摘 | Kamran Z Sarwar M Nisa M | 2008 | Poultry Science2008，87，： | 1 |
| 9 | Coordinating orders in sup- ply chains through price discounts显示文摘 | Klastorin T D Kamran M Joong S | 2002 | IIE Transactions2002，34，8： | 1 |
| 10 | Effect of low protein di- ets having constant energy to protein ratio on performance and carcass characteristics of broiler chickens from one to thirty- five days of age显示文摘 | Kamran Z Sarwar M Nisa M et a/ | 2008 | Poultry Science2008，87，3： | 1 |
| 11 | C - arm flat detector computed tomography : the technique and its applications in interventional neu- ro - radiology 显示文摘 | Kamran M Nagaraja S Byrne JV | 2010 | Neuroradiology2010，52，4： | 1 |
| 12 | Determi- nants of patientrs adherence to hypertension medications: application of health belief model among rural patients 显示文摘 | Kamran A Sadeghieh Ahari S Biria M | 2014 | Ann Med Health Sci Res2014，4，6： | 1 |
| 13 | Outcome of closed reduction and casting in displaced supracondylar fracture of humerus in children显示文摘 | Shoaib M Hussain A Kamran H | 2003 | J Ayub Med Coll Abbottabad2003，15，4： | 1 |
| 14 | Spontaneous coronary artery dissection:case series and review显示文摘 | Kamran M Guptan A Bogal M | | 0，，10： | 1 |
| 15 | Characterization of thermo-mechanical and long-term behaviors of multi-layered composite materials 显示文摘 | Anastasia M Aravind N Kamran A Khan Shannon W | 2006 | Composites Science and Technology2006，66，： | 1 |
| 16 | Effect of low - proteindiets having constant enery - to - protein ratio on performance andcarcass characteristics of broiler chickens from one to thirty - fivedays of age 显示文摘 | KAMRAN Z SARWAR M NISA M | 2008 | Poult Sci2008，87，3： | 1 |
| 17 | Pulmonary embolism of polymethyl methacrylate during percutaneous vertebroplasty and kyphoplasty 显示文摘 | Du Hwan C Edith M Kamran A | 2004 | AJR2004，183，10： | 1 |
| 18 | A compari-son of TI-201 stress-reinjection-prone SPECT and Tc-99m-sestamibi gated SPECT in the differentiation of inferior wall defects from artifacts显示文摘 | Araujo W DePuey EG Kamran M | 2000 | Nucl Med Commun2000，21，8： | 1 |
| 19 | A supply chain model with direct and retail channels显示文摘 | Aussadavut D Ming Fan Apurva Jain Kamran M | 2008 | European Journal of Operational Research2008，187，： | 1 |
| 20 | Coordinating orders in supply chains through price discounts显示文摘 | Kamran M Joong S | 2002 | ⅡE Transactions2002，34，： | 1 |
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