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| 1 | Evolution of transanal total mesorectal excision for rectal cancer:From top to bottom显示文摘The gold standard for curative treatment of locally advanced rectal cancer involves radical resection with a total mesorectal excision(TME). TME is the most effective treatment strategy to reduce local recurrence and improve survival outcomes regardless of the surgical platform used. However, there are associated morbidities, functional consequences, and quality of life(QoL) issues associated with TME; these risks must be considered during the modern-day multidisciplinary treatment for rectal cancer. This has led to the development of new surgical techniques to improve patient, oncologic, and QoL outcomes. In this work, we review the evolution of TME to the transanal total mesorectal excision(TaTME) through more traditional minimally invasive platforms. The review the development, safety and feasibility, proposed benefits and risks of the procedure, implementation and education models, and future direction for research and implementation of the TaTME in colorectal surgery. While satisfactory short-term results have been reported, the procedure is in its infancy, and long term outcomes and definitive results from controlled trials are pending.As evidence for safety and feasibility accumulates,structured training programs to standardize teaching,training, and safe expansion will aid the safe spread of the TaTME. | Sameh Hany Emile F Borja de Lacy Deborah Susan Keller Beatriz Martin-Perez Sadir Alrawi Antonio M Lacy Manish Chand | 2018 | World Journal of Gastrointestinal Surgery2018，10，3： | 18 |
| 2 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 3 | 直接光控晶闸管在脉冲电源上的应用显示文摘具有集成保护功能的直接光控晶闸管 (LTT)已得到了广泛应用。这种晶闸管是为高压直流输电(HVDC)而开发的。通过改进门极结构 ,光控晶闸管也可用于大功率脉冲电源上。由于采用了直接光触发 ,LTT特别适用于串联应用。 | J Przybilla R Keller U Kellner C Schneider H J Schulze F J Niedernostheide | 2002 | 电力电子技术2002，36，6： | 2 |
| 4 | Specificity of cardiac troponins Ⅰ and T in renal disease显示文摘 | Willging S Keller F Steinbach G | 1998 | Clin Chem Lab Med1998，36，： | 1 |
| 5 | Diluteacid hydrolysis of softwoods显示文摘 | Ngyuen Q A Tucker M P Keller F | 1999 | Applied Biochemistry and Biotechnology1999，77，13： | 1 |
| 6 | Antisense inhibition of the GDP-mannose pyrophosphorylase reduces the ascorbate content in transgenic plants leading to developmental changes during senescens显示文摘 | KELLER R SPRINGER F RENZ A | 1999 | Plant J1999，19，： | 1 |
| 7 | Necessary and sufficient conditions for chemotactic bands 显示文摘 | Keller E F Odell G M | 1975 | Math Biosci1975，27，1： | 1 |
| 8 | A New Model for Physician-Patient Communication显示文摘 | Keller V F Carroll J G | 1994 | Patient Educ Couns1994，23，2： | 1 |
| 9 | Mesoporous TiO2-based photocatalystsfor UV and visible light gas-phase toluene degradation显示文摘 | Bosc F Edwards D Keller N | 2006 | Thin Solid Films2006，495，： | 1 |
| 10 | Carbohydrate metabolism in drought-stressed leaves of pigeon pea (Cajanus)显示文摘 | Keller F Ludlow M M | 1993 | Journal ofExperimental Botany1993，44，8： | 1 |
| 11 | Conditioning aluminum alloys for electroplating显示文摘 | Keller F Zelley W G | 1950 | Journal of the Electrochemical Society1950，97，4： | 1 |
| 12 | Unlocking fungal cryptic natural products 显示文摘 | Chiang Y M Lee K H Sanchez J F Keller N P & Wang C C | 2009 | Nat Prod Commun2009，4，15： | 1 |
| 13 | Xanthophyll biosynthesis: molecular and functional characterization of carotenoid hydroxylases from pepper fruits Capsicum trmuum L显示文摘 | Bouvier F Keller Y Harlingue A | 1998 | Biochimicaet Biophysica Acta1998，1391，： | 1 |
| 14 | Gamma-irradia- tion markedly inhibits the hydrated collagen gel contra-diction by arterial smooth muscle cells 显示文摘 | Keller P F Verin V Ziegler T | 2001 | J Invest Med2001，49，3： | 1 |
| 15 | 查看详情显示文摘 | Keller U Miller D A B Boyd G D Chiu T H Ferguson J F Asom M T | | 0，，： | 1 |
| 16 | Including RNA secondary structures improves accuracy and robustness in reconstruction of phylogenetic trees显示文摘 | Keller A F?rster F Müller T | 2010 | Biol Direct2010，5，4： | 1 |
| 17 | Thermally oxidized die- tary fats increase the susceptibility of rat LDL lipid pe- roxidation but not their uptake by macrophages 显示文摘 | Eder K Keller U Hirche F | 2003 | Journal of Nutrition2003，133，： | 1 |
| 18 | Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation显示文摘 | Schlegel G Keller J Hirche F | 2012 | BMC Vet Res2012，8，1： | 1 |
| 19 | Carbohydrate metabolism in droughtstressed leaves of pigeonnpea( Cahanus cajan )显示文摘 | Keller F Ludlow M M | 1981 | Plant Physiol1981，67，1： | 1 |
| 20 | Cold Fusion in Symmetric ^90Zr-induced Reactions显示文摘 | Keller J G Schmidt K H Hessberger F P | 1986 | Nucl Phys1986，452，： | 1 |
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