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| 1 | Acute coronary syndromes in young patients: Presentation, treatment and outcome显示文摘 | Andreas W. Schoenenberger Dragana Radovanovic Jean-Christophe Stauffer Stephan Windecker Philip Urban Gregor Niedermaier Pierre-Frédéric Keller Felix Gutzwiller Paul Erne | 2009 | International Journal of Cardiology2009，，3： | 2 |
| 2 | The spherulitic and lamellar morphology of melt-crystallized isotactic polypropylene 显示文摘 | D R Norton A Keller | 1985 | Polymer1985，26，： | 2 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Solidstate low-loss intracavity saturable absorber for Nd:YLF lasers:An A-FPSA显示文摘 | KELLER U MILLER D A B BOYD G D | 1992 | Opt Lett1992，17，7： | 2 |
| 5 | Surgical and nonsurgical manage- ment of lumbar spinal stenosis: four - year outcomes from the Maine lumbar spine study显示文摘 | Atlas S J Keller RB Robson D | 2000 | Spine2000，25，： | 1 |
| 6 | Consumer evaluation of brand extension显示文摘 | Aaker D A Keller K L | 1990 | Journal of Marketing1990，23，6： | 1 |
| 7 | Expamins in growing tomato leavea 显示文摘 | KELLER E COSGROVE D J | 1995 | Plant J1995，8，： | 1 |
| 8 | Storm wave reactivation of a submarine landslide显示文摘 | Prior D B Suhayda J N Lu N J Bomhold B D Keller G H Wiseman W J Wright L D Yang Z S | 1989 | Nature1989，341，： | 1 |
| 9 | Surgical and nonsurgi cal management of lumber spinal stenosis:four-year outcomes from the maine lumbar spine study显示文摘 | Atlas S J Keller R B Robson D | 2000 | Spine2000，25，5： | 1 |
| 10 | Transjugular intrahepatic portosystemic shunt:present status,comparison with endoscopic therapy and shunt surgery,and future prospectives显示文摘 | J R(O)SCH M D FREDERCK S KELLER M D | 2001 | World J Surg2001，25，： | 1 |
| 11 | Peak purity control in liquid chromatography with photodiode-array detection by a fixed size moving window evolving factor analysis显示文摘 | Keller H R Massart D L | 1991 | Anal Chim Acta1991，246，4： | 1 |
| 12 | Natural products of filamen tous fungi: enzymes, genes and their regulation 显示文摘 | Hoffmeister D & Keller N P | 2007 | Nat Prod Rep2007，24，： | 1 |
| 13 | Oxylipins act as determi- nants of natural product biosynthesis and seed coloniza- tion in Aspergillus nidulans 显示文摘 | Tsitsigiannis D I Keller N P | 2006 | Molecular Microbiology2006，59，3： | 1 |
| 14 | Mesoporous TiO2-based photocatalystsfor UV and visible light gas-phase toluene degradation显示文摘 | Bosc F Edwards D Keller N | 2006 | Thin Solid Films2006，495，： | 1 |
| 15 | The carbon balance of North American Wetlands显示文摘 | Bridgham S D Megoniga J P Keller J K | 2006 | Wetlands2006，26，4： | 1 |
| 16 | Percutaneous minimal os-teosynthesis of fractures of the proximal humerus in elderly patients显示文摘 | ZinggU Brunnschweiler D Keller H | | 0，，01： | 1 |
| 17 | High temperature resorcinol- based phthalonitrile poiymer 显示文摘 | Keller T M Dominguez D D | 2005 | Polymer2005，46，： | 1 |
| 18 | Phthalonitrile-Epoxy Blends: Cure Behavior and Copolymer Properties 显示文摘 | Dominguez D D Keller T M | 2008 | Journal of Applied Poly- mer Science2008，110，： | 1 |
| 19 | Evaluating translations of health status questionnaires显示文摘 | Ware J E Keller S D Gandek B | 1995 | Int J Technol Assess in Health Care1995，11，3： | 1 |
| 20 | Human Mcm proteins at a replication origin during the G1 to S phase transition 显示文摘 | Schaarschmidt D Ladenburger EM Keller C | 2002 | Nucleic Acids Res2002，30，19： | 1 |
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