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| 1 | Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice显示文摘AIM To clarify the roles of TWEAK and its receptor Fn14 in 5-fluorouracil(5-FU)-induced diarrhea.METHODS Diarrhea was induced in wild-type(WT), Fn14 knockout(KO), and IL-13 receptor(IL-13R)α1 KO BALB/c mice using a single injection of 5-FU. Histological analysis, cytokine analysis, and flow cytometry was performed on ileal tissues and cells. Murine colon carcinomabearing mice were co-treated with an anti-TWEAK antibody and 5-FU. Embryonic fibroblast response to cytokines was also analyzed.RESULTS5-FU induced high Fn14 expression in epithelial cells. The severity of 5-FU-induced diarrhea was lower in Fn14 KO mice compared with WT mice. Administration of anti-TWEAK antibody reduced 5-FU-induced diarrhea without affecting the antitumor effects of 5-FU in vivo. 5-FU-induced expression of IL-13, IL-17 A, TNF-α, and IFN-γ in the ileum was Fn14 dependent. The severity of 5-FU-induced diarrhea was lower in IL-13Rα1 KO mice, indicating major role for IL-13 signaling via IL-13Rα1 in pathogenesis. We found that IL-13Rα2, an IL-13 neutralizing/cell protective receptor, was strongly induced by IL-33 in vitro and in vivo. IL-13Rα2 was upregulated in the ileum of 5-FU-treated Fn14 KO mice. Thus, the deletion of Fn14 upregulated IL-13Rα2 expression, which reduced IL-13 expression and activity. CONCLUSION Disruption of the TWEAK/Fn14 pathway affects several interconnected pathways, including those associated with IL-13, IL-33, and IL-13Rα2, to attenuate 5-FUinduced intestinal side effects. | Takuhito Sezaki Yuki Hirata Teruki Hagiwara Yuki I Kawamura Tadashi Okamura Rieko Takanashi Kenta Nakano Miwa Tamura-Nakano Linda C Burkly Taeko Dohi | 2017 | World Journal of Gastroenterology2017，23，13： | 3 |
| 2 | Prodromal symptoms of out- of-hospital cardiac arrests: a report from a large-scale population-based cohort study 显示文摘 | Nishiyama C Iwami T Kawamura T | 2013 | Resuscitation2013，84，5： | 1 |
| 3 | Bisecting GlcNAc residues on laminin-332 down-regulate galectin-3 dependent keratinocyte motility 显示文摘 | Kariya Y Kawamura C Tabei T | 2010 | J Siol Chem2010，285，5： | 1 |
| 4 | The effect of osteoprotegerin on tendon-bone healing after reconstruction of the anterior cruciate ligament:ahistomorphological and radiographical study in the rabbit显示文摘 | Dynybil C Kawamura S Kim HJ | | 0，，02： | 1 |
| 5 | Social desirability, social intelligence and self-rated oral health status and behaviours显示文摘 | Dumitrescu AL Kawamura M Toma C | 2007 | Rom J Intern Med2007，45，4： | 1 |
| 6 | Molecular, seasonal and spatial distributions of organic aerosols from fourteen Chinese cities 显示文摘 | Wang G H Kawamura K Lee S C | 2006 | Environmental Science and Technology2006，40，： | 1 |
| 7 | Inhibition of ovulation,steroidogenesis and collagenolytic activity in rabbitts by sulpiride-induced hyperprolactinemia显示文摘 | Lin K C Kawamura N Okamura H | 1988 | Reprod Fert1988，83，2： | 1 |
| 8 | Inhaled hydrogen gas therapy for prevention of lung transplant-induced ischemi- a/reperfusion injury in rats显示文摘 | Kawamura T Huang C S Tochigi N | 2010 | Transplantation2010，90，12： | 1 |
| 9 | Granulomatous colitis associated with botryomycosis of Propionibacterium acnes显示文摘 | Wada R Kawamura C lnoue S | 2001 | Arch Pathol Lab Med2001，125，11： | 1 |
| 10 | Synthesis of 1-Indanones by Intramolecular Friedel-Crafts Reaction of 3- Arylpropionic Acids Catalyzed by Tb(OTf) 3 显示文摘 | Cui D M Zhang C Kawamura M | 2004 | Tetrahedron Lett2004，45，： | 1 |
| 11 | p27KIPI and GATA- 1 are potential downstream molecules in activin A-induced diferentiation and apoptosis pathways in CML cells显示文摘 | Fukuchi Y Yamatol Kawamura C | 2006 | Oncol Rep2006，16，5： | 1 |
| 12 | H∞ Tuning for task- space feedback control of robot with uncertain jacobian matrix 显示文摘 | Cheah C C Kawamura S Arimoto S | 2001 | IEEE Trans on Automatic Control2001，46，8： | 1 |
| 13 | Glycolipid composition in bladder tumor:a crucial role of GM3 ganglioside in tumor invasion显示文摘 | Kawamura S Ohyama C Watanabe R | | 0，，03： | 1 |
| 14 | B meson light-cone distribution amplitudes in the heavy-quark limit显示文摘 | KAWAMURA H KODAIRA J QIAO C F | 2001 | Phys Lett B2001，523，： | 1 |
| 15 | Errects of nitrous oxide on volume and pressure of endotracheal tube cuffs显示文摘 | Stanley TH Kawamura R Graves C | 1974 | Anesthesilology1974，215，： | 1 |
| 16 | High-speed manipulation by using parallel wire-driven robots显示文摘 | Kawamura S Kioo H Won C | 2000 | Robotica2000，18，1： | 1 |
| 17 | The effect of osteoprotegerin on tendon-bone healing after reconstruction of the anterior cruciate ligament:a histomorphological and radiographical study in the rabbit 显示文摘 | Dynybil C Kawamura S Kim HJ | 2006 | Z Orthop Ihre Grenzgeb2006，144，2： | 1 |
| 18 | Mechanical analysis of the formation of forceps and scope for single-port laparoscopic surgery显示文摘 | Kawamura H Ishii C | | 0，，4： | 1 |
| 19 | The effect of osteoprote gerin on tendon bone healing after reconstruction of the anterior cruciate ligament:a histomorphological and radiographical study in the rabbit 显示文摘 | Dynybil C Kawamura S Kim HJ | 2006 | Z Orthop Ihre Grenzgeb2006，144，2： | 1 |
| 20 | High-speed manipulation by using parallel wire-driven robots显示文摘 | Kawamura S Kino H Won C | 2000 | Robotica2000，18，1： | 1 |
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