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| 1 | Microbial profile and antibiotic sensitivity pattern in bile cultures from endoscopic retrograde cholangiography patients显示文摘AIM:To identify the frequency of bacterial growth,the most commonly grown bacteria and their antibiotic susceptibility,and risk factors for bacterial colonization in bile collected from patients with different biliary diseases.METHODS:This prospective study was conducted between April 2010 and August 2011.Patients with various biliary disorders were included.Bile was aspirated by placing a single-use,5F,standard sphincterotome catheter into the bile duct before the injection of contrast agent during endoscopic retrograde cholangiopancreaticography (ERCP).Bile specimens were transported to the microbiology laboratory in blood culture bottles within an anaerobic transport system.Bacteria were cultured and identified according to the standard protocol used in our clinical microbiology laboratory.The susceptibilities of the organisms recovered were identified using antimicrobial disks,chosen according to the initial gram stain of the positive cultures.RESULTS:Ninety-one patients (27% male,mean age 53.7 ± 17.5 years,range:17-86 years) were included in the study.The main indication for ERCP was benign biliary disease in 79 patients and malignant disease in 12 patients.The bile culture was positive for bacterial growth in 46 out of 91 (50.5%) patients.The most frequently encountered organisms were Gram-negative bacteria including Escherichia coli (28.2%),Pseudomonas (17.3%) and Stenotrophomonas maltophilia (15.2%).There were no significant differences between patients with malignant and benign disease (58% vs 49%,P = 0.474),patients with acute cholangitis and without acute cholangitis (52.9% vs 50%,P = 0.827),patients who were empirically administered antibiotics before intervention and not administered (51.4% vs 60.7%,P = 0.384),with regard to the bacteriobilia.We observed a large covering spectrum or low resistance to meropenem,amikacin and imipenem.CONCLUSION:We did not find a significant risk factor for bacteriobilia in patients with biliary obstruction.A bile sample for microbiological analysis may become a valuable diagnostic tool as it leads to more accurate selection of antibiotics for the treatment of cholangitis. | Muhsin Kaya Remzi Bestas Fatma Bacalan Ferhat Bacaksz Esma Gülsun Arslan Mehmet Ali Kaplan | 2012 | World Journal of Gastroenterology2012，18，27： | 13 |
| 2 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 3 | Do Investment-Cash Flow Sensitivities Provide Useful Measures of Financing Constraints显示文摘 | LUIGI Z | 1997 | Quarterly Journal of Economics1997，11，： | 1 |
| 4 | Long-term down-regulation of BDNF mRNA in rat hippocampal CA1 subregion correlates with PTSD-like behavioural stress response显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2007 | Int J Neuropsychopharmacol2007，10，： | 1 |
| 5 | The immediate early gene Arc is associated with behavioral resilience to stress exposure in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2008 | Eur Neuropsychopharma2008，18，： | 1 |
| 6 | Radiology in the diagnosis and management of gastrointestinal bleeding显示文摘 | Lefkovitz Z Cappell MS Kaplan M | 2000 | Gastroenterol Clin North Am2000，29，： | 1 |
| 7 | Treatment of ex- tremely low frequency magnetic and electric field sensors via the rules of electromagnetic duality 显示文摘 | KAPLAN B Z MEMBER S | 1998 | IEEE Transactions on Magnetics1998，34，4： | 1 |
| 8 | The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | 2009 | Biol Psychiatry2009，65，： | 1 |
| 9 | Repetitive transcranial magnetic stimulation of the right dorsolateral prefrontal cortex in posttraumatic stress disorder:a double-blind,placebo-controlled study显示文摘 | Cohen H Kaplan Z Kotler M | 2004 | Am J Psychiatry2004，161，3： | 1 |
| 10 | Power spectral analysis of heart rate variability in psychiatry显示文摘 | Cohen H Matar M A Kaplan Z | 1999 | Psychother Phychosom1999，68，2： | 1 |
| 11 | Monoclonal platelet an- tigen capture assays(MAIPA) and reagents: a statement显示文摘 | Kaplan C Freedman J Foxcroft Z | 2007 | Vox Sang2007，94，4： | 1 |
| 12 | Type 2 diabetesmellitus and prognosis in early stage breast cancer women 显示文摘 | Kaplan MA Pekkolay Z* Kucukoner M | 2012 | Med Oncol2012，29，3： | 1 |
| 13 | The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder显示文摘 | Kozlovsky N Matar MA Kaplan Z | | 0，，： | 1 |
| 14 | Hippocampal mi-croinfusion of oxytocin attenuates the behavioural re-sponse to stress by means of dynamic interplay with theglucocorticoid-catecholamine responses显示文摘 | Cohen H Kaplan Z? Kozlovsky N | 2010 | J Neuroendo-crinol2010，22，8： | 1 |
| 15 | Type 2 diabetes mellitus and prognosis in early stage breast cancer women显示文摘 | Kaplan M Pekkolay Z Kucukoner M | 2012 | Med Oncol2012，29，15： | 1 |
| 16 | Anisomycin,a protein synthesis inhibitor,disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats显示文摘 | Kaplan Z Matar MA | 2006 | Biol Psychiatry2006，60，7： | 1 |
| 17 | Debridement of the pig retinal pigment epithelium in vivo 显示文摘 | Del Priore LV Hornbeck R Kaplan HJ Jones Z Valentino TL Mosinger-Ogilvie J | 1995 | Arch Ophthalmol1995，113，： | 1 |
| 18 | Serum microRNAs~ miR-30c-5p, miR-223-3p, miR-302c-3p and miR-17-5p could be used as novel non-invasive biomarkers for HCV- positive cirrhosis and hepatocellular carcinoma显示文摘 | Oksuz Z Serin MS Kaplan E | 2015 | Mol Biol Rep2015，42，3： | 1 |
| 19 | A theoretical model for the physical processes in the confined high pressure discharges of electrothermal launchers显示文摘 | Loeb A Kaplan Z | 1989 | IEEE Trans Magnetics1989，25，： | 1 |
| 20 | Determination of the molecular weight of polymethacrylate 显示文摘 | Efimova L F Kaplan S Z Flis I E | 1965 | Khimiya Tekhnologiya Topliv i Masel1965，，6： | 1 |
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