|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Rhubarb extract partially improves mucosal integrity in chemotherapy-induced intestinal mucositis显示文摘AIM To investigate the effects of orally gavaged aqueous rhubarb extract(RE) on 5-fluorouracil(5-FU)-induced intestinal mucositis in rats. METHODS Female Dark Agouti rats(n = 8/group) were gavaged daily(1 mL) with water, high-dose RE(HDR; 200 mg/kg) or low-dose RE(LDR; 20mg/kg) for eight days. Intestinal mucositis was induced(day 5) with 5-FU(150 mg/kg) via intraperitoneal injection. Intestinal tissue samples were collected for myeloperoxidase(MPO) activity and histological examination. Xenopus oocytes expressing aquaporin 4 water channels were prepared to examine the effect of aqueous RE on cell volume, indicating a potential mechanism responsible for modulating net fluid absorption and secretion in the gastrointestinal tract. Statistical significance was assumed at P < 0.05 by one-way ANOVA. RESULTS B o d y w e i g h t w a s s i g n i f i c a n t l y r e d u c e d i n r a t s administered 5-FU compared to healthy controls(P < 0.01). Rats administered 5-FU significantly increased intestinal MPO levels(≥ 307%; P < 0.001), compared to healthy controls. However, LDR attenuated this effect in 5-FU treated rats, significantly decreasing ileal MPO activity(by 45%; P < 0.05), as compared to 5-FU controls. 5-FU significantly reduced intestinal mucosal thickness(by ≥ 29% P < 0.001) as compared to healthy controls. LDR significantly increased ileal mucosal thickness in 5-FU treated rats(19%; P < 0.05) relative to 5-FU controls. In xenopus oocytes expressing AQP4 water channels, RE selectively blocked water influx into the cell, induced by a decrease in external osmotic pressure. As water efflux was unaltered by the presence of extracellular RE, the directional flow of water across the epithelial barrier, in the presence of extracellular RE, indicated that RE may alleviate water loss across the epithelial barrier and promote intestinal health in chemotherapy-induced intestinal mucositis.CONCLUSION In summary, low dose RE improves selected parameters of mucosal integrity and reduces ileal inflammation, manifesting from 5-FU-induced intestinal mucositis. | Juliana E Bajic Georgina L Eden Lorrinne S Lampton Ker Y Cheah Kerry A Lymn Jinxin V Pei Andrea J Yool Gordon S Howarth | 2016 | World Journal of Gastroenterology2016，22，37： | 3 |
| 2 | Effects of growth medium,inoculum size,and incubation time on culturability and isolation of soil bacteria显示文摘 | Davis KER Joseph S J Janssen PH | | 0，，02： | 1 |
| 3 | Overexpression of transfected human ribonucleotide reductase M2 subunit in human ribonucleotide their invasive potential显示文摘 | ZHOU B S TSAI P KER R | 1998 | Clin Exp Metastasis1998，16，： | 1 |
| 4 | Hardware implemenation of CMAC neural network with reduced storage requirement 显示文摘 | KER J S KUO Y H | 1997 | IEEE Transactionso Neural Networks1997，8，6： | 1 |
| 5 | A Fuzzy CMAC Model for Color Reproducion显示文摘 | J S Ker C C Hsu Y H Kuo | 1977 | Fuzzy Sets and Systems1977，91，1： | 1 |
| 6 | High-performance SIFT hardware accelerator for real-time image feature extraction 显示文摘 | HUANG F C HUANG S Y KER J W | 2012 | IEEE Transactions on Circuits and Systems for Video Technology2012，22，3： | 1 |
| 7 | Hydrate dissolution as a potential mechanism for pockmark formation in the Niger delta显示文摘 | Sultan N Marsset B Ker S | 2010 | Journal of Geophysical Research2010，115，8： | 1 |
| 8 | Failure to induce supracrestal bonegrowth between and around partial y inserted titanium implants using bone morphogenetic protein(BMP):an experimental study in dog显示文摘 | Stenport VF Roos-Jans?ker AM Renvert S | | 0，，02： | 1 |
| 9 | Component-level measurement for transient-induced latch-up in CMOS ICs under system-level ESD considerations显示文摘 | KER Ming-dou HSU S F | 2006 | IEEE Transactions on Device and Materials Reliability2006，6，3： | 1 |
| 10 | Modeling and off- design performance of a 1 kWe HT-PEMFC (high tem- perature-proton exchange membrane fuel cell)-based residential micro-CHP (combined-heat-and-power) sys- tem for Danish single-family households显示文摘 | Arsalis A Nielsen M P Ker S K | 2011 | Energy2011，36，2： | 1 |
| 11 | A Fuzzy CMAC Model for Color Reproducion显示文摘 | J S Ker C C Hsu Y H Kuo | 1977 | Fuzzy Sets and Systems1977，91，1： | 1 |
| 12 | Identification of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a binding protein for a 68 kDa Bacillus thuringiensis parasporal protein cytotoxic against leukaemic cells显示文摘 | KRISHNAN K KER J E A MOHAMMED S M | 2010 | Journal of Biomedical Science2010，17，1： | 1 |
| 13 | Physical mechanism and device simulation on transient-induced latchup in CMOS ICs under system-level ESD test显示文摘 | KER M D HSU S F | 2005 | IEEE Transactions on Electron Devices2005，52，8： | 1 |
| 14 | Alternative solvent - free preparationmethods for felodipine surface solid dispersions 显示文摘 | KER J S KOFLER S B | 1998 | Drug De-velopment and Industrial Pharmacy1998，24，4： | 1 |
| 15 | Determination of thiamine by continuous flow chemiluminescence measurement 显示文摘 | GREKA S N CALO KER INO S A C | 1990 | Talanta1990，37，： | 1 |
| 16 | Active ESD protection design for interface circuits between separated power domains against Cross-Power-Domain ESD stresses 显示文摘 | CHEN S H KER M D HUNG H P | 2008 | IEEE Transactions on Device and Materials Reliability2008，8，3： | 1 |
| 17 | Numerical Simulation of Surface Pitting due to Contact Loading显示文摘 | Fla? ker J Fajdiga G Glodez S | 2001 | International Journal of Fatigue2001，23，7： | 1 |
| 18 | 显示文摘 | Fang J S Hsu T P Ker M L | 2007 | J Phys Chem Solids2007，07，： | 1 |
| 19 | Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation 显示文摘 | Thesleff I Ker~inen S Jernvall J | 2001 | Adv l)ent Res2001，15，1： | 1 |
| 20 | A class-besod approach to word alignment显示文摘 | Ker S J Chang J S | 1997 | Computational Linguistics1997，23，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员