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| 1 | Intragenic antagonistic roles of protein and circRNA in tumorigenesis显示文摘circRNAs arise from back splicing events during mRNA processing, and when deregulated can play an active role in cancer. Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor. We find that circPOK regulates pro-proliferative and pro-angiogenic factors by co-activation of the ILF2/3 complex. Importantly, the expression of Pokemon protein and circRNA is aberrantly uncoupled in cancer through differential post-transcriptional regulation. Thus, we identify a novel type of genetic unit, the iRegulon, that yields biochemically distinct RNA products, circular and linear, with diverse and antithetical functions. Our findings further expand the cellular repertoire towards the control of normal biological outputs, while aberrant expression of such components may underlie disease pathogenesis including cancer. | Jlenia Guarnerio Yang Zhang Giulia Cheloni Riccardo Panella Jesse Mae Katon Mark Simpson Akinobu Matsumoto Antonella Papa Cristian Loretelli Andreas Petri Sakari Kauppinen Cassandra Garbutt Gunnlaugur Petur Nielsen Vikram Deshpande Mireia Castillo-Martin Carlos Cordon-Cardo Spentzos Dimitrios John G. Clohessy Mona Batish Pier Paolo Pandolfi | 2019 | Cell Research2019，29，8： | 15 |
| 2 | New Hybrid Copper Composite Materials Based on Carbon Nanostructures显示文摘 | Tatyana S. Koltsova Larisa I. Nasibulina Ilya V. Anoshkin Vasily V. Mishin Esko I. Kauppinen Oleg V.Tolochko Albert G. Nasibulin | 2012 | 材料科学与工程(中英文B版)2012，2，4： | 5 |
| 3 | MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors显示文摘 | Liu Xi Sempere Lorenzo F Ouyang Haoxu Memoli Vincent A Andrew Angeline S Luo Yue Demidenko Eugene Korc Murray Shi Wei Preis Meir Dragnev Konstantin H Li Hua DiRenzo James Bak Mads Freemantle Sarah J Kauppinen Sakari Dmitrovsky Ethan | 2010 | Journal of Clinical Investigation2010，，4： | 3 |
| 4 | Inflammation in Alzheimer’s disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors显示文摘 | Antero Salminen Johanna Ojala Anu Kauppinen Kai Kaarniranta Tiina Suuronen | 2009 | Progress in Neurobiology2009，，3： | 2 |
| 5 | Inflammation in Alzheimer’s disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors显示文摘 | Antero Salminen Johanna Ojala Anu Kauppinen Kai Kaarniranta Tiina Suuronen | 2009 | Progress in Neurobiology2009，，3： | 2 |
| 6 | Tailoring the Diameter of Single-Walled Carbon Nanotubes for Optical Applications显示文摘有特定的直径的围单人赛的碳 nanotubes (SWCNT ) 特别地在电子学和 photonics 为各种各样的应用被要求,自从直径是决定他们的电子、光的性质的一个必要特征。在这个工作,有某个吝啬的直径的 SWCNT 的选择生长被与碳来源(公司) 一起混合进喷雾器(漂浮的催化剂) 的 CO2 的适当数量的增加完成化学蒸汽免职反应堆。在吸收系列的山峰的显著移动表明同样扔的 SWCNT 的吝啬的直径高效地与增加 CO2 集中从 1.2 ~ 1.9 nm 被改变。当一个蚀刻的代理人和罐头有选择地由于他们的高度弄弯的碳表面蚀刻小直径试管, CO2 行动,这被相信当一个蚀刻的代理人和罐头有选择地由于他们的高度弄弯的碳表面蚀刻小直径试管。有需要的直径的没有聚合物的同样扔的 SWCNT 电影在用一种简单干燥转移的技术踩到一面高度思考的 Ag 镜子上以后被用作可饱和的吸收器。在 1.56 m 和 2 m 的亚微微秒锁模式的纤维激光操作被表明,显示出在在 SWCNT 性质的优化以后的表演的改进。 | Ying Tian Marina Y. Timmermans Samuli Kivistoe Albert G. Nasibulin Zhen Zhu Hua Jiang OlegG. Okhotnikov Esko I. Kauppinen | 2011 | Nano Research2011，4，8： | 2 |
| 7 | Pancreatic cancer in industrial branches and occupations in Finland 显示文摘 | Kauppinen T Degerth R | 1994 | Am J Ind Med1994，25，6： | 1 |
| 8 | LNA-en-hanced detection of single nucleotide polymorphisms in the apolipoprotein E显示文摘 | JACOBSEN N BENTZEN J MELDGAARD M JAKOBSEN M H FENGER M KAUPPINEN S SKOUV J | 2002 | Nucleic Acids Res2002，30，19： | 1 |
| 9 | A new line-narrowing procedure based on fourier self-deconvolution,maximum entropy, and linear prediction 显示文摘 | KAUPPINEN J K MOFFATT D J HOLLBERG M R | 1991 | Appl Spectrosc1991，45，3： | 1 |
| 10 | Extremely sen- sitive trace gas analysis with modern photoacoustic spec- troscopy显示文摘 | Koskinen V Fonsen J Kauppinen J | 2006 | Vibrational Spectroscopy2006，42，2： | 1 |
| 11 | Detection of mobile proteins by proton nuclear magnetic resonance spectroscopy in the guinea pig brain ex vivo and their partial purification显示文摘 | Kauppinen R A Kokko H Williams S R | 1992 | J Nenrochem1992，58，： | 1 |
| 12 | Pancreatic cancer and occupational exposures显示文摘 | Partanen T Degerth R | 1995 | Am J Ind Med1995，28，3： | 1 |
| 13 | Multiply twinned C60 and C70nanoparticles显示文摘 | Pauwels B Bernaerts D Amelinckx S Van Tendeloo G Joutsensaari J Kauppinen E I | 1999 | J Cryst Growth1999，200，： | 1 |
| 14 | Fourier self-deconvolution: A method for resolving intrinsically overlapped bands显示文摘 | KAUPPINEN J K MOFFATT D J MANTSCH H H | 1981 | Applied Spectroscopy1981，35，3： | 1 |
| 15 | MC inhibits poly( ADP ribose) polymeraseI at nanomolar concentrations 显示文摘 | Alano CC Kauppinen TN Vall AV | 2006 | Proc Natl Acad Sci2006，12，7： | 1 |
| 16 | LNA-modified oligonucleotides mediate specific inhibition of microRNA function 显示文摘 | Orom UA Kauppinen S Lund AH | 2006 | Gene2006，372，： | 1 |
| 17 | Adenovirus-mediated herpes simplex virus thymidine kinase gene therapy in BT4C rat glioma model 显示文摘 | Sandmair AM Turunen M Vanninen R Vainio P Kauppinen R Johansson R Vapalahti M Yla-Herttuala S | 2002 | Cancer Gene Ther2002，9，11： | 1 |
| 18 | MicroRNAs as targets for antisense-based therapeutics显示文摘 | Stenvang J Kauppinen S | 2008 | Expert Opin Biol Ther2008，8，1： | 1 |
| 19 | Noise in fourier self-deeonvolution显示文摘 | KAUPPINEN J K MOFFATT D J CAMERON D G | 1981 | Applied Optics1981，20，10： | 1 |
| 20 | A new line-narrowing procedure based on fourier selfdeconvolution,maximum entropy,and linear prediction显示文摘 | KAUPPINEN J K MOFFATT D J HOLLBERG M R | 1991 | Appl Spectrosc1991，45，3： | 1 |
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